Physical Activity, Exercise and Breast Cancer - What Is the Evidence for Rehabilitation, Aftercare, and Survival A Review

Wirtz, Petra H.; Baumann, Freerk T.

doi:10.1159/000488717

Cited by 59 publications

(47 citation statements)

References 69 publications

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“…Other diets such as Okinawan and plant-based diets, low energy density, and low glycemic load dietary patterns are associated with BC prevention and better prognosis [32]. In the same manner, different studies have highlighted the protective role of exercise, which is able to reduce BC incidence and mortality inducing both genetic and epigenetic modulation [33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Falzone

Grimaldi

Celentano

et al. 2020

Cancers

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Background: Several studies have shown that healthy lifestyles prevent the risk of breast cancer (BC) and are associated with better prognosis. It was hypothesized that lifestyle strategies induce microRNA (miRNA) modulation that, in turn, may lead to important epigenetic modifications. The identification of miRNAs associated with BC, diet, and physical activity may give further insights into the role played by lifestyle interventions and their efficacy for BC patients. To predict which miRNAs may be modulated by diet and physical activity in BC patients, the analyses of different miRNA expression datasets were performed. Methods: The GEO DataSets database was used to select miRNA expression datasets related to BC patients, dietary interventions, and physical exercise. Further bioinformatic approaches were used to establish the value of selected miRNAs in BC development and prognosis. Results: The analysis of datasets allowed the selection of modulated miRNAs associated with BC development, diet, and physical exercise. Seven miRNAs were also associated with the overall survival of BC patients. Conclusions: The identified miRNAs may play a role in the development of BC and may have a prognostic value in patients treated with integrative interventions including diet and physical activity. Validation of such modulated miRNAs on BC patients undergoing lifestyle strategies will be mandatory.

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Section: Introductionmentioning

confidence: 99%

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Falzone

Grimaldi

Celentano

et al. 2020

Cancers

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“…In this respect, the gold standard for the evaluation of BCF is self-reporting using scales, questionnaires, and/or inventories (13). Regrettably, the great heterogeneity in these diagnostic methods, coupled with the lack of widely adopted guidelines, represents a major limitation in the clinical management of BCF (13,14).…”

Section: Introductionmentioning

confidence: 99%

Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study

et al. 2020

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Breast cancer fatigue (BCF) is a complex and multidimensional condition characterized by a persistent sense of physical and/or mental stiffness, resulting in a substantial impairment of health-related quality of life in breast cancer survivors. Aim of this prospective cohort study was to evaluate the feasibility and the effectiveness of a 4-week rehabilitation protocol on BCF, muscle mass, strength, physical performance, and quality of life in breast cancer (BC) survivors. We recruited adult BC women with a diagnosis of BCF, according to the International Classification of Diseases 10 criteria, referred to the Outpatient Service for Oncological Rehabilitation of a University Hospital. All participants performed a specific physical exercise rehabilitative protocol consisting of 60-min sessions repeated 2 times/week for 4 weeks. All outcomes were evaluated at the baseline (T0), at the end of the 4-week rehabilitation treatment (T1), and at 2 months follow up (T2). The primary outcome measure was the Brief Fatigue Inventory (BFI); secondary outcomes included: Fat-Free Mass and Fat Mass, assessed by Bioelectrical Impedance Analysis (BIA); Hand Grip Strength Test (HGS); Short Physical Performance Battery (SPPB); 10-meter walking test (10 MWT); 6-min walking test (6 MWT); European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Thirty-six women (mean age: 55.17 ± 7.76 years) were enrolled in the study. Significant reduction of BCF was observed both after the 4-week rehabilitation treatment (T1) (BFI: 5.4 ± 1.6 vs. 4.2 ± 1.7; p = 0.004) and at the follow-up visit (T2) (BFI: 5.4 ± 1.6 vs. 4.4 ± 1.6; p = 0.004). Moreover, significant differences (p < 0.001) HGS, SPPB, 10 MWT, 6 MWT, and EORTC QLQ-C30 were found at T1, while at T2 all the outcome measures were significantly different (p < 0.05) from the baseline. The rehabilitation protocol seemed to be feasible, safe, and effective in reducing BCF, improving muscle mass and function, and improving HRQoL in a cohort of BC survivors. The results of this study could improve awareness of this underestimated disease, suggesting the definition of a specific therapeutic exercise protocol to reduce BCF.

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“…The BMI was not correlated with the ratio to the predicted 6MWT. It is thought that the weight of breast cancer patients within 1 year after surgery is not influenced by a reduction in aerobic clearly as in other studies (Brown et al, 2015;Simonavice et al, 2015;Wirtz & Baumann, 2018). Fatness and decreased physical activity are known to be associated with mortality and recurrence of breast cancer (de Boer, Wörner, Verlaan, & Leeuwen, 2017).…”

Section: Discussionmentioning

confidence: 82%

“…It has been shown that arm impairments such as flexibility, strength and oedema are present in breast cancer patients within 1 year after surgery, but it does not affect overall QOL, physical activity and fatness. However, even if it does not affect overall QOL, physical activity and fatness, it would be necessary to provide appropriate intervention because there were groups with impairment clearly as in other studies (Brown et al, ; Simonavice et al, ; Wirtz & Baumann, ). Fatness and decreased physical activity are known to be associated with mortality and recurrence of breast cancer (de Boer, Wörner, Verlaan, & Leeuwen, ).…”

Section: Discussionmentioning

confidence: 96%

Aerobic capacity correlates with health‐related quality of life after breast cancer surgery

Kim

Park

2019

Eur J Cancer Care

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To investigate the relation of physical functions to health‐related quality of life (HRQOL), physical activity and fatness of patients during breast cancer treatment within 1 year after surgery. We retrospectively reviewed the patients with breast cancer at the cancer rehabilitation clinic within 1 year after surgery. Physical function assessment included aerobic capacity, muscle strength, flexibility and oedema. Physical activity was assessed using the International Physical Activity Questionnaire‐Short Form, and HRQOL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Stepwise multivariate linear regression analysis was used to find the association factors. Of the physical functions in subjects, aerobic capacity was 88.64% compared to predictive value. The mean overall QOL was 60.82 ± 20.98. The mean physical activity was 2,245.49 ± 3,687.66 MET/week and 39 patients (41.5%) were inactive. As the results of stepwise multivariate linear regression analysis, aerobic capacity was a significant factor of HRQOL and physical activity. The impairment of physical functions affects the HRQOL of patients within 1 year after breast cancer surgery. Among the physical functions, the decrease in aerobic capacity was significantly associated with the decrease in the overall QOL of the patients.

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Physical Activity, Exercise and Breast Cancer - What Is the Evidence for Rehabilitation, Aftercare, and Survival A Review

Cited by 59 publications

References 69 publications

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study

Aerobic capacity correlates with health‐related quality of life after breast cancer surgery

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