Physical Activity and PDE5 Inhibitors in the Treatment of Erectile Dysfunction: Results of a Randomized Controlled Study

Maio, Giuseppe Di; Saraeb, Salim; Marchiori, Antonio

doi:10.1111/j.1743-6109.2010.01783.x

Cited by 81 publications

(72 citation statements)

References 41 publications

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“…Regular (43 h per week) aerobic non-agonistic physical activity in association with specific medication (phosphodiesterase type 5 inhibitor) has showed significant beneficial effects in the treatment of erectile dysfunction after 3 months compared with medication alone in 60 men (40-60 years) with erectile dysfunction. 28 In the present study, there has been association between physical fitness, assessed by indirect measurement of VO2max and erectile dysfunction, where men with better results for VO2max had less erectile dysfunction. Physical fitness is defined as the ability to perform physical activity of moderate through intense level without excessive fatigue and the capacity to maintain this ability throughout life.…”

Section: Discussionsupporting

confidence: 49%

Erectile dysfunction association with physical activity level and physical fitness in men aged 40–75 years

et al. 2011

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The aim of this study is to evaluate the association between physical activity level and physical fitness with erectile dysfunction in men aged 40-75 years. We examined 180 men aged 40-75 years. The individuals were evaluated for age, presence of dyslipidemia and smoking and for anthropometric parameters for the characterization of body mass index. For assessing the level of physical fitness, a test was performed to measure the indirect maximum oxygen consumption. The evaluation of erectile function was made by the International Index of Erectile Function questionnaire and assessment of physical activity level by the International Physical Activity questionnaire in its short version. This study showed that younger men with higher physical activity and better physical fitness are less likely to suffer from erectile dysfunction. Multivariable analysis through logistic regression showed that age (odds ratio (OD) ¼ 1.15; 95% confidence interval (95% CI) ¼ 1.07-1.23), physical activity (OD ¼ 10.38; 95% CI ¼ 3.94-27.39) and physical fitness (OD ¼ 4.62; 95% CI ¼ 1.75-12.25) were independent variables associated with erectile dysfunction. This study reinforces the concept that healthy habits have a direct effect on erectile function.

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Section: Discussionsupporting

confidence: 49%

Erectile dysfunction association with physical activity level and physical fitness in men aged 40–75 years

et al. 2011

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“…24,25 Maio et al showed that physical activity was the only independent variable for normal erection and higher sexual satisfaction. 26 Reduced physical activity is frequently seen in patients with COPD. 27 Our results revealed a positive correlation between IIEF score and IPAQ score, which means that the limitation of physical activity may also diminish the sexual activities in COPD patients.…”

Section: Discussionmentioning

confidence: 99%

Erectile dysfunction in COPD patients

2015

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Sexual dysfunction is a common problem in chronic obstructive pulmonary disease (COPD). We aimed to assess the presence of erectile dysfunction (ED) in COPD patients. Ninety-three outpatients who had been diagnosed as COPD and followed in Bolvadin State Hospital, Afyon, Turkey, were included in the study. All patients underwent pulmonary function tests and arterial blood gas analysis. They completed International Physical Activity Questionnaire (IPAQ), Medical Research Council (MRC) Dyspnea Scale, Short Form 36-item Scale (SF-36), and International Index of Erectile Function (IIEF) Questionnaire. The mean age of 10 (10.8%) mild, 46 (49.5%) moderate, 28 (30.1%) severe, and 9 (9.7%) very severe COPD patients was 61.4 + 9.8 years. Varying degrees of ED were detected in 67.7% of COPD patients. All patients with hypoxemia had ED. IPAQ score and all SF-36 parameters were low in patients with ED, while MRC score was high. Forced expiratory volume in one second, forced vital capacity, partial pressure of oxygen in blood, oxygen (O 2 ) saturation, IPAQ score, and role-physical parameters were statistically low in ED patients (p ¼ 0.04, 0.02, <0.01, <0.01, 0.02, and 0.04, respectively); MRC score was statistically higher in patients with ED (p ¼ 0.02). Patients with moderate and severe ED had statistically lower score of mental health (p < 0.01 and p ¼ 0.02, respectively). There was a positive correlation between IIEF score and IPAQ scores (p < 0.01), MRC scores (p ¼ 0.01), general health (p < 0.01), role-physical (p < 0.01), role-emotional (p < 0.01), physical functioning (p < 0.01), and mental health (p < 0.01) parameters in SF-36. ED is frequently seen in COPD patients. Hypoxemia, smoking, and limitation of physical activity are thought to be associated with ED in COPD as mechanisms. Quality of life and the functional capacity are negatively affected with the presence of ED. It is important for a physician to question the sexual functions in patients with COPD. The presence of ED may be routinely considered in the daily practice of pulmonologists in COPD patients. Keywords COPD, sexual functions, erectile dysfunction IntroductıonSince chronic obstructive pulmonary disease (COPD) is a chronic disease of middle-aged or older people, comorbidities are frequently seen. With decreasing sexual interest, testosterone levels and sexual function by aging, and the presence of chronic illnesses, erectile dysfunction (ED) is one of these comorbid diseases.ED is a frequent type of sexual dysfunction among mature and aging men, which is characterized by the inability to have an erection during sexual activity. A broad-based public study (Massachusetts Male Aging Study) revealed an ED prevalence as high as 52% in males between the fourth and seventh decade of life.1 Dunn et al. demonstrated that 34% of males (mean age 50) within the general population complained about sexual problems and the most common complaint was ED.2 Both studies showed that ED prevalence increases with age.The mechanism of ED is not exactly clarified in...

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“…The studies were performed in three continents: five from Europe,18 19 21 23 24 one from Asia20 and one in Africa 22. Follow-up ranged from 8 weeks to 2 years.…”

Section: Evidence Synthesismentioning

confidence: 99%

“…The mean age among participants ranged from 43 to 69 years. The mean severity of erectile dysfunction was identified as severe,20 24 moderate19 22 and mild to moderate18 21 23 according to the IIEF-5 classification of severity 10. Predisposing factors for erectile dysfunction also varied among studies: one described no predisposing conditions,24 two enrolled radical prostatectomy20 and invasively treated patients with ischaemic heart disease18, and the remainder included patients with one or more cardiovascular risk factors alone 19 21–23…”

Section: Evidence Synthesismentioning

confidence: 99%

“…Three trials evaluated physical activity without usual care for erectile dysfunction,20 23 24 while the remaining four combined physical activity with pharmacological treatment 18 19 21 22. Four studies included a specific and monitored exercise regimen18 19 22 24 and three consisted of unsupervised physical activity 20 21 23. The tool used to evaluate erectile dysfunction was homogeneous among studies since the IIEF questionnaire was applied in all studies.…”

Section: Evidence Synthesismentioning

confidence: 99%

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Physical activity and exercise for erectile dysfunction: systematic review and meta-analysis

et al. 2016

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Physical Activity and PDE5 Inhibitors in the Treatment of Erectile Dysfunction: Results of a Randomized Controlled Study

Cited by 81 publications

References 41 publications

Erectile dysfunction association with physical activity level and physical fitness in men aged 40–75 years

Erectile dysfunction association with physical activity level and physical fitness in men aged 40–75 years

Erectile dysfunction in COPD patients

Physical activity and exercise for erectile dysfunction: systematic review and meta-analysis

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