Physical and cDNA Mapping in the &lt;i&gt;DBH&lt;/i&gt; Region of Human Chromosome 9q34

Gilbert, John R.; Kumar, Arun; Newey, Sarah E.; Rao, Nagesh; Ioannou, Panos; Qiu, Hui; Lin, Dezhou; Xu, Pu; Pettenati, Mark J.; Pericak‐Vance, M. A.

doi:10.1159/000022905

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Genetic marker order and map distances were taken from Généthon (Dib et al 1996) and other published maps (Murrell et al 1995;Gilbert et al 2000). These were confirmed by running sib_map, part of the ASPEX package.…”

Section: Genetic Markersmentioning

confidence: 99%

A Genomewide Screen for Autism: Strong Evidence for Linkage to Chromosomes 2q, 7q, and 16p

Le¹,

Kelly²,

Berney³

et al. 2001

The American Journal of Human Genetics

411

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Autism is characterized by impairments in reciprocal communication and social interaction and by repetitive and stereotyped patterns of activities and interests. Evidence for a strong underlying genetic predisposition comes from twin and family studies, although susceptibility genes have not yet been identified. A whole-genome screen for linkage, using 83 sib pairs with autism, has been completed, and 119 markers have been genotyped in 13 candidate regions in a further 69 sib pairs. The addition of new families and markers provides further support for previous reports of linkages on chromosomes 7q and 16p. Two new regions of linkage have also been identified on chromosomes 2q and 17q. The most significant finding was a multipoint maximum LOD score (MLS) of 3.74 at marker D2S2188 on chromosome 2; this MLS increased to 4.80 when only sib pairs fulfilling strict diagnostic criteria were included. The susceptibility region on chromosome 7 was the next most significant, generating a multipoint MLS of 3.20 at marker D7S477. Chromosome 16 generated a multipoint MLS of 2.93 at D16S3102, whereas chromosome 17 generated a multipoint MLS of 2.34 at HTTINT2. With the addition of new families, there was no increased allele sharing at a number of other loci originally showing some evidence of linkage. These results support the continuing collection of multiplex sib-pair families to identify autism-susceptibility genes.

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Section: Genetic Markersmentioning

confidence: 99%

A Genomewide Screen for Autism: Strong Evidence for Linkage to Chromosomes 2q, 7q, and 16p

Le¹,

Kelly²,

Berney³

et al. 2001

The American Journal of Human Genetics

411

View full text Add to dashboard Cite

show abstract

“…NR_102735; UCSC ID uc031tfk.1) in HepG2 cells. DBH-AS1 is a ~2kb lncRNA with a polyadenylated tail transcribed from chromosome 9q34 [ 15 ]. Quercetin, the prototype of a naturally-occurring chemopreventive agent for various cancers, has been reported to possess anti-proliferative and antioxidant activities in hepatocytes [ 16 - 18 ].…”

Section: Introductionmentioning

confidence: 99%

HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma

et al. 2015

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Accumulating evidence supports an important role for the hepatitis B virus x protein (HBx) in the pathogenesis of hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC), but the underlying mechanisms are not entirely clear. Here, we identified a novel long noncoding RNA (lncRNA) DBH-AS1 involved in the HBx-mediated hepatocarcinogenesis. The levels of DBH-AS1 were positively correlated with hepatitis B surface antigen (HBsAg) and tumor size in HCC tissues. Functionally, transgenic expression of DBH-AS1 significantly enhanced cell proliferation and tumorigenesis, whereas short hairpin RNA knockdown of DBH-AS1 caused an inhibition of cell proliferation. Mechanistically, overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. We also found that enhanced DBH-AS1 expression inhibited serum starvation-induced apoptosis of HCC cells. In contrast, suppressed DBH-AS1 expression had opposite effects. Furthermore, DBH-AS1 was shown to activate MAPK pathway. We also provide evidence that DBH-AS1 could be significantly induced by HBx protein and markedly down-regulated by p53. Thus, we concluded that DBH-AS1 can be induced by HBx and inactivated by p53, and consequently promote cell proliferation and cell survival through activation of MAPK signaling in HCC. Our study suggests that DBH-AS1 acts as an oncogene for HCC.

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“…Dopamine β hydroxylase antisense RNA 1(DBH-AS1) is a ~2kb lncRNA transcribed from chromosome 9q34, with a polyadenylated tail transcribed from chromosome 9q34 [ 55 ]. Dendritic cells (DCs) are antigen-presenting cells, and the abnormal function of these cells causes immune-related diseases.…”

Section: Discussionmentioning

confidence: 99%

Are Antisense Long Non-Coding RNA Related to COVID-19?

et al. 2022

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Fighting external pathogens relies on the tight regulation of the gene expression of the immune system. Ferroptosis, which is a distinct form of programmed cell death driven by iron, is involved in the enhancement of follicular helper T cell function during infection. The regulation of RNA is a key step in final gene expression. The present study aimed to identify the expression level of antisense lncRNAs (A2M-AS1, DBH-AS1, FLVCR1-DT, and NCBP2AS2-1) and FLVCR1 in COVID-19 patients and its relation to the severity of the disease. COVID-19 patients as well as age and gender-matched healthy controls were enrolled in this study. The expression level of the antisense lncRNAs was measured by RT-PCR. Results revealed the decreased expression of A2M-AS1 and FLVCR1 in COVID-19 patients. Additionally, they showed the increased expression of DBH-AS1, FLVCR1-DT, and NCBP2AS2. Both FLVCR1-DT and NCBP2AS2 showed a positive correlation with interleukin-6 (IL-6). DBH-AS1 and FLVCR1-DT had a significant association with mortality, complications, and mechanical ventilation. A significant negative correlation was found between A2M-AS1 and NCBP2AS2-1 and between FLVCR1 and FLVCR1-DT. The study confirmed that the expression level of the antisense lncRNAs was deregulated in COVID-19 patients and correlated with the severity of COVID-19, and that it may have possible roles in the pathogenesis of this disease.

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Physical and cDNA Mapping in the <i>DBH</i> Region of Human Chromosome 9q34

Cited by 6 publications

References 5 publications

A Genomewide Screen for Autism: Strong Evidence for Linkage to Chromosomes 2q, 7q, and 16p

A Genomewide Screen for Autism: Strong Evidence for Linkage to Chromosomes 2q, 7q, and 16p

HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma

Are Antisense Long Non-Coding RNA Related to COVID-19?

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