Physical and histomorphological characteristics of iliac crest bone differ according to the grade of osteoarthritis at the hand

Gevers, G; Dequeker, Jan; Geusens, Piet; Behets, Catherine; Dhem, Antoine

doi:10.1016/8756-3282(89)90050-1

Cited by 79 publications

(43 citation statements)

References 20 publications

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“…The same result was found when comparing patients with OA to normal subjects [10,11]. This finding may be justified by the presence of different pathogenic factors that affect bone mass, confirming the already reported inverse association between the risk of OA and that of OP [12].…”

Section: Introductionsupporting

confidence: 86%

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Study of Peripheral Bone Mineral Density in Patients with Diffuse Idiopathic Skeletal Hyperostosis

Franco

Mauceri

Scavalli

et al. 2000

Clinical Rheumatology

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Diffuse idiopathic skeletal hyperostosis (DISH) is an ossifying systemic enthesopathy which involves not only the spine but which may also appear in other sites. Degenerative, inflammatory and metabolic factors have been reported for a possible pathogenic role in the new bone growth that characterises DISH. In the present study peripheral bone mineral density (BMD) has been measured in patients affected by DISH and the results compared to those of a control group. Forty-two patients (33 females and 9 males) affected by DISH and 84 controls (66 females and 18 males) were examined. All subjects underwent radiological study of the lumbar and dorsal spine and the pelvis. BMD was evaluated using dual-energy X-ray absorptiometry and the examination was performed in the distal radius. In DISH patients the mean value of BMD was significantly higher than in controls (P50.002), even when it was referred to sex subgroups. Statistical analysis showed significant differences between both the two male groups (P50.002) and the two female groups (P50.01). In the two female subgroups (DISH patients and controls) BMD was significantly inversely related to age and to the duration of the postmenopausal period. The present study showed higher BMD in DISH patients than in the control group.

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Section: Introductionsupporting

confidence: 86%

“…In recent reports [11] densitometric physical and histomorphometric analysis of bone samples taken from iliac crest in patients affected by OA showed high BMD. The findings showed the global skeletal involvement in OA, being the changes present not only at the affected joints but also in other articular areas.…”

Section: Discussionmentioning

confidence: 98%

Study of Peripheral Bone Mineral Density in Patients with Diffuse Idiopathic Skeletal Hyperostosis

Franco

Mauceri

Scavalli

et al. 2000

Clinical Rheumatology

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“…Hence, the apparent increase in bone density in OA may be because of an increase in material density, and not mineral density [31][32][33]. Indications of altered mineralisation and abnormal metabolic subchondral bone can be inferred from the increased osteoid matrix in this OA bone tissue [24,32,34,35]. As the osteoid matrix is primarily composed of an abundant collagen type I matrix, it was therefore of no surprise that this collagen type in the trabecular bone of the femoral heads of OA patients was found to be increased [31,32], along with abnormal collagen type I fibres, as evidenced by an increased ratio of α1 to α2 chains in OA compared to normal trabecular subchondral bone [33].…”

Section: Correlation Between In Vivo Findings In Animals and Human Oamentioning

confidence: 99%

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

Tat

Lajeunesse

Pelletier

et al. 2010

Best Practice & Research Clinical Rheumatology

153

121

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Over the past few decades, significant progress has been made with respect to new concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the knowledge we have today on the involvement of the subchondral bone in OA. It provides substantial evidence that changes in the metabolism of the subchondral bone are an integral part of the OA disease process and that these alterations are not merely secondary manifestations, but are part of a more active component of the disease. Thus, a strong rationale exists for therapeutic approaches that target subchondral bone resorption and/or formation, and data evaluating the drugs targeting bone remodelling raise the hope that new treatment options for OA may become available.

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“…More than 30 years ago, Radin et al (10,11) suggested that changes in bone might be a cause of OA. Since that time, there has been substantial evidence that changes in the metabolism of bone, particularly in the area of the subchondral bone, are an integral part of the disease (12)(13)(14)(15)(16)(17)(18). Recent studies, however, point to the fact that the fate of articular cartilage is not determined exclusively by stiffening (sclerosis) of subchondral bone, but rather, by a remodeling of this tissue (19,20).…”

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confidence: 99%

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts

Tat¹,

Pelletier²,

Amiable³

et al. 2008

Arthritis & Rheumatism

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Objective. Abnormal subchondral bone metabolism is involved in osteoarthritis (OA). It has been suggested that ephrin B2 and its specific receptor EphB4 participate in bone homeostasis. We previously reported that human OA subchondral bone osteoblasts could be classified into 2 subpopulations: low (L), having proresorption properties, and high (H), having proformation properties. The purpose of this study was to investigate the importance of the ephrin system in OA subchondral bone osteoblasts.Methods. The presence of the EphB4 receptor was determined by immunohistochemistry, and its expression level, modulation upon treatment, and consequences of activation by ephrin B2 were determined by quantitative polymerase chain reaction. The effects of ephrin B2 activation of the EphB4 receptor on bone resorption activity were also determined. EphB4 receptor activation signaling pathways were investigated by specific enzyme-linked immunosorbent assay.Results. EphB4 receptors were present in subchondral bone osteoblasts and osteocytes. Compared with normal and H-OA osteoblasts, EphB4 receptor expression levels were significantly increased in L-OA osteoblasts, with no difference between normal and H-OA osteoblasts. EphB4 receptor levels in L-OA osteoblasts were significantly up-regulated by prostaglandin E 2 (PGE 2 ) and interleukin-17 (IL-17). Ephrin B2, PGE 2 , and IL-17 significantly inhibited bone resorption activity in these cells. EphB4 activation by ephrin B2 significantly inhibited the expression of IL-1␤, IL-6, matrix metalloproteinase 1 (MMP-1), MMP-9, MMP-13, and RANKL, but not MMP-2 and osteoprotegerin. EphB4 receptor activation significantly inhibited the phosphatidylinositol 3-kinase/Akt pathway.Conclusion. This study is the first to provide evidence that EphB4 receptor activation by ephrin B2 in OA subchondral bone could affect abnormal metabolism in this tissue by inhibiting resorption factors and their activities. Ephrin B2 could be targeted as a specific therapeutic approach in the development of a diseasemodifying OA drug.Subchondral bone is made up of a specialized connective tissue formed by a mineralized matrix containing the specific type I collagen, proteoglycans, and several growth factors and cytokines, as well as bonespecific cell types (osteoblasts, osteocytes, and osteoclasts) (1,2). Osteoblast and osteoclast activities, either alone or in combination, contribute to the bone remodeling process, and any disturbance in the activities of these 2 cells is responsible for the development of altered bone metabolism.The ephrin B molecules (ephrin B1, ephrin B2, and ephrin B3) bind in a specific manner to their EphB

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Physical and histomorphological characteristics of iliac crest bone differ according to the grade of osteoarthritis at the hand

Cited by 79 publications

References 20 publications

Study of Peripheral Bone Mineral Density in Patients with Diffuse Idiopathic Skeletal Hyperostosis

Study of Peripheral Bone Mineral Density in Patients with Diffuse Idiopathic Skeletal Hyperostosis

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts

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