Physical and Linkage Mapping of Human Chromosome 17 Loci to Dog Chromosomes 9 and 5

Werner, Petra; Raducha, Michael; Prociuk, Ulana; Henthorn, Paula S.; Patterson, Donald F.

doi:10.1006/geno.1997.4723

Cited by 58 publications

(56 citation statements)

References 50 publications

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“…These results have important implications for the design of dog genetic studies. Although early efforts focused on cross-breeding of dogs for linkage analysis [101][102][103] , it is now clear that within-breed association studies offer specific advantages in the study of both monogenic and polygenic diseases. First, they use existing dogs coming to medical attention and do not require the sampling of families with large numbers of affected individuals.…”

Section: Genesmentioning

confidence: 99%

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Lindblad‐Toh¹,

Wade²,

Mikkelsen³

et al. 2005

Nature

2,216

2,079

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Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

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Section: Genesmentioning

confidence: 99%

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Lindblad‐Toh¹,

Wade²,

Mikkelsen³

et al. 2005

Nature

2,216

2,079

View full text Add to dashboard Cite

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“…Two-point linkage was detected initially between the RCND locus and ZuBeCa6, a microsatellite marker that has been localized previously to CFA5q12-q13 (36), at a recombination fraction ( ) of 0.161, supported by a logarithm of odds (lod) score of 4.6. Several other polymorphic markers known to be on CFA5 (23,37,38) were then genotyped on the same set of pedigrees. Two-point analyses showed the disease locus to be linked to five additional markers on CFA5 with odds of at least 1,000:1 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…This rare syndrome is usually characterized by skin tumors, but few families have been described recently that also have different malignancies (50). Canine KRT9 has been cloned (51) and mapped to CFA9 (22) (22,38), and PKD1, which is involved in 85% of autosomal dominant polycystic kidney disease in humans, has been mapped to CFA6 (33). These can therefore be excluded from further consideration as candidates.…”

Section: Discussionmentioning

confidence: 99%

Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs

Jonasdottir

Mellersh

Moe

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

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“…For the construction of a complete linkage map of all candidate chromosomes approximately 300-400 polymorphic markers will be needed in order to use it for genetic studies (59). The first report of a partial linkage map in the dog was published by Werner et al (91). They showed the comparative mapping of human chromosome 17 and mouse chromosome 11 loci to canine chromosome 9.…”

Section: Modern Genetic Analysis For Locomotion Disordersmentioning

confidence: 99%

Bone disorders in the dog: A review of modern genetic strategies to find the underlying causes

Everts

Hazewinkel

Rothuizen

et al. 2000

Veterinary Quarterly

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SUMMARYIn man, the genetic defects of more than 600 inherited diseases, of which at least 150 skeletal diseases, have been identified as is the chromosomal location for approximately 7000 genes. This rapid progress has been made possible by the generation of a genetical and physical map of the human genome. There is no reason to believe that for the dog not a similar development may occur. This review is therefore focussed on the use of novel tools now available for comparative molecular genetic studies of skeletal dysplasias in the dog. Because the genomes of mammals at the subchromosomal level are very well conserved, likely candidate disease genes known from other species might be considered. In this review, formation of the bones and the most important canine disorders of the skeleton influencing locomotion will be discussed first. The canine disorders discussed are canine hip dysplasia, the three different forms of elbow dysplasia (fragmented coronoid process, ununited anconeal process, osteochondrosis dissecans and incongruency) and dwarfism. Where possible a link is made with similar diseases in man or mouse. Then, the molecular biological tools available to analyse the genetic defect will be reviewed and some examples discussed.

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Physical and Linkage Mapping of Human Chromosome 17 Loci to Dog Chromosomes 9 and 5

Cited by 58 publications

References 50 publications

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs

Bone disorders in the dog: A review of modern genetic strategies to find the underlying causes

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