Nickel catalysts prepared on high‐surface‐area mesoporous MgSiO3 were synthesized and applied in methanation of CO2. N2 adsorption analysis confirmed the presence of the mesoporous structure on the synthesized samples and revealed that the increase in nickel content resulted in a shift of the pore size distributions to smaller pore sizes. Temperature‐programmed reduction analysis illustrated an improvement in reducibility of the catalysts by a higher nickel content. Catalytic results indicated enhanced CO2 conversion with the increase in nickel percentage up to 15 wt %. The catalysts with higher percentage of nickel provided lower CO2 conversion and CH4 selectivity. The %15Ni/MgSiO3 catalyst exhibited high catalytic stability under optimized conditions.