Physical characteristics of the ECAT 953B/31: a new high resolution brain positron tomograph

Mazoyer, Bernard; Trébossen, R.; Deutch, R.; Casey, M.; Blohm, Klaas-Ole

doi:10.1109/42.108583

Cited by 63 publications

(17 citation statements)

References 11 publications

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“…This tomograph has 5.8mm in-plane and 5mm axial resolution. 28 In each of the patients, 31 transverse sections of the brain, spaced 3.37mm apart, were acquired simultaneously in the hippocampal plane according to a method previously described. 27 …”

Section: Pet and Mri Data Acquisitionmentioning

confidence: 99%

Insular cortex involvement in mesiotemporal lobe epilepsy: A positron emission tomography study

Bouilleret

Dupont

Spelle

et al. 2002

Annals of Neurology

103

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Somesthetic and emotional symptoms that are common in patients with mesial temporal lobe epilepsy are usually related to hippocampo-amygdalar complex involvement. Recent stereo-electroencephalographic studies have shown a relationship between such symptoms and epileptic insular discharges. To further investigate this problem, we carried out a positron emission tomography study using fluorodeoxyglucose (18F-FDG) and flumazenil (11C-FMZ) in mesial temporal lobe epilepsy patients. The aim of our study was to assess the existence of a cortical insular involvement in order to examine its clinical correlates and the relationship between the postoperative outcome and the insular involvement. Fluorodeoxyglucose and flumazenil-positron emission tomography studies were carried out in 18 patients with mesial temporal lobe epilepsy patients. A statistical parametric mapping (SPM96) was performed to analyze the data in comparison to 18 healthy volunteers. For each set of fluorodeoxyglucose and flumazenil images a group and an individual analysis were performed. In addition, a region of interest analysis was performed to validate the results. Focusing on the metabolic abnormalities, we also investigated the role of insular cortex in the symptoms experienced by the patients and the prognostic value of insular metabolic abnormalities. Highly significant hypometabolism and BZR binding decreases were detected in the insular cortex. Results were similar using the region of interest approach. Insular involvement (mainly ipsilateral to the seizure focus) was present in 60% of the patients. Emotional symptoms correlated with hypometabolism in the anterior part of the ipsilateral insular cortex, whereas somesthetic symptoms correlated with hypometabolism in the posterior part. No relationship between postoperative outcome and ipsilateral insular hypometabolism was found. Unilateral mesial temporal lobe epilepsy is associated with insular hypometabolism and benzodiazepine receptor loss. Our results also suggest that the anterior part of the insular cortex is involved in the emotional symptoms and the posterior insular cortex is involved in the somesthetic symptoms. Hypometabolism located in the insula did not influence postoperative outcome after anterior lobectomy.

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Section: Pet and Mri Data Acquisitionmentioning

confidence: 99%

Insular cortex involvement in mesiotemporal lobe epilepsy: A positron emission tomography study

Bouilleret

Dupont

Spelle

et al. 2002

Annals of Neurology

103

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“…PET scans were acquired with a Siemens/CTI 953B in three-dimensional mode (septa retracted) [29,30]. Images were reconstructed using measured attenuation and scatter correction [31] to a resolution of 4.3 mm full-width at half-maximum at the slice centers in all three dimensions.…”

Section: Petmentioning

confidence: 99%

Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans

Antenor-Dorsey

Markham

Moerlein

et al. 2008

Nuclear Medicine and Biology

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PET measurements of dopaminergic D 2 -like receptors may provide important insights into disorders such as Parkinson's disease, schizophrenia, dystonia and Tourette's syndrome. The PET radioligand [ 18 F] (N-Methyl)Benperidol ([ 18 F]-NMB) has high affinity and selectivity for D 2 -like receptors and is not displaced by endogenous dopamine. The goal of this study is to evaluate use of a graphical method utilizing a reference tissue region for ([ 18 F]-NMB PET analysis by comparisons to an explicit three-compartment tracer kinetic model and graphical method that use arterial blood measurements. We estimated binding potential (BP) in the caudate and putamen using all three methods in 16 humans and found that the three-compartment tracer kinetic method provided the highest BP estimates while the graphical method using a reference region yielded the lowest estimates (p<0.0001 by repeated measures ANOVA). However, the three methods yielded highly correlated BP estimates for the two regions of interest. We conclude that the graphical method using a reference region still provides a useful estimate of BP comparable to methods using arterial blood sampling, especially since the reference region method is less invasive and computationally more straightforward; thereby simplifying these measurements.

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“…PET images were acquired using a ECAT 953B scanner (Siemens/CTI, Knoxville, TN) in stationary 2D mode [12,13]. Single scans have 31 slices with 3.37 mm separation for an axial field of view of 10.5 cm.…”

Section: Instrumentationmentioning

confidence: 99%

Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates

Antenor-Dorsey

Laforest

Moerlein

et al. 2007

Eur J Nucl Med Mol Imaging

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Purpose-N-([ 11 C]methyl)benperidol ([ 11 C]NMB) can be used for positron emission tomography (PET) measurements of D 2 -like dopamine receptor binding in vivo. We report the absorbed radiation dosimetry of i.v.-administered 11 C-NMB, a critical step before applying this radioligand to imaging studies in humans.Materials and methods-Whole-body PET imaging with a CTI/Siemens ECAT 953B scanner was done in a male and a female baboon. After i.v. injection of 444-1221 MBq of 11 C-NMB, sequential images taken from the head to the pelvis were collected for 3 h. Volumes of interest (VOIs) were identified that entirely encompassed small organs (whole brain, striatum, eyes, and myocardium). Large organs (liver, lungs, kidneys, lower large intestine, and urinary bladder) were sampled by drawing representative regions within the organ volume. Time-activity curves for each VOI were extracted from the PET, and organ residence times were calculated by analytical integration of a multi-exponential fit of the time-activity curves. Human radiation doses were estimated using OLINDA/EXM 1.0 and the standard human model.Results-Highest retention was observed in the blood and liver, each with total residence times of 1.5 min. The highest absorbed radiation doses were to the heart (10.5 mGy/kBq) and kidney (9.19 mGy/kBq), making these the critical organs for [ 11 C]NMB. A heart absorption of 50 mGy would result from an injected dose of 4,762 MBq [ 11 C]NMB.

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Physical characteristics of the ECAT 953B/31: a new high resolution brain positron tomograph

Cited by 63 publications

References 11 publications

Insular cortex involvement in mesiotemporal lobe epilepsy: A positron emission tomography study

Insular cortex involvement in mesiotemporal lobe epilepsy: A positron emission tomography study

Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans

Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates

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