Physical activity for women with breast cancer after adjuvant therapy

Lahart, Ian; Metsios, George S.; Nevill, Alan M.; Carmichael, Amtul R.

doi:10.1002/14651858.cd011292

Cited by 62 publications

(98 citation statements)

References 50 publications

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“…Insidiously, this physical inactivity contributes not only to physiological deconditioning, psychological and social consequences of cancer described above but also to long term deleterious effects associated with increased mortality and recurrence risk, thus constituting a major public health issue. In this sense, different meta-analyses seem to report a positive association between the practice of PA after diagnosis, improvement of survival and decreased risk of recurrence [15,[21][22][23][24][25]. These data contribute to the emerging idea that PA may be considered as a speci ic adjuvant therapy in cancer with a potential antitumor role [17].…”

Section: Introductionmentioning

confidence: 81%

“…These data contribute to the emerging idea that PA may be considered as a speci ic adjuvant therapy in cancer with a potential antitumor role [17]. Even if the bene its of PA on survival and the risk of recurrence after cancer treatment is largely disseminated and admitted in public communication, some authors highlighted numerous methodological limitations and large variability of proofs between the different cancer type suggesting that these data must be taken with caution [14,16,23,26]. Now regarding all these parameters, the issue well recognized in the scienti ic community is to conduct randomized controlled trials with rigorous methodologies to optimize the current recommendations and to de ine APA programs that can be integrated into the "real life" care of cancer patients.…”

Section: Introductionmentioning

confidence: 90%

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Role of physical activity in cancer survival and recurrence: A narrative review from relationship evidence to crucial research perspectives

Maury¹,

Sénesse²,

Ninot³

2018

J Sports Med Ther

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Purpose:The benefi ts of Physical Activity (PA) considered as a major supportive care in cancer patients, on survival, and recurrence risk is largely disseminated in public communication. However, these data must be taken with caution. The main objectives were to review the evidence and limits of studies reported regarding the post-diagnosis PA role on cancer survival and recurrence risk to secondly discuss of research perspectives on PA programs. Method:The narrative review included all published or ongoing studies in English during the last 20 years related to PA, survival and recurrence risk with a systematic search on main databases. Results and discussion:The current evidences regarding the PA role on survival and recurrence risk were only based on cohort studies, mainly in breast cancer. The major methodological limits identifi ed as the lack of PA change assessment, PA level assessed largely by self-reported methods and the signifi cant inter-but also intra-variability make the interpretation of data very. Beyond the use of rigorous RCT, the major issue is to develop adapted and personalized interventions to progressively increase PA level overtime in cancer survivors. Conclusion:Despite the lack of causal relationship between post-diagnosis PA, survival and recurrence risk, the review underlines several interesting research perspectives. The future PA interventions, using innovative tools and integrated to the "real-life" will argued for the potential antitumoral PA role growing in literature.

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Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 90%

Role of physical activity in cancer survival and recurrence: A narrative review from relationship evidence to crucial research perspectives

Maury¹,

Sénesse²,

Ninot³

2018

J Sports Med Ther

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“…Cheng, Lim, Koh, and Tam (2017) found that home-based multidimensional exercise interventions were effective in enhancing breast cancer-related quality of life. Lahart, Metsios, Nevill, and Carmichael (2018) reported that physical activity interventions might have moderate objective beneficial effects on quality of life and measured physical activity. Shobeiri, Masoumi, Nikravesh, Heidari Moghadam, and Karami (2016) found that exercise intervention was effective in improving the functional areas of cancerrelated quality of life, such as body image (P < 0.001), sexual function (P = 0.008), sexual pleasure (P = 0.030), and future prospect (P < 0.001), (P < 0.001), as well as the systemic side-effects of treatment ((P < 0.001), breast symptoms (P < 0.001), arm symptoms (P < 0.001), and worry about hair loss (P < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Effects of exercise training and follow‐up calls at home on physical activity and quality of life after a mastectomy

Nemli

Kartın

2018

Japan Journal Nursing Sci

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Aim To determine the effects of exercise training that was supported with follow‐up calls at home on the postoperative level of physical activity and quality of life of women with breast cancer. Methods The study was carried out with a quasi‐experimental design. Women who had underwent an axillary dissection and mastectomy and who were receiving ongoing chemotherapy treatment in the ambulatory unit of a university hospital were included in the study. Sixty‐two women were randomly assigned to an intervention (n = 31) or a control (n = 31) group. The women in the intervention group were given exercise training and then they were followed up by phone calls at home for 12 weeks in order to ensure the continuity of the exercises. Results At the end of the study, the number of “very active” individuals and the “total physical activity level” increased significantly in the intervention group but decreased significantly in the control group. In the intervention group, “future healthy function” in the functional area subscale significantly increased but “systematic therapy side‐effects,” “breast symptoms,” and “arm symptoms” in the symptom subscale increased significantly. Conclusion Exercise training that is supported with home follow‐up calls after surgery increases the level of physical activity, which then favorably relates with a good quality of life of women with breast cancer.

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“…Eight systematic reviews published between 2011 and 2018 were screened for RCTs [17e24]. RCTs were eligible when the effect of a supervised exercise intervention on quality of life in inactive and/or sedentary breast cancer survivors after primary treatment was evaluated [18,19]. Studies investigating yoga and pilot studies were excluded.…”

Section: Conventional Pragmatic Exercise Oncology Rctsmentioning

confidence: 99%

“…The latter investigated a 12-month intervention, whereas duration in the other conventional RCTs was !6 months. Other comorbidities 19 (28) 4 (21) No comorbidities 13 (19) Abbreviations: COPD, chronic obstructive pulmonary disease; UM-BRELLA, Utrecht cohort for Multiple BREast cancer intervention studies and Long-term evaLuAtion. a Limitations that were present before the start of the intervention in patients who accepted the intervention.…”

Section: Participation and Loss To Follow-upmentioning

confidence: 99%

The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting

Gal

Monninkhof

Gils

et al. 2019

Journal of Clinical Epidemiology

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Objectives: The Trials within Cohorts (TwiCs) design is an alternative for pragmatic randomized controlled trials (RCTs) and might overcome disadvantages such as difficult recruitment, dropout after randomization to control, and contamination. We investigated the applicability of the TwiCs design in an exercise oncology study regarding the recruitment process, representativeness of the study sample, contamination, participation, and dropout.Methods: The Utrecht cohort for Multiple BREast cancer intervention studies and Long-term evaLuAtion (UMBRELLA) Fit TwiCs evaluates an exercise intervention in inactive breast cancer patients. Eligible patients participating in the prospective UMBRELLA were identified and randomized. Patients randomized to the intervention (n 5 130) were offered the intervention, whereas controls (n 5 130) were not informed.Results: Fifty-two percent (n 5 68) accepted the intervention. Because this rate was lower than expected, a larger sample size was required than initially estimated (n 5 166). However, recruitment of 260 patients was still completed by one researcher within 30 months. Unselective eligibility screening and randomization before invitation improved representativeness. Disadvantage of the design might be inclusion of ineligible patients when cohort information is limited. Furthermore, the design faced higher noncompliance in the intervention group, but prevention of contamination.Conclusion: The TwiCs design improved logistics in recruitment and prevented contamination, but noncompliance due to refusal of the intervention was higher compared with conventional pragmatic exercise oncology RCTs, which may dilute the estimated intervention

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Physical activity for women with breast cancer after adjuvant therapy

Cited by 62 publications

References 50 publications

Role of physical activity in cancer survival and recurrence: A narrative review from relationship evidence to crucial research perspectives

Role of physical activity in cancer survival and recurrence: A narrative review from relationship evidence to crucial research perspectives

Effects of exercise training and follow‐up calls at home on physical activity and quality of life after a mastectomy

The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting

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