Physical activity plays a crucial role in multidomain intervention for frailty prevention

Abstract

Background and Aims Taiwan is one of the most rapidly aging countries worldwide. Both physical activity and frailty affect older adults, and multidomain interventions prevent frailty. This study investigated the associations between physical activity, frailty, and the effects of multidomain intervention. Methods This study enrolled individuals aged 65 years or older. The physical activity level was assessed using the Physical Activity Scale for the Elderly (PASE). Enrollees participated in a multidomain intervention program that consisted of twelve 120-min sessions administered over a 12-week period that included health education, cognitive training, and exercise programs. The effects of the intervention were evaluated using the instrumental activities of daily living scale (IADL), Mini Nutritional Assessment short form (MNA–SF), five-item Geriatric Depression Scale (GDS–5), Mini-Mental State Examination (MMSE), timed up and go test (TUGT), and Fried’s frailty phenotype. Results In total, 106 older adults (aged 65–96 years) were enrolled in this study. The mean age was 77.47 ± 7.19 years, and 70.8% of participants were women. PASE scores were significantly lower among participants who were of older age, frail, and had a history of falls in the last 12 months. Frailty could be improved by multidomain interventions and was significantly positively correlated with depression, and negatively correlated with physical activity, mobility, cognition and daily living skills. Moreover, daily living skills were significantly positively correlated with cognition, mobility and physical activity, and negatively correlated with age, sex, and frailty. However, multidomain interventions did not affect daily living skills suggesting daily living skills may need to be maintained from a young age. Finally, results from multiple regressions suggest that physical activity, mobility and depression may be predictors of frailty. Conclusions Physical activity has an important role in frailty, may be a predictor of frailty, and strongly contributes to reducing frailty through multidomain intervention. Policies that encourage healthy aging should focus on increasing physical activity, maintaining basic daily living skills and reducing frailty.

The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study

“…Our study expands on previous studies that have reported improvement in physical function, frailty, and reduction in inflammation using behavioral lifestyle interventions (ie, diet and physical activity). 19 - 21 A review article investigated the effects of lifestyle interventions and reported improvement in proinflammatory cytokines, such as TNF-α and IL-6 (important mediators of inflammaging). 22 Our results support this data by showing an association between intentional weight loss prescribed through our behavioral intervention and significant improvements in several inflammatory cytokines and frailty.…”

Cognitive frailty and its association with disability among Chinese community-dwelling older adults: a cross-sectional study

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Mediating effects of depression on sleep disturbance and frailty in older adult type 2 diabetes patients in the community

“…Therefore, providing adequate sleep security is an effective strategy to reduce frailty in older adult T2DM patients. Furthermore, lifestyle modifications, appropriate diabetes management, and increased social interaction may help to reduce frailty among older adult T2DM patients with poor sleep quality ( 49 , 50 ).…”