Physical and Psychosocial Contributors to Quality of Life in Veterans With Hepatitis C Not on Antiviral Therapy

Rowan, Paul; Al-Jurdi, Rayan; Tavakoli–Tabasi, Shahriar; Kunik, Mark E.; Satrom, Sarah L; El–Serag, Hashem B.

doi:10.1097/01.mcg.0000173860.08478.a6

Cited by 50 publications

(44 citation statements)

References 19 publications

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“…This result is difficult to explain because having a current disorder could be associated with greater loss in all dimensions, since psychiatric symptoms can worsen HRQOL, as reported in other studies [14,20].…”

Section: Discussionmentioning

confidence: 50%

“…Patients with CHC that presented more advanced fibrosis (stage 3 and 4) did not differ in their SF-36 scores, except in the dimension of mental health, in comparison to those who presented less advanced fibrosis (stage 1 and 2). Most studies have not demonstrated an association between stage of fibrosis and quality of life, except in cases of advanced cirrhosis [3,8,9,14,20,28,29]. In our study, only 54.5% were submitted to a biopsy and only four of them (8.2%) had cirrhosis.…”

Section: Discussionmentioning

confidence: 60%

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Impact of psychiatric disorders on the quality of life of brazilian HCV-infected patients

Batista-Neves¹,

Almeida²,

Cardeal³

et al. 2009

Braz J Infect Dis

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The aim of our study was to determine the impact of psychiatric comorbidities on the health-related quality of life of HCV-infected patients. Assessment of clinical, socio-demographic and quality of life data of the patients followed up at a Hepatology unit was performed by using a standard questionnaire and the SF-36 instrument. Psychiatric diagnoses were confirmed by using the Mini International Neuropsychiatric Interview, Brazilian version 5.0.0 (MINI Plus). Evaluation using the MINI plus demonstrated that 46 (51%) patients did not have any psychiatric diagnosis, while 44 (49%) had at least one psychiatric diagnosis. Among patients with a psychiatric comorbidity, 26 (59.1%) had a current mental disorder, out of which 22 (84.6%) had not been previously diagnosed. Patients with psychiatric disorders had lower scores in all dimensions of the SF-36 when compared to those who had no psychiatric diagnosis. Scores of physical functioning and bodily pain domains were lower for those suffering from a current psychiatric disorder when compared to those who had had a psychiatric disorder in the past. Females had lower scores of bodily pain and mental health dimensions when compared to males. Scores for mental health dimension were also lower for patients with advanced fibrosis. The presence of a psychiatric comorbidity was the variable that was most associated with the different scores in the SF-36, compared to other variables such as age, gender, aminotransferase levels, and degree of fibrosis.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 60%

Impact of psychiatric disorders on the quality of life of brazilian HCV-infected patients

Batista-Neves¹,

Almeida²,

Cardeal³

et al. 2009

Braz J Infect Dis

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“…They found that higher body mass index, cirrhosis, female gender, and presence of anemia were associated with reduced HRQOL, but when depression was entered into the analysis, the other effects were no longer significant and depression was a strong, solitary predictor of lower SF-36 scores during treatment. Rowan et al [33] looked at variables predicting scores on the SF-36 and Chronic Liver Disease Questionnaire administered to US veterans and found that demographic, clinical, and viral indicators were not significant predictors whereas anxiety and depression scores were. Like other studies, higher depression scores were the strongest predictor of lower HRQOL on both measures.…”

Section: Resultsmentioning

confidence: 97%

Health-related quality of life in HCV-infected patients

Groessl

Weingart²,

Kaplan³

et al. 2007

Curr hepatitis rep

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In March 2007, a systematic review was conducted of published research on the topic of health-related quality of life (HRQOL) in patients with hepatitis C virus (HCV) infection. Recent studies indicate that significant decrements in HRQOL exist for patients with HCV under many circumstances and arise from multiple sources. Future research is needed on finding interventions that address all sources of reduced HRQOL in patients with HCV, whether or not they are on treatment. It is also important to continue work on identifying the direct mechanisms behind lower HRQOL in patients with HCV.

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“…33 In addition to depression, CHC has been shown to be associated with other psychiatric comorbidities that may themselves contribute to a poorer HRQOL. 4,16,34 Despite the results of multivariate analyses in this study, the influence of anxiety disorder influence on the HRQOL of patients with CHC should not be ignored. The prevalence of anxiety disorders in patients with CHC has been shown to be as high as that of clinical depression.…”

Section: Discussionmentioning

confidence: 99%

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Silva

Cunha

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: Patients with chronic hepatitis C (CHC) have a poorer quality of life than those with other chronic liver diseases. However, some of the factors that determine health-related quality of life (HRQOL) in these patients, such as the degree of liver fibrosis, are still controversial. Therefore, the aim of the present study was to investigate the impact of CHC on HRQOL by conducting clinical, psychiatric, and sociodemographic evaluations. Methods: One hundred and twenty-four consecutive patients attending a referral center for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview, the Hamilton Depression Rating Scale, the Hospital Anxiety and Depression Scale, and the Medical Outcomes Study 36-Item Short-Form Health Survey. Multiple linear regression analyses were used to quantify independent associations between HRQOL and the clinical, psychiatric, and sociodemographic variables of interest. Results: Reduced HRQOL was independently associated with major depressive disorder (MDD) and with elevated levels of alanine aminotransferase, but was not associated with hepatic cirrhosis. Conclusions: MDD rather than the grade of liver fibrosis was strongly associated with HRQOL impairment in patients with CHC. These findings highlight that, in patients with CHC, the psychological effects of the disease deserve more attention and the implementation of integrated medical, psychiatric, and psychological care may be helpful.

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Physical and Psychosocial Contributors to Quality of Life in Veterans With Hepatitis C Not on Antiviral Therapy

Abstract: Psychosocial factors, especially depression, are strong indicators of impaired HRQOL for HCV-infected veterans not receiving antiviral therapy. Screening and treatment of psychosocial factors is recommended.

Cited by 50 publications

References 19 publications

Impact of psychiatric disorders on the quality of life of brazilian HCV-infected patients

Impact of psychiatric disorders on the quality of life of brazilian HCV-infected patients

Health-related quality of life in HCV-infected patients

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

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