Physical activity in children and adolescents with Charcot-Marie-Tooth disease: A cross-sectional case-controlled study

Abstract

Authors' contributionsRAK, JLM, KC, KLP and JB were involved in the study conceptualization and design.MMR and JB provided study resources including clinic patients. RAK, KC and KR were responsible for recruitment and assessment of participants. RAK was responsible for data analysis and original draft preparation. All authors were responsible for review and editing of the manuscript. Abstract Background: Disability related to the progressive and degenerative neuropathies known as Charcot-Marie-Tooth disease (CMT) affects gait and function, increasing with age and influencing physical activity in adults with CMT. The relationship between disease, ambulatory function and physical activity in children and adolescents with CMT is unknown. Method: A cross-sectional case-controlled study of 50 children with CMT and age-and gender-matched typically developing (TD) controls [mean age 12.5 (SD 3.9) years]. A 7-day recall questionnaire assessed physical activity; disease severity and gait-related function were measured to explore factors associated with physical activity. Results: Children with CMT were less active than TD controls (estimated weekly moderate to vigorous physical activity CMT 283.6 (SD 211.6) mins, TD 318.0 (SD 202.5) mins; p < 0.001). The children with CMT had moderate disability [CMT Pediatric Scale mean score 20 (SD 8) /44] and reduced ambulatory capacity in a sixminute walk test [CMT 485.1 (SD 160.9) metres, TD 639.8 (83.1) metres; p < 0.001].Physical activity correlated with greater disease severity (ρ = -0.52, p < 0.001) and sixminute walk distance (ρ = 0.71, p < 0.001).Conclusions: Disease-related disability affects physical activity and gait-related function in children and adolescents with CMT compared to TD peers. Reduced physical activity adversely affects function across the timespan of childhood and adolescence into adulthood.