“…However, the observation that the truncated kidney cdb3 binds adducin was surprising in view of the fact that kidney cdb3 displays no known affinity for any other protein with which erythrocyte cdb3 normally interacts, including ankyrin, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase, aldolase, phosphofructokinase, and deoxyhemoglobin [28, 39, 46, 47]. Although the interactions of kidney band 3 have received limited study, established protein ligands of kidney cdb3 include integrin-linked kinase, nephrin, and the β1 subunit of the Na,K-ATPase [60–62]. While we were not able to find any literature demonstrating a direct band 3-adducin interaction in the kidney, several studies suggest that mutations in adducin can lead to alterations in levels of nephrin, Na,K-ATPase activity, renal sodium retention, and blood pressure [20–22, 63–65].…”