Physical and social anhedonia are associated with suicidality in major depression, but not in schizophrenia

Šagud, Marina; Tudor, Lucija; Šimunić, Lucija; Jezernik, Dejana; Madžarac, Zoran; Jakšić, Nenad; Peleš, Alma Mihaljević; Vuksan-Ćusa, Bjanka; Filipčić, Ivona Šimunović; Stefanović, Ivana; Mikulic, Suzan Kudlek; Pivac, Nela

doi:10.1111/sltb.12724

Cited by 23 publications

(11 citation statements)

References 50 publications

(55 reference statements)

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“…Sagud et al [ 19 ] explored the association of physical and social anhedonia with recent suicidal ideation in three groups of subjects: non-psychiatric controls (N = 193), schizophrenia (N = 312) and major depressive disorder (N = 178). Recent suicidal ideation was rated using item 10 of the MADRS and physical and social anhedonia using the Chapman revised social and anhedonia scales.…”

Section: Discussionmentioning

confidence: 99%

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Relationships between Recent Suicidal Ideation and Recent, State, Trait and Musical Anhedonias in Depression

Hein

Dekeuleneer

Hennebert

et al. 2022

IJERPH

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The aim of the study was to explore in depression the relationship between recent suicidal ideation and the different anhedonias taking into account the severity of depression. Recent studies have suggested that recent change of anhedonia and not state or trait anhedonia is associated with recent suicidal ideations even when the level of depression is controlled. Three samples were used (74 severe major depressives, 43 outpatients with somatic disorders presenting mild or moderate depression and 36 mild or moderate depressives hospitalized in the intensive coronary unit). Recent change of anhedonia was rated by the anhedonia subscale of the Beck Depression Inventory (BDI-II), state anhedonia by the Snaith–Hamilton Pleasure Scale (SHAPS), trait anhedonia by the TEPS (Temporal Experience of Pleasure Scale), musical anhedonia by the BMRQ (Barcelona Music Reward Questionnaire), social recent change of anhedonia by the SLIPS (Specific Loss of Interest and Pleasure Scale), the severity of depression by the BDI-II and the distinction between melancholic and non-melancholic was found using a subscale of the BDI-II. Bivariate and multivariate regression analyses were performed in each sample. In severe major depressives and, notably, in melancholia, recent suicidal ideation was associated with trait anhedonia; however, in mild or moderate depression, recent suicidal ideation was associated with recent change of anhedonia. Musical anhedonia and social recent change of anhedonia were not associated with recent suicidal ideation. Trait anhedonia could be, in severe depression, a strong predictor of recent suicidal ideation.

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Section: Discussionmentioning

confidence: 99%

“…In mood disorders, including subjects with anxiety, depressive or bipolar disorders, six studies have reported contradictory results concerning the relationships between suicidal ideation and recent change, state or trait anhedonia [ 10 , 11 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Relationships between Recent Suicidal Ideation and Recent, State, Trait and Musical Anhedonias in Depression

Hein

Dekeuleneer

Hennebert

et al. 2022

IJERPH

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“…In humans, social anhedonia is found in many diagnoses including schizophrenia and MDD and can result in lack of social support (Weeks et al, 1980 ; Llerena et al, 2012 ; Eglit et al, 2018 ). With social support being identified as a predictor of good prognosis and quality of life, blunted social functioning proves to be a major obstacle for those with mental health diagnoses (Chevallier et al, 2012 ; Eglit et al, 2018 ; Sagud et al, 2021 ).…”

Section: Early Adversity Social Behavior and Psychopathologymentioning

confidence: 99%

“…Chronic DA suppression from an overactive habenula may contribute to anhedonia and persistent feelings of an aversive state, a potential contributor to MDD (Dichter, 2010 ; American Psychiatric Association, 2013 ; Proulx et al, 2014 ). Recent work links general anhedonia with increased suicidal ideation, and social anhedonia with increased suicide attempts (Sagud et al, 2021 ). Furthermore, recent work has shown increased habenular activity in response to feedback in those with MDD in addition to blunted reward prediction error and increased punishment prediction error correlating with depressive episodes, implicating perturbed reward learning in MDD (Liu et al, 2017 ; Kumar et al, 2018 ).…”

Section: Early Adversity Social Behavior and Psychopathologymentioning

confidence: 99%

Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications

Packard

Opendak

2022

Front. Behav. Neurosci.

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Flexible and context-appropriate social functioning is key for survival across species. This flexibility also renders social behavior highly plastic, particularly during early development when attachment to caregiver can provide a template for future social processing. As a result, early caregiving adversity can have unique and lasting impacts on social behavior and even confer vulnerability to psychiatric disorders. However, the neural circuit mechanisms translating experience to outcome remain poorly understood. Here, we consider social behavior scaffolding through the lens of reward and threat processing. We begin by surveying several complementary rodent models of early adversity, which together have highlighted impacts on neural circuits processing social cues. We next explore these circuits underlying perturbed social functioning with focus on dopamine (DA) and its role in regions implicated in social and threat processing such as the prefrontal cortex (PFC), basolateral amygdala (BLA) and the lateral habenula (LHb). Finally, we turn to human populations once more to examine how altered DA signaling and LHb dysfunction may play a role in social anhedonia, a common feature in diagnoses such as schizophrenia and major depressive disorder (MDD). We argue that this translational focus is critical for identifying specific features of adversity that confer heightened vulnerability for clinical outcomes involving social cue processing.

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“…Anhedonia refers to a reduced ability or capacity to feel pleasure from otherwise pleasurable experiences [10]. Anhedonia may develop across different mental disorders but is more commonly observed in individuals with major depression and schizophrenia than in healthy individuals [11]. The two sub-types are physical anhedonia, an inability to experience physical pleasure, and social anhedonia, a reduced capacity to feel pleasure in social situations [12].…”

Section: Introductionmentioning

confidence: 99%

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia

Madžarac

Tudor

Šagud

et al. 2021

CIMB

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Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. The study determined the association between COMT rs4680 and rs4818, MAO-B rs1799836 and rs6651806 polymorphisms, the severity of negative symptoms, and physical and social anhedonia in schizophrenia. Sex-dependent associations were detected in a research sample of 302 patients with schizophrenia. In female patients with schizophrenia, the presence of the G allele or GG genotype of COMT rs4680 and rs4818, as well as GG haplotype rs4818-rs4680, which were all related to higher COMT activity, was associated with an increase in several dimensions of negative symptoms and anhedonia. In male patients with schizophrenia, carriers of the MAO-B rs1799836 A allele, presumably associated with higher MAO-B activity, had a higher severity of alogia, while carriers of the A allele of the MAO-B rs6651806 had a higher severity of negative symptoms. These findings suggest that higher dopamine degradation, associated with COMT and MAO-B genetic variants, is associated with a sex-specific increase in the severity of negative symptoms in schizophrenia patients.

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Physical and social anhedonia are associated with suicidality in major depression, but not in schizophrenia

Cited by 23 publications

References 50 publications

Relationships between Recent Suicidal Ideation and Recent, State, Trait and Musical Anhedonias in Depression

Relationships between Recent Suicidal Ideation and Recent, State, Trait and Musical Anhedonias in Depression

Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia

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