Physical aspects of the emergence of living cell precursors: the ion and chiral asymmetries as two fundamental asymmetry types

Твердислов, В. А.; Yakovenko, L. V.

doi:10.3103/s0027134908030016

Cited by 21 publications

(9 citation statements)

References 10 publications

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“…The tendency to such equilibrium is most probably dependent on many factors, since at the constant temperature, pressure and pH of the medium, the entropy of molecules of a chirally pure system was found to be zero (S = 0), while for a racemic mixture it takes a completely different form: S = kLn2, where 'k' is the Boltzmann constant (Tverdislov and Yakovenko 2008).…”

Section: Stereoisomerism Of D-amino Acidsmentioning

confidence: 99%

D-amino acids in nature, agriculture and biomedicine

et al. 2019

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Information accumulated over the past decades on the physiological functions and metabolic pathways of biosynthesis and degradation of D-amino acids has led to a renewed interest in their study. These isomers are known to form both in nature and during the chemical synthesis of L-amino acids for feeding and pharmacological purposes, as well as in the industrial processing of some raw materials. This article discusses the positive and negative effects of D-amino acids on the human body, animals and the environment. In addition, the scientific data concerning the mechanisms of cytotoxic action of D-amino acids and their industrial and biomedical potential are summarized. ARTICLE HISTORY

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Section: Stereoisomerism Of D-amino Acidsmentioning

confidence: 99%

D-amino acids in nature, agriculture and biomedicine

et al. 2019

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“…The origin and potential role of chiral asymmetry in biology have attracted the attention of the research community throughout the years [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Although, at the macroscopic level, nonbiological structures with a homochiral molecular basis are not known, living organisms have been engaged in a unique experiment of creating stable homochiral systems.…”

Section: Introductionmentioning

confidence: 99%

Chiral Dualism as an Instrument of Hierarchical Structure Formation in Molecular Biology

Твердислов

Malyshko

2020

Symmetry

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The origin of chiral asymmetry in biology has attracted the attention of the research community throughout the years. In this paper we discuss the role of chirality and chirality sign alternation (L-D-L-D in proteins and D-L-D-L in DNA) in promoting self-organization in biology, starting at the level of single molecules and continuing to the level of supramolecular assemblies. In addition, we also discuss chiral assemblies in solutions of homochiral organic molecules. Sign-alternating chiral hierarchies created by proteins and nucleic acids are suggested to create the structural basis for the existence of selected mechanical degrees of freedom required for conformational dynamics in enzymes and macromolecular machines. Author Contributions: Conceptualization, V.A.T.; investigation, E.V.M.; writing-original draft preparation, V.A.T. and E.V.M. All authors have read and agreed to the published version of the manuscript.

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“…The Norrish type II reaction necessitates more motion of the hydrocarbon tail, allowing it to fold over on itself, a situation requiring a more dilute solute environment (less likely in the surface region). Water surfaces, such as those found on oceans, lakes, and atmospheric aerosol particles, have been implicated as unique prebiotic reaction environments previously. − Here, we add an additional example of the advantageous environment provided by the water surface for chemistry.…”

mentioning

confidence: 96%

Photoinitiated Synthesis of Self-Assembled Vesicles

et al. 2014

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The aqueous photochemistry of 2-oxooctanoic acid (a single-tailed surfactant) results in the synthesis of a double-tailed surfactant product followed by spontaneous self-assembly into vesicles. The photochemical mechanism is detailed here, and the reaction products are identified using mass spectrometry. Then, the self-assembled vesicles are characterized using dynamic light scattering, fluorescence microscopy, and NMR. Further, their stability over time and in the presence of MgCl2 salt is demonstrated. This work contributes to membrane evolution through the provision of a prebiotic route for the synthesis of plausible membrane components and subsequent self-assembly of a primitive enclosure.

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Physical aspects of the emergence of living cell precursors: the ion and chiral asymmetries as two fundamental asymmetry types

Cited by 21 publications

References 10 publications

D-amino acids in nature, agriculture and biomedicine

D-amino acids in nature, agriculture and biomedicine

Chiral Dualism as an Instrument of Hierarchical Structure Formation in Molecular Biology

Photoinitiated Synthesis of Self-Assembled Vesicles

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