Physical activity, sedentary behavior, and the risk of type 2 diabetes: A two-sample Mendelian Randomization analysis in the European population

Abstract

Physical activity (PA) and sedentary behaviors (SB) have been linked to the risk of type 2 diabetes (T2DM) in observational studies; however, it is unclear whether these associations are causative or confounded. This study intends to use summary genetic data from the UK Biobank and other consortiums in conjunction with the two-sample Mendelian Randomization (MR) approach to solve this problem. The inverse variance weighted (IVW) technique was utilized as the primary analysis, with sensitivity analyses using the MR-Egger, weighted-median, and MR-Pleiotropy RESidual Sum and Outlier (PRESSO) techniques. Inverse associations between self-reported moderate PA (OR: 0.3096, 95% CI: 0.1782-0.5380) and vigorous PA (OR: 0.2747, 95% CI: 0.1390-0.5428) with T2DM risk were found, respectively. However, accelerometer-based PA measurement (average acceleration) was not associated with T2DM risk (OR: 1.0284, 95% CI: 0.9831-1.0758). The time (hours/day) spent watching TV was associated with T2DM risk (OR: 2.3490, 95% CI: 1.9084-2.8915), while the time (hours/day) spent using the computer (OR: 0.8496, 95% CI: 0.7178-1.0056), and driving (OR: 3.0679, 95% CI: 0.8448-11.1415) were not associated with T2DM risk. The sensitivity analysis revealed relationships of a similar magnitude. Our study revealed that more PA and less TV viewing were related to a decreased T2DM risk, and provided genetic support for a causal relationship between PA, TV viewing, and T2DM risk.

Association between Different Domains of Sedentary Behavior and Health-Related Quality of Life in Adults: A Longitudinal Study

“…Adults spent a mean of 8.2 hours per day (range 4.9–11.9 h/day) in SB during waking hours (i.e., excluding the sleep period) [ 2 , 3 ]. Extended periods of time spent in SB activities have been associated with the development of cardiovascular diseases, diabetes type 2, and a high risk of mortality [ 4 , 5 ]. The mortality rate is increased by 2% for each hour sitting and increased further (almost 8%) if the sitting time is more than 8 h a day [ 6 ].…”

Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study

“…In the general adult population, self-reported MVPA took longer than APA [ 53 ]. PA data obtained from self-reported MVPA and APA differed conceptually, and these differences increased with activity and intensity levels [ 54 ]. This discrepancy regarding causality with myopia may be justified by these possibilities.…”

Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study

“…Firstly, LST people often have abnormal eating habits, they usually don’t have a habit of breakfast and the intake of vitamin and dietary fiber in the diet is low, fat composition is relatively high [ 32 ].These irregular eating habits can induce the formation of gallstones [ 33 ] and gallstones is the most common trigger of AP in advanced countries [ 34 ]. Secondly, A recent Mendelian randomization study has demonstrated that LST increases the risk of type 2 diabetes causally [ 35 ]. Dipeptidylpeptidase-4 (DPP4) inhibitors and Glucagon-like peptide-1 receptor agonist (GLP-1RAs) are important treatments for T2D.These medicines may increase the risk of pancreatitis [ 36 , 37 ].…”