Physical Activity, Fatty Liver, and Glucose Metabolism Over the Life Course: The Lifelines Cohort

Byambasukh, Oyuntugs; Zelle, Dorien M.

doi:10.14309/ajg.0000000000000168

Cited by 23 publications

(30 citation statements)

References 43 publications

(18 reference statements)

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“…Within this RTR population, MVPA levels were lower than those within the general population. In our study, 38% of RTRs were inactive (no-MVPA), whereas in the Lifelines cohort, a population-based study for which the same questionnaire (SQUASH) and comparable data processing methods were used, the prevalence of inactivity (no-MVPA) was 10% (n = 125,402, 40.5% males, median age of 45) [30,49]. Even in different age groups and gender, it was lower, ranging between 7.5% (n = 42,661, 40% of males, median age of 40) and 12.5% (n = 34,506, 45.6% of males, median age of 56) in the Lifelines.…”

Section: Discussionmentioning

confidence: 81%

“…A growing body of evidence is showing that occupational MVPA may have no clear benefit on health in the general population [20][21][22]30,49]. This was tested in our study including a specific patient population, the RTR.…”

Section: Discussionmentioning

confidence: 99%

“…A clear mechanism that prevents occupational PA from generating health benefits is missing. There is always the possibility of residual confounding by factors such as sex, socioeconomic status, work-related stress, and body weight in the association between occupational PA and health outcomes [20,22,30,49]. Studies attempted to explore the possibility of residual confounding, but also found no clear association of occupational MVPA and health outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Physical Activity and the Development of Post-Transplant Diabetes Mellitus, and Cardiovascular- and All-Cause Mortality in Renal Transplant Recipients

Byambasukh

Osté

Gomes-Neto

et al. 2020

JCM

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(1) Background: Little is currently known about the health impacts of daily-life moderate-to-vigorous physical activity (MVPA) in relation to the development of post-transplant diabetes mellitus (PTDM) and the long-term survival of renal transplant recipients (RTRs). (2) Methods: We analyzed self-reported data on MVPA within non-occupational and occupational domains, estimated with the SQUASH questionnaire, from a prospective cohort study of RTRs (n = 650) with a functioning graft exceeding 1 year. PTDM diagnoses were based on plasma glucose levels (≥126 mg/dL), HbA1c (≥6.5%), and the use of antidiabetic medication. Mortality data were retrieved from patient files up to the end of September 2015. (3) Results: During a median follow-up period of 5.3 years, 50 patients (10%) developed PTDM and 129 (19.8%) died. Of these deaths, 53 (8.9%) were caused by cardiovascular disease. Cox regression analyses showed that higher MVPA levels among patients were associated with a lower risk of PTDM (hazard ratio (HR); 95% confidence interval (95%CI) = 0.49; 0.25–0.96, p = 0.04), cardiovascular- (0.34; 0.15–0.77, p = 0.01), and all-cause mortality (0.37; 0.24–0.58, p < 0.001) compared with No-MVPA patients, independently of age, sex, and kidney function parameters. Associations of MVPA with cardiovascular and all-cause mortality remained significant and materially unchanged following further adjustments made for transplant characteristics, lifestyle factors, metabolic parameters, medication use, and creatinine excretion (muscle mass). However, the association between MVPA and PTDM was no longer significant after we adjusted for metabolic confounders and glucose levels. (4) Conclusion: Higher MVPA levels are associated with long-term health outcomes in RTRs.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Physical Activity and the Development of Post-Transplant Diabetes Mellitus, and Cardiovascular- and All-Cause Mortality in Renal Transplant Recipients

Byambasukh

Osté

Gomes-Neto

et al. 2020

JCM

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“…However, regarding the dose‐effect relationship of sport participation, research has been ambiguous 41 . While some studies 22,42 find positive dose‐response associations for PA in general, others show no dose effects 16 or even negative effects for very high volumes of PA 15 . Fifth, we do not control for several unavailable potential confounding variables, such as DNA or diseases that may influence the health outcomes (mortality in particular).…”

Section: Discussionmentioning

confidence: 99%

How is sport participation related to mortality, diabetes and prediabetes for different body mass index levels?

Boer

Corpeleijn

Dekker

et al. 2021

Scandinavian Med Sci Sports

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“…Furthermore, it is not clear whether all types of activities can contribute to the recommended amount of daily PA as there is emerging evidence that occupational moderate-to-vigorous PA (MVPA) may not have the same level of health bene ts as do physical activities conducted at leisure-time. [24] [25] [26][27] "As mentioned above, since it is not clear in previous studies whether the effects of MVPA prevent weight gain depending on whether it is more moderate or vigorous intensity activities, the primary objective of our study is to determine whether the association of MVPA on body weight gain are more dependent on moderate and vigorous physical activities. In case that the association of MVPA depends on its intensity, we explored how it relates to the types of activities reported by the participants."…”

Section: Introductionmentioning

confidence: 99%

Physical activity and 4-year changes in body weight in 52,498 non-obese people: The Lifelines Cohort

Byambasukh

Vinke

Kromhout

et al. 2020

Preprint

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Objectives: We investigated associations between leisure-time physical activity (LTPA) at different intensities (moderate and vigorous or moderate-to-vigorous) and prospective weight gain in non-obese people. We also examined whether these associations were independent of other lifestyle factors and changes in muscle mass and whether they were age-dependent and changed over a person’s life course.Methods: The data were extracted from the Lifelines cohort study (N=52,498; 43.5% men) and excluded obese individuals (BMI>30kg/m2). We used the validated SQUASH questionnaire to estimate moderate-to-vigorous (MVPA; MET≥4), moderate (MPA; MET between 4 and 6.5) and vigorous PA (VPA; MET≥6.5). Body weight was objectively measured, and changes were standardized to a 4-year period. Separate analyses, adjusted for age, educational level, diet, smoking, alcohol consumption and changes in creatinine excretion (a marker of muscle mass), were performed for men and women.Results: The average weight gain was +0.45±0.03 kg in women. Relative to each reference groups (No-MVPA, No-MPA and No-VPA), MVPA (Beta (95%CI): -0.34 kg (-0.56;-0.13)), MPA (-0.32 kg (-0.54;-0.10)) and VPA (-0.30 kg (-0.43;-0.18)) were associated with less gain in body weight in women after adjusting for potential confounders, described above. These associations were dose-dependent when physically active individuals were divided in tertiles. Beta-coefficients (95%CI) for the lowest, middle, and highest MVPA tertiles relative to the ‘No-MVPA’ were, respectively, -0.24 (-0.47;-0.02), -0.31 (-0.53;-0.08), and -0.38 (-0.61;-0.16) kg. The average weight gain in men was +0.13±0.03 kg, and only VPA, not MPA was associated with less body weight gain. Beta-coefficients (95%CI) for the VPA tertiles relative to the ‘No-VPA’ group were, respectively, -0.25 (-0.42;-0.09), -0.19 (-0.38;-0.01) and -0.20 (-0.38;-0.02) kg. However, after adjusting for potential confounders, the association was no longer significant in men. The potential benefits of leisure-time PA were age-stratified and mainly observed in younger adults (men: <35 years; women: <55 years). Moreover, occupational MVPA was not associated with favourable changes in body weight in males and females.Conclusion: Higher leisure-time MVPA, MPA, and VPA were associated with less weight gain in women <55 years. In younger men (<35 years), only VPA was associated with less weight gain.

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Physical Activity, Fatty Liver, and Glucose Metabolism Over the Life Course: The Lifelines Cohort

Cited by 23 publications

References 43 publications

Physical Activity and the Development of Post-Transplant Diabetes Mellitus, and Cardiovascular- and All-Cause Mortality in Renal Transplant Recipients

Physical Activity and the Development of Post-Transplant Diabetes Mellitus, and Cardiovascular- and All-Cause Mortality in Renal Transplant Recipients

How is sport participation related to mortality, diabetes and prediabetes for different body mass index levels?

Physical activity and 4-year changes in body weight in 52,498 non-obese people: The Lifelines Cohort

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