Physical activity during treatment in children with leukemia: a pilot study

Aznar, Susana; Webster, Anthony L.; Juan, Alejandro San JuanA.F. San F.; Chamorro-Viña, Carolina; Maté-Muñoz, José Luis; Moral, Susana; Pérez, Margarita; García‐Castro, Javier; Ramı́rez, Manuel; Madero, Luís; Lucı́a, Alejandro

doi:10.1139/h06-014

Cited by 73 publications

(72 citation statements)

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“…These results are in accordance with those of Aznar et al, who also found a lower physical activity in ALL patients compared to healthy controls [2]. As far as we know, there are no further studies on physical activity measured in ALL patients on treatment.…”

Section: Discussionsupporting

confidence: 93%

Acute lymphoblastic leukemia and obesity: increased energy intake or decreased physical activity?

Jansen

Postma

Stolk

et al. 2008

Support Care Cancer

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Background Obesity is a well-known problem in children with acute lymphoblastic leukemia (ALL), and it might be the result of an excess in energy intake, reduced energy expenditure, or both. The aim of this study is to describe energy intake and physical activity during treatment for ALL with intermittent dexamethasone (DEXA). Methods Body mass index (BMI), energy intake, and physical activity were measured in 16 ALL patients on maintenance treatment and in 17 healthy controls. ALL patients were measured during ("on DEXA") and in between ("off DEXA") DEXA treatments. Results In patients, the mean increase in BMI z-score was 1.4±1.1. Energy intake on DEXA was higher (2,125.9± 476.0 vs 1,775.1±426.1 kcal/24 h, p<0.05) and energy intake off DEXA was lower (1,305.0±249.4 vs 1,775.1± 426.1 kcal/24 h, p<0.05), compared to healthy controls. Physical activity on DEXA was lower compared to healthy controls (30.0±3.9 vs 40.0±6.0 kcal kg −1 24 h −1 , p<0.001and 7,303.1±4,622.9 vs 13,927.2±3,822.7 steps, p<0.05). Physical activity off DEXA was not different compared to healthy controls. Conclusion Weight gain in patients on ALL treatment might be owing to increased energy intake and decreased physical activity during treatment with DEXA.

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Section: Discussionsupporting

confidence: 93%

Acute lymphoblastic leukemia and obesity: increased energy intake or decreased physical activity?

Jansen

Postma

Stolk

et al. 2008

Support Care Cancer

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“…Children undergoing the early stages of treatment have reduced PA, mainly because of the constraints associated with hospitalization, which include medical apparatus, and side effects from intensive treatment regimes, such as fatigue and nausea, which lead to sedentary bed rest. 37,38 A spectrum of disuse, and overprotective parents and physicians monitoring children in remission, may contribute to patterns of inactivity persisting after treatment is completed. 39 Although five children in the current study had PAQ-C scores lower than published mean scores for children without a cancer diagnosis (mean score 3.2), 22 two children had comparable scores, and six achieved higher scores.…”

Section: Discussionmentioning

confidence: 99%

Associating Physical Activity Levels with Motor Performance and Physical Function in Childhood Survivors of Acute Lymphoblastic Leukemia

Hung

Rankin

Virji‐Babul

et al. 2017

Physiotherapy Canada

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Purpose: This cross-sectional, observational study investigated whether physical activity (PA) levels are associated with motor performance and physical function in children after treatment for acute lymphoblastic leukemia (ALL). Method: Participants aged 8-13 years who had completed treatment for ALL (3-36 months post-treatment) were tested at their oncology long-term follow-up appointment at the British Columbia Children's Hospital. PA level was measured using the Physical Activity Questionnaire for Older Children (PAQ-C). Motor performance was measured using the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition, Short Form (BOT-2 SF), and physical function was measured using the 6-minute walk test (6MWT). Results: Thirteen children completed testing. PAQ-C scores were not associated with BOT-2 SF or 6MWT performance. Eleven children (85%) performed below the norm for the 6MWT. Children with elevated body mass index had poorer 6MWT but similar PAQ-C scores. Conclusion: PA was not found to be associated with motor performance and physical function. Participants who were overweight or obese had poorer 6MWT performance, which may indicate the need for closer monitoring of post-treatment weight status and physical function in the oncology follow-up setting.Key Words: acute lymphoblastic leukemia; body mass index; motor skills; physical activity; physical fitness. RÉ SUMÉObjectif : cette é tude observationnelle à mé thodologie transversale portait sur le lien potentiel entre le niveau d'activité physique (AP) et la capacité motrice et physique des enfants ayant reç u un traitement contre la leucé mie lymphoblastique aiguë (LLA). Mé thode : des participants â gé s de 8 à 13 ans ayant reç u un traitement contre la LLA (de 3 à 36 mois aprè s le traitement) ont é té é valué s lors de leur rendez-vous de suivi à long terme en oncologie au British Columbia Children's Hospital. Le niveau d'AP a é té mesuré à l'aide du Questionnaire de mesure de l'activité physique chez les enfants (PAQ-C). La capacité motrice a é té mesuré e à l'aide du Bruininks-Oseretsky Test of Motor Proficiency, Deuxiè me é dition, Formulaire court (BOT-2 SF) et la capacité physique a é té mesuré e à l'aide du test de marche de 6 minutes (6MWT). Ré sultats : treize enfants ont effectué les tests. Aucun lien n'a é té observé entre les scores du PAQ-C et les ré sultats du BOT-2 SF ni ceux du 6MWT. Onze enfants (85 %) ont obtenu un ré sultat infé rieur à la norme au 6MWT. Les enfants ayant un indice de masse corporelle é levé ont obtenu des ré sultats plus faibles au 6MWT, mais des ré sultats similaires au PAQ-C. Conclusion : le niveau d'AP ne semble pas avoir de lien avec la capacité motrice ou physique. Les participants en surpoids et obè ses ont obtenu des ré sultats plus faibles au 6MWT, ce qui peut indiquer un besoin de surveillance plus é troit du poids et de la capacité physique aprè s le traitement lors des rendez-vous de suivi en oncologie.Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy in Canada, a...

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“…Inactivity (5-7), impaired cardiopulmonary and musculoskeletal function, as well as reduced motor performance levels (8,9) and cognitive abilities (10) have been detected. Current studies also examined a negative impact on psychological well-being, satisfaction, and social functioning (11). Taken together, an impaired quality of life can thus be determined (8,12).…”

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confidence: 99%

Clinical exercise interventions in pediatric oncology: a systematic review

2013

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Studies in pediatric oncology have shown a positive effect of physical activity on disease-and treatment-related side effects. Although several reviews have approved the benefits of therapeutic exercise for adult cancer patients, no systematic review exists summarizing the evidence of physical activity in pediatric oncology. We identified a total of 17 studies using the PubMed database and Cochrane library. To evaluate the evidence, we used the evaluation system of the Oxford Center for Evidence-Based Medicine 2001. The findings confirm that clinical exercise interventions are feasible and safe, especially with acute lymphoblastic leukemia (ALL) patients and during medical treatment. No adverse effects have been reported. Positive effects were found on fatigue, strength, and quality of life. Single studies present positive effects on the immune system, body composition, sleep, activity levels, and various aspects of physical functioning. Child-specific aspects such as cognitive abilities, growth, adolescence, and reintegration into peer-groups, school, and sports have barely been taken into consideration. The evidence for exercise interventions in pediatric oncology is rated level "3. " Although the results are very promising, future research of high methodological quality and focusing on child-specific aspects is needed to establish evidence-based exercise recommendations, particularly for childhood cancer patients.A s a result of improved treatment regimes in pediatric oncology, the survival rates of children with cancer have risen to ~80% for 5-y survival (1-4). Therefore, the population of childhood cancer survivors is constantly growing. Despite these positive developments, childhood cancer is associated with a wide spectrum of various disease-and treatment-related side effects that may develop into chronic diseases and therefore result in long-term consequences. A negative impact on social, psychological, and physiological levels can be observed. Inactivity (5-7), impaired cardiopulmonary and musculoskeletal function, as well as reduced motor performance levels (8,9) and cognitive abilities (10) have been detected. Current studies also examined a negative impact on psychological well-being, satisfaction, and social functioning (11). Taken together, an impaired quality of life can thus be determined (8,12).During the past few years, several studies have generated first hints describing holistic, positive effects of clinical exercise interventions in pediatric oncology. First results present an association between increased physical activity levels in childhood cancer patients and an improvement in quality of life (13). In particular, physical functioning is increased, anxiety is reduced, and social integration is encouraged (14). Considering the fact that physical activity plays a vital role in the physiological and psychosocial development of children, therapeutic exercise in pediatric oncology is particularly important. However, there is still a lack of comprehensive and evidence-based data in the field o...

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Physical activity during treatment in children with leukemia: a pilot study

Cited by 73 publications

References 28 publications

Acute lymphoblastic leukemia and obesity: increased energy intake or decreased physical activity?

Acute lymphoblastic leukemia and obesity: increased energy intake or decreased physical activity?

Associating Physical Activity Levels with Motor Performance and Physical Function in Childhood Survivors of Acute Lymphoblastic Leukemia

Clinical exercise interventions in pediatric oncology: a systematic review

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