Physical activity and incidence of non-insulin-dependent diabetes mellitus in women

Manson, JoAnn E.; Stampfer, Meir J.; Colditz, Graham A.; Willett, Walter C.; Rosner, Bernard; Hennekens, Charles H.; Speizer, Frank E.; Rimm, Eric B.; Królewski, Andrzej S.

doi:10.1016/0140-6736(91)90664-b

Cited by 1,049 publications

(670 citation statements)

References 24 publications

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“…During the hyperinsulinaemic-euglycaemic clamp the insulin concentration increased to 81±11 and 141±24 pmol/l in the control subjects and the diabetic patients, respectively. The reduction of the [U- 13 C]palmitate infusion rate at the beginning of the clamp period successfully minimised the changes in palmitate enrichment expected from the effect of insulin infusion (Fig. 5).…”

Section: Insulin Concentration and Plasma Palmitate Enrichmentmentioning

confidence: 90%

“…Twenty minutes after the catheterisation procedure, baseline blood samples were taken and femoral and subclavian blood flow was measured by Doppler ultrasound [18]. Subsequently, a constant infusion of [U- 13 C]palmitate (0.009 μmol·kg −1 · min −1 ; Cambridge Isotope Laboratories, Andover, MA, USA) was started. The isotope infusion was continued for 9 h, during which time the subjects remained in the supine position.…”

Section: Methodsmentioning

confidence: 99%

“…During the hyperinsulinaemic clamp the arterial glucose concentration was maintained at the value recorded at the end of the baseline period (5.07±0.1 mmol/l in the control subjects and 6.86±1.0 mmol/l in the diabetic patients) by infusion of a 20% glucose solution. The [U- 13 C]palmitate infusion rate was reduced by 50% at the start of the hyperinsulinaemiceuglycaemic clamp. Arterial glucose and potassium concentrations were measured every 10 min during the clamp period (ABL 715; Radiometer, Copenhagen, Denmark) and potassium was infused to maintain the plasma potassium concentration.…”

Section: Methodsmentioning

confidence: 99%

“…Palmitate concentration was measured by gas chromatography with FID (Autosystem XL; Perkin Elmer, Northwalk, CT, USA), using heptadecanoic acid as an internal standard. Plasma palmitate 13 C enrichment was measured by gas chromatography-combustion isotope ratio mass spectrometry (GC-C-IRMS, Hewlett Packard 5890, Finnigan GC combustion III, Finnigan Delta plus ; Finnigan MAT, Bremen, Germany) as described previously [21]. Palmitate enrichment was corrected by a factor of 17/16 to account for the extra methyl group of the methyl palmitate derivative.…”

Section: Analytical Proceduresmentioning

confidence: 99%

“…Moreover, the relationship between intramuscular lipid accumulation and insulin resistance has been described [10,11]. Physical inactivity or muscle disuse is recognised as one of the risk factors for the development of insulin resistance and type 2 diabetes [12,13]. Against this, it has been shown that exercise training can reduce insulin resistance in the leg of diabetic patients [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Heterogeneity in limb fatty acid kinetics in type 2 diabetes

et al. 2005

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Aims/hypothesis: In order to test the hypothesis that disturbances in skeletal muscle fatty acid metabolism with type 2 diabetes are not equally present in the upper and lower limbs, we studied fatty acid kinetics simultaneously across the arm and leg of type 2 diabetic patients (n=6) and matched control subjects (n=7) for 5 h under baseline conditions and during a 4-h hyperinsulinaemiceuglycaemic clamp. Methods: Limb fatty acid kinetics was determined by means of continuous [U-13 C]palmitate infusion and measurement of arteriovenous differences. Results: The systemic palmitate rate of appearance was 3.6±0.4 and 2.7±0.3 μmol·kg lean body mass −1 ·min −1 and decreased during the clamp by 26% (p=0.04) and 43% (p<0.01) in the diabetic patients and in the control subjects respectively. At baseline, palmitate uptake across the arm was similar in the two groups, whereas leg palmitate uptake was lower than in the arm in the diabetic patients. During the clamp, palmitate uptake decreased in the arm (−48%, p=0.02) and the leg (−38%, p=0.04) of the control subjects, whereas it decreased in the arm (−30%, p=0.04) but not in the leg of the diabetic patients. Similarly, during the clamp palmitate release was substantially suppressed in the arm (−47%, p<0.01) and the leg of the control subjects (−45%, p<0.01), but only in the arm of the diabetic patients (−45%, p<0.01). Conclusions/interpretation: The present data indicate that type 2 diabetes is characterised by heterogeneity in the dysregulation of skeletal muscle fatty acid metabolism, with only the leg, but not the arm, showing an impairment of fatty acid kinetics at baseline and during a hyperinsulinaemic-euglycaemic clamp causing a physiological increase in insulin concentration.

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Section: Insulin Concentration and Plasma Palmitate Enrichmentmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Analytical Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heterogeneity in limb fatty acid kinetics in type 2 diabetes

et al. 2005

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The Association Between Physical Activity and the Risk of Incident Psoriasis

Frankel¹,

Han²,

Li³

et al. 2012

Arch Dermatol

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Increased Mortality Risk in Women With Depression and Diabetes Mellitus

Pan¹,

Lucas²,

Sun³

et al. 2011

Arch Gen Psychiatry

155

105

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Context Both depression and diabetes have been associated with an increased risk of all-cause and cardiovascular diseases (CVD) mortality. However, data evaluating the joint effects of these two conditions on mortality are sparse. Objectives To evaluate the individual and joint effects of depression and diabetes on all-cause and CVD mortality in a prospective cohort study. Design, Settings and Participants A total of 78282 female participants in the Nurses' Health Study aged 54-79 years at baseline in 2000 were followed until 2006. Depression was defined as having self-reported diagnosed depression, treatment with antidepressant medications, or a score indicating severe depressive symptomatology, i.e., a five-item Mental Health Index score ≤52. Self-reported type 2 diabetes was confirmed using a supplementary questionnaire. Main outcome measures All-cause and CVD-specific mortality. Results During 6 years of follow-up (433066 person-years), 4654 deaths were documented, including 979 deaths from CVD. Compared to participants without either condition, the age-adjusted relative risks (95% confidence interval, CI) for all-cause mortality were 1.76 (1.64-1.89) for women with depression only, 1.71 (1.54-1.89) for individuals with diabetes only, and 3.11 (2.70-3.58) for those with both conditions. The corresponding age-adjusted relative risks of CVD mortality were 1.81 (1.54-2.13), 2.67 (2.20-3.23), and 5.38 (4.19-6.91), respectively. These associations were attenuated after multivariate adjustment for other demographic variables, body mass index, smoking status, alcohol intake, physical activity, and major comorbidities (including hypertension, hypercholesterolemia, heart diseases, stroke and cancer) but remained significant, with the highest relative risks for all-cause and CVD mortality found in those with both conditions (2.07 [95% CI, 1.79-2.40] and 2.72 [95% CI, 2.09-3.54], respectively). Furthermore, the combination of depression with a long duration of diabetes (i.e., >10 years) or insulin therapy was associated with particularly higher risk of CVD mortality after multivariate adjustment (relative risk=3.22 and 4.90, respectively). Conclusions Depression and diabetes are associated with significantly increased risk of all-cause and CVD mortality. The coexistence of both conditions identifies particularly high-risk women.

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Physical activity and incidence of non-insulin-dependent diabetes mellitus in women

Cited by 1,049 publications

References 24 publications

Heterogeneity in limb fatty acid kinetics in type 2 diabetes

Heterogeneity in limb fatty acid kinetics in type 2 diabetes

The Association Between Physical Activity and the Risk of Incident Psoriasis

Increased Mortality Risk in Women With Depression and Diabetes Mellitus

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