Physical activity in daily life in patients with idiopathic pulmonary fibrosis

Nishiyama, Osamu; Yamazaki, Ryo; Sano, Hiroyuki; Iwanaga, Takashi; Higashimoto, Yuji; Kumakura, Hiroaki; Tohda, Yuji

doi:10.1016/j.resinv.2017.09.004

Cited by 38 publications

(58 citation statements)

References 30 publications

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“…Malnutrition has been identified in nearly one-third of IPF patients (Jouneau et al 2019). IPF patients have also been reported as significantly inactive compared with age-matched healthy individuals (Nishiyama et al 2018). In addition, common comorbidities of IPF such as diabetes and renal and cardiac failure induce muscle wasting (Cohen et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Appendicular Skeletal Muscle Mass Correlates with Patient-Reported Outcomes and Physical Performance in Patients with Idiopathic Pulmonary Fibrosis

Ebihara

Iwanami

Yamasaki

et al. 2021

Tohoku J. Exp. Med.

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Idiopathic pulmonary fibrosis (IPF), an incurable lung disease of unknown cause, often presents with losses of skeletal muscle mass. IPF requires comprehensive care, but it has not been investigated which skeletal muscle mass index reflects holistic management factors: pulmonary function, patient-reported outcomes (PROs), and physical performance. We compared three representative indices of skeletal muscle mass with holistic management factors in IPF patients. Twenty-seven mild to severe IPF patients (21 male) with the mean age of 76.1 ± 5.9 years were enrolled. The three indices were appendicular skeletal muscle mass index (ASMI), cross-sectional area of pectoralis major (PM CSA), and cross-sectional area of erector spinae muscles (ESM CSA). ASMI is considered as a gold standard for sarcopenia assessment, while PM CSA and ESM CSA are frequently used in IPF. As PROs, we assessed breathlessness with the modified Medical Research Council dyspnea scale (mMRC), symptoms with the chronic obstructive pulmonary disease assessment test (CAT), and health-related quality of life with St. George's Respiratory Questionnaire (SGRQ). For physical performance, peripheral muscle strength and 6-min walk distance (6MWD) were investigated. In this cross-sectional study, ASMI showed the greatest number of significantly correlated indices, such as pulmonary function, peripheral muscle strength, 6MWD, mMRC, and SGRQ. PM CSA showed the next greatest number of correlations, with peripheral muscle strength, 6MWD, and mMRC, whereas ESM CSA showed no significant correlations with any index. Thus, ASMI correlated with both PROs and physical performance, and PM CSA correlated mainly with physical performance. In conclusion, assessing ASMI is helpful for the comprehensive care of patients with IPF.

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Section: Discussionmentioning

confidence: 99%

Appendicular Skeletal Muscle Mass Correlates with Patient-Reported Outcomes and Physical Performance in Patients with Idiopathic Pulmonary Fibrosis

Ebihara

Iwanami

Yamasaki

et al. 2021

Tohoku J. Exp. Med.

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“…These changes are relevant, as they can affect the ability to do self-care, to walk, to engage in leisure activities and to work. Nishiyama et als’ prospective study showed that physical activity, expressed as steps taken, was significantly reduced in patients with IPF compared with healthy age-matched participants [ 164 ]. Lower daily physical activity also resulted in significantly worse survival in these patients.…”

Section: The Importance Of Comorbidities and Medical Conditions Assocmentioning

confidence: 99%

Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management

et al. 2021

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Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly subjects, and epidemiological studies suggest that the main risk factors, ageing and exposure to cigarette smoke, are associated with both pulmonary and extrapulmonary comorbidities (defined as the occurrence of two or more disorders in a single individual). Ageing and senescence, through interactions with environmental factors, may contribute to the pathogenesis of IPF by various mechanisms, causing lung epithelium damage and increasing the resistance of myofibroblasts to apoptosis, eventually resulting in extracellular matrix accumulation and pulmonary fibrosis. As a paradigm, syndromes featuring short telomeres represent archetypal premature ageing syndromes and are often associated with pulmonary fibrosis. The pathophysiological features induced by ageing and senescence in patients with IPF may translate to pulmonary and extrapulmonary features, including emphysema, pulmonary hypertension, lung cancer, coronary artery disease, gastro-oesophageal reflux, diabetes mellitus and many other chronic diseases, which may lead to substantial negative consequences in terms of various outcome parameters in IPF. Therefore, the careful diagnosis and treatment of comorbidities may represent an outstanding chance to improve quality of life and survival, and it is necessary to contemplate all possible management options for IPF, including early identification and treatment of comorbidities.

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“…Presumably RH adversely affects a patient's lung function, which results in decreased activities of daily living (ADL). Decreased lung function and decreased ADL are associated with poor survival [20,21]. Repeated RHs seem to more adversely affect subsequent long-term survival than short-term survival.…”

Section: Plos Onementioning

confidence: 99%

Characteristics of patients with chronic idiopathic interstitial pneumonia undergoing repeated respiratory-related hospitalizations: A retrospective cohort study

Yamazaki¹,

Nishiyama²,

Saeki³

et al. 2020

PLoS ONE

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Background Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease. Chronic idiopathic interstitial pneumonia (c-IIP) is a group of lung diseases consisting mainly of fibrotic IIPs, and IPF is a type of c-IIP. Some patients with c-IIP undergo respiratory-related hospitalizations (RHs). With the hypothesis that the characteristics of patients who undergo RHs are related to the number of hospitalizations, we reviewed and investigated the RHs of patients with c-IIP. Methods We retrospectively examined the data of patients with c-IIP who were admitted to Kindai University Hospital between January 2008 and December 2018 for respiratory-related causes. Results During the study period, 243 patients with c-IIP were hospitalized a total of 544 times because of respiratory-related causes. The most common reasons for the first RH were acute exacerbation (48.1%) followed by pulmonary infection (32.5%). The most frequent reason for subsequent RHs was pulmonary infection. The in-hospital and 90-day mortality rate of patients with pulmonary infection increased with increasing numbers of RHs. Patients with multiple RHs had significantly worse long-term survival than patients hospitalized a single time. Conclusions Pulmonary infection was the most frequent reason for repeated RHs. The proportion of all patients hospitalized for pulmonary infection at each RH increased with increasing numbers

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Physical activity in daily life in patients with idiopathic pulmonary fibrosis

Cited by 38 publications

References 30 publications

Appendicular Skeletal Muscle Mass Correlates with Patient-Reported Outcomes and Physical Performance in Patients with Idiopathic Pulmonary Fibrosis

Appendicular Skeletal Muscle Mass Correlates with Patient-Reported Outcomes and Physical Performance in Patients with Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management

Characteristics of patients with chronic idiopathic interstitial pneumonia undergoing repeated respiratory-related hospitalizations: A retrospective cohort study

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