Physical activity and energy expenditure in rheumatoid arthritis patients and matched controls

Henchoz, Yves; Bastardot, François; Guessous, Idris; Théler, Jean-Marc; Dudler, Jean; Vollenweider, Péter; So, Alexander

doi:10.1093/rheumatology/kes067

Cited by 49 publications

(33 citation statements)

References 43 publications

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“…However, when controlled for potential explanatory variables, only reduced activity due to fatigue, physical fatigue and disease activity were found to be statistically significantly lower in patients being regularly physically active. Findings from this study support previous studies documenting low levels of physical activity and increased sitting time in patients with RA compared to controls [9,[28][29][30]. Although no direct comparison was made in the present study, we found that 27 % of the patients in our study reported being primarily sedentary compared to 16.4 % of the Danish general population [31].…”

Section: Discussionsupporting

confidence: 88%

Physical activity and the association with fatigue and sleep in Danish patients with rheumatoid arthritis

et al. 2015

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The aim of this study was to examine physical activity behavior in patients with rheumatoid arthritis and to identify potential correlates of regular physical activity including fatigue, sleep, pain, physical function and disease activity. A total of 443 patients were recruited from a rheumatology outpatient clinic and included in this cross-sectional study. Physical activity was assessed by a four-class questionnaire, in addition to the Physical Activity Scale. Other instruments included the Multidimensional Fatigue Inventory (MFI), the Pittsburgh Sleep Quality Index and the Health Assessment Questionnaire. Disease activity was obtained from a nationwide clinical database. Of the included patients, 80 % were female and mean age was 60 (range 21-88 years). Hereof, 22 % (n = 96) were regularly physically active, and 78 % (n = 349) were mainly sedentary or having a low level of physical activity. An inverse univariate association was found between moderate to vigorous physical activity, and fatigue (MFI mental, MFI activity, MFI physical and MFI general), sleep, diabetes, depression, pain, patient global assessment, HAQ and disease activity. The multivariate prediction model demonstrated that fatigue-related reduced activity and physical fatigue were selected in >95 % of the bootstrap samples with median odds ratio 0.89 (2.5-97.5 % quantiles: 0.78-1.00) and 0.91 (2.5-97.5 % quantiles: 0.81-0.97), respectively, while disease activity was selected in 82 % of the bootstrap samples with median odds ratio 0.90. Moderate to vigorous physical activity in patients with rheumatoid arthritis is associated with the absence of several RA-related factors with the most important correlates being reduced activity due to fatigue, physical fatigue and disease activity.

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Section: Discussionsupporting

confidence: 88%

Physical activity and the association with fatigue and sleep in Danish patients with rheumatoid arthritis

et al. 2015

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“…Previous studies in RA that measured PA (5,18,19,31,32,41,42) did not characterize or measure PA across different intensity categories, and data specifically for participation at light intensities is limited. To date, only 2 studies in RA have reported PA at light intensity, and neither investigated the effect of light-intensity PA on cardiovascular disease risk factors (40,43).…”

Section: Discussionmentioning

confidence: 99%

Association of Light‐Intensity Physical Activity With Lower Cardiovascular Disease Risk Burden in Rheumatoid Arthritis

Khoja

Almeida

Wasko

et al. 2016

Arthritis Care & Research

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Objective: To characterize physical activity (PA) in individuals with rheumatoid arthritis (RA) and determine the associations between PA participation in light to moderate intensities and cardiovascular risk factors, disability, and disease activity. Methods: Cross-sectional study using data from two RA cohorts. PA was measured using an accelerometry-based activity monitor, and characterized as minutes/day in sedentary (≤1 metabolic equivalent-MET), very light (1.1–1.9 METs), light (2–2.9 METs), and moderate activities (≥3 METs). Cardiovascular markers included body mass index, blood pressure, insulin resistance, and lipid profile. Disability and disease activity were measured with the Health Assessment Questionnaire (HAQ) and Disease Activity Score-28 (DAS-28), respectively. Associations between PA at each intensity and health-markers were assessed by multiple linear regression models adjusted by age, sex, and cohort. Results: Ninety-eight subjects (58 ± 9 years, 85% female) were included. Subjects spent 9.8 hours/day being sedentary, 3.5 hours/day in very light PA, 2.1 hours/day in light PA and 35 minutes/day in moderate PA. Only 17% were physically active (≥150 minutes/week of moderate PA in 10-minute bouts). Regression models showed that very light, light and moderate PA were inversely associated with most cardiovascular risk factors, the HAQ, and DAS-28 scores (R2Δrange: .04 to .52, p <.05). The associations between PA and cardiovascular markers were either equivalent or stronger at very light- and light-intensities as compared to moderate-intensity. Conclusions: Individuals with RA are mostly active at very light and light intensities. PA at these intensities associate favorably with cardiovascular markers, and lower disability and disease activity in RA.

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“…Disease severity, disease activity, and symptoms may also influence PA participation in some rheumatic conditions, 26 although these were not recorded in this study because of challenges in assessing disease severity and activity accurately in the diverse range of rheumatic diseases included.…”

Section: Discussionmentioning

confidence: 99%

Are Patients Meeting the Updated Physical Activity Guidelines? Physical Activity Participation, Recommendation, and Preferences Among Inner-City Adults With Rheumatic Diseases

Manning

Hurley²,

Scott

et al. 2012

Journal of Clinical Rheumatology

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Physical activity and energy expenditure in rheumatoid arthritis patients and matched controls

Cited by 49 publications

References 43 publications

Physical activity and the association with fatigue and sleep in Danish patients with rheumatoid arthritis

Physical activity and the association with fatigue and sleep in Danish patients with rheumatoid arthritis

Association of Light‐Intensity Physical Activity With Lower Cardiovascular Disease Risk Burden in Rheumatoid Arthritis

Are Patients Meeting the Updated Physical Activity Guidelines? Physical Activity Participation, Recommendation, and Preferences Among Inner-City Adults With Rheumatic Diseases

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