Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations

Corrente, Federica; Matricardi, Pietro; Paolicelli, Patrizia; Tita, B.; Vitali, Federica; Casadei, Maria Antonietta

doi:10.3390/molecules14082684

Cited by 19 publications

(12 citation statements)

References 21 publications

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“…, the consumer's first contact with the formulation. In addition the rheological characteristics may also be an indication of changes caused by the addition of some active substances [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

et al. 2012

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Chemically stable ester derivatives of vitamins A, C and E have become a focus of interest for their role in the satisfactory results in skin aging treatments. Accordingly, the aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl acetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer was used to determine rheological behavior of formulations containing the vitamins. Chemical stability was determined by HPLC on a Shimadzu system with UV detection. Results showed that formulations had pseudoplastic behavior and that vitamins did not alter their apparent viscosity and thixotropy. In the chemical stability studies, first-order reaction equations were used for determinations of the shelf-life of vitamins derivatives considering a remaining concentration of 85%. Combined vitamins in a single formulation had a slightly lower degradation rate as compared to different preparations containing only one of the vitamins. Considering that many cosmetic formulations contain vitamin combinations it is suggested that the present study may contribute to the development of more stable formulations containing liposoluble vitamins.

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Section: Resultsmentioning

confidence: 99%

Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

et al. 2012

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“…Primary skin irritation tests showed a good biocompatibility of the new polymer, as well as of its hydrogels. These results suggested a potential of the new hydrogels for the development of modified delivery systems in oral and topical formulations [211,212].…”

Section: Scleroglucanmentioning

confidence: 81%

Advances in Natural Polymers as Pharmaceutical Excipients

Ogaji¹,

Nep²,

Audu-Peter³

2012

Pharm Anal Acta

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Research in natural polymeric materials has witnessed growing interest and attention. This is attributable to a number of factors which include their relative abundance, low cost, and biodegrable and eco-firendly profiles. This article reviews the current applications of natural polymeric materials in pharmaceutical formulations. The pharmaceutical applications of some of the traditional and commercially available natural polymers were discussed. Emerging potential pharmaceutical excipients of natural origins were also discussed. The increasing research interests in this group of materials are indications of their increasing importance. It is believed that as technology and testing techniques advance, more understanding of their physicochemical nature would be gained that can enable them to be tailored for wider Pharmaceutical applications than their synthetic counterparts.

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“…It is very important to evaluate the physical properties during the development of a topical formulation as these parameters indicate features related to spreadability, which is primordial when considering the consumer’s first contact with the formulation and it can determine and influence their choice of product. In addition, rheological characteristics also indicate changes and instability signals caused by the addition of some active substances [21].…”

Section: Resultsmentioning

confidence: 99%

Stability of Sunscreens Containing CePO4: Proposal for a New Inorganic UV Filter

Seixas

Serra

2014

Molecules

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Inorganic UV filters have become attractive because of their role in protecting the skin from the damage caused by continuous exposure to the sun. However, their large refractive index and high photocatalytic activity have led to the development of alternative inorganic materials such as CePO 4 for application as UV filters. This compound leaves a low amount of white residue on the skin and is highly stable. The aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing ordinary organic UV filters combined with 5% CePO 4 , and, to compare it with other formulations containing the same vehicle with 5% TiO 2 or ZnO as inorganic materials. The rheological behavior and chemical stability of the formulations containing these different UV filters were investigated. Results showed that the formulation containing CePO 4 is a promising innovative UV filter due to its low interaction with organic filters, which culminates in longer shelf life when compared with traditional formulations containing ZnO or TiO 2 filters. Moreover, the recognized ability of CePO 4 to leave a low amount of white residue on the skin combined with great stability, suggests that CePO 4 can be used as inorganic filter in high concentrations, affording formulations with high SPF values.

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Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations

Cited by 19 publications

References 21 publications

Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

Advances in Natural Polymers as Pharmaceutical Excipients

Stability of Sunscreens Containing CePO4: Proposal for a New Inorganic UV Filter

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