Physical and thermal characterisation of Precirol® and Compritol® as lipophilic glycerides used for the preparation of controlled-release matrix pellets

Hamdani, Jamila

doi:10.1016/s0378-5173(03)00229-1

Cited by 164 publications

(99 citation statements)

References 9 publications

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“…22,36 Also the lipid nanoparticles prepared using Poloxamers have been shown to inhibit phagocytosis. 37 But, in the in vitro study, the nanoparticles prepared using Poloxamer 407 did not exhibit a steric stabilization effect. To confirm concentration dependence of the steric stabilization effect of Poloxamer, the nanoparticles were prepared using different Poloxamer 407 concentrations (2% wt/vol, 4% wt/vol, and 6% wt/vol) ( Figure 6).…”

Section: In Vitro Steric Stability By An Electrolyte-induced Flocculamentioning

confidence: 92%

Etoposide-loaded nanoparticles made from glyceride lipids: Formulation, characterization, in vitro drug release, and stability evaluation

Reddy¹,

Murthy²

2005

AAPS PharmSciTech

114

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The aim of the study was to prepare etoposide-loaded nanoparticles with glyceride lipids and then characterize and evaluate the in vitro steric stability and drug release characteristics and stability. The nanoparticles were prepared by melt emulsification and homogenization followed by spray drying of nanodispersion. Spray drying created powder nanoparticles with excellent redispersibility and a minimal increase in particle size (20-40 nm). Experimental variables, such as homogenization pressure, number of homogenization cycles, and surfactant concentration, showed a profound influence on the particle size and distribution. Spray drying of Poloxamer 407-stabilized nanodispersion lead to the formation of matrix-like structures surrounding the nanoparticles, resulting in particle growth. The in vitro steric stability test revealed that the lipid nanoparticles stabilized by sodium tauroglycocholate exhibit excellent steric stability compared with Poloxamer 407. All 3 glyceride nanoparticle formulations exhibited sustained release characteristics, and the release pattern followed the Higuchi equation. The spray-dried lipid nanoparticles stored in black polypropylene containers exhibited excellent long-term stability at 25°C and room light conditions. Such stable lipid nanoparticles with in vitro steric stability can be a beneficial delivery system for intravenous administration as long circulating carriers for controlled and targeted drug delivery.

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Section: In Vitro Steric Stability By An Electrolyte-induced Flocculamentioning

confidence: 92%

Etoposide-loaded nanoparticles made from glyceride lipids: Formulation, characterization, in vitro drug release, and stability evaluation

Reddy¹,

Murthy²

2005

AAPS PharmSciTech

114

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“…Wide arrays of wax-lipid based hydrophobic materials are available for sustaining drug action as Compritol® 888 ATO (glyceryl behenate) [19][20][21], Precirol® ATO 5 (glyceryl palmito-stearate) [22][23][24], stearic acid [23][24][25], and tristearin [26].…”

Section: Introductionmentioning

confidence: 99%

Formulation and In Vitro and In Vivo Evaluation of Lipid-Based Terbutaline Sulphate Bi-layer Tablets for Once-Daily Administration

et al. 2015

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Abstract. The objective of this study was to prepare and evaluate terbutaline sulphate (TBS) bi-layer tablets for once-daily administration. The bi-layer tablets consisted of an immediate-release layer and a sustained-release layer containing 5 and 10 mg TBS, respectively. The sustained-release layer was developed by using Compritol®888 ATO, Precirol® ATO 5, stearic acid, and tristearin, separately, as slowly eroding lipid matrices. A full 4×2 2 factorial design was employed for optimization of the sustainedrelease layer and to explore the effect of lipid type (X 1 ), drug-lipid ratio (X 2 ), and filler type (X 3 ) on the percentage drug released at 8, 12, and 24 h (Y 1 , Y 2 , and Y 3 ) as dependent variables. Sixteen TBS sustained-release matrices (F1-F16) were prepared by melt solid dispersion method. None of the prepared matrices achieved the targeted release profile. However, F2 that showed a relatively promising drug release was subjected to trial and error optimization for the filler composition to develop two optimized matrices (F17 and F18). F18 which consisted of drug-Compritol®888 ATO at ratio (1:6 w/w) and Avicel PH 101/dibasic calcium phosphate mixture of 2:1 (w/w) was selected as sustained-release layer. TBS bilayer tablets were evaluated for their physical properties, in vitro drug release, effect of storage on drug content, and in vivo performance in rabbits. The bi-layer tablets showed acceptable physical properties and release characteristics. In vivo absorption in rabbits revealed initial high TBS plasma levels followed by sustained levels over 24 h compared to immediate-release tablets.

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“…Physical ageing effects associated with glyceride-based dosage forms have to be well understood in order to avoid any further drug release alteration during storage (20). Release stability profiles of the selected micro-pellet formula (PB) were performed over a one-year study period, under shelf storage conditions (room temperature 25 °C and 25 % relative humidity).…”

Section: Preparation Of Qt Slmpmentioning

confidence: 99%

A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets

et al. 2016

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Physical and thermal characterisation of Precirol® and Compritol® as lipophilic glycerides used for the preparation of controlled-release matrix pellets

Cited by 164 publications

References 9 publications

Etoposide-loaded nanoparticles made from glyceride lipids: Formulation, characterization, in vitro drug release, and stability evaluation

Etoposide-loaded nanoparticles made from glyceride lipids: Formulation, characterization, in vitro drug release, and stability evaluation

Formulation and In Vitro and In Vivo Evaluation of Lipid-Based Terbutaline Sulphate Bi-layer Tablets for Once-Daily Administration

A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets

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