Physical Activity and Cognitive Function among Older Adults with Congestive Heart Failure Patients

Crush, Paul D. LoprinziElizabeth

doi:10.5455/jmp.20160504115736

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…The Digit Symbol Substitution Test (DSST) was used to assess cognitive function [14-16], which was administered to adults over 60 years of age. The DSST, a component of the Wechsler Adult Intelligence Test and a test of visuospatial and motor speed-of-processing, has a considerable executive function component and is frequently used as a sensitive measure of frontal lobe executive functions [17].…”

Section: Methodsmentioning

confidence: 99%

Physical Activity and Cognitive Function among Older Adults with an Elevated Gamma Gap

Frith¹,

Loprinzi²

2018

Med Princ Pract

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Objective: An elevated gamma gap is indicative of high serum concentrations of globulin proteins, some of which elicit acute inflammatory responses. An impaired cognitive function has been linked to central and peripheral inflammation, while exercise is associated with protective, anti-inflammatory benefits. In this study, we evaluated whether the gamma gap is associated with cognitive function among older adults and whether physical activity is favorably associated with cognitive function among those with an elevated gamma gap. Materials and Methods: Data from the 1999–2002 National Health and Nutrition Examination Survey (NHANES) were used to identify 2,352 older adults aged between 60 and 85 years. The gamma gap was evaluated by subtracting albumin from total protein, i.e., gamma gap = total protein (g/dL) – albumin (g/dL). Those at or above 3.1 g/dL (31.0 g/L) were considered to have an elevated gamma gap. The Digit Symbol Substitution Test (DSST) was used to assess cognitive function tasks of pairing and free recall among participants. Participants were asked open-ended questions about participation in leisure-time physical activity over the previous 30 days. Results: Those with an elevated gamma gap (DSST, 44.8) had a lower cognitive function score when compared to those without an elevated gamma gap (DSST, 50.1) (p < 0.001). After adjustments, and among those with an elevated gamma gap, those meeting the moderate-to-vigorous intensity physical activity (MVPA) guidelines (vs. not meeting them) had a DSST score of 6.42 units higher (β = 6.42, 95% CI 3.85–8.99, p < 0.001). Conclusion: In this national sample of older adults, the gamma gap was associated with cognitive function, and among those with an elevated gamma gap, meeting the physical activity guidelines was associated with a higher cognitive function. Relevant clinical implications are discussed, as the gamma gap may be predictive of the risk for early mortality and reduced quality of life. Experimental work is needed to investigate whether physical activity training programs are effective in reducing an elevated gamma gap and preserving optimal cognitive functioning among at-risk individuals.

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Section: Methodsmentioning

confidence: 99%

Physical Activity and Cognitive Function among Older Adults with an Elevated Gamma Gap

Frith¹,

Loprinzi²

2018

Med Princ Pract

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Association Between Physical Activity and Cognitive Function Among a National Sample of Adults With Diabetes

Frith

Loprinzi

2018

Cardiopulm Phys Ther J

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Purpose: The cardiometabolic consequences associated with diabetes increase the risk of cognitive dysfunction. Physical activity is favorably associated with diabetes incidence and executive function, but surprisingly, there is limited research evaluating the effects of physical activity on cognitive function among adults with diabetes, which was the purpose of this study. Methods: Data from the 1999 to 2002 National Health and Nutrition Examination Survey (NHANES) were used. A national sample of older adults with diabetes was evaluated (N = 503; 60–85 yrs). The digit symbol substitution test (DSST) was used to assess executive function, with physical activity assessed through a valid questionnaire. Results: In an unadjusted weighted multivariable linear regression model, those meeting moderate-to-vigorous physical activity (MVPA) guidelines (vs not) had a DSST score 5.7 units higher (β = 5.7; 95% CI [1.46, 9.95]; P = .01). After adjusting for age, sex, race-ethnicity, smoking status, energy intake, weight status, and hypertension, those meeting MVPA guidelines (vs not) had a DSST score 3.8 units higher (β = 3.8; 95% CI [0.25, 7.32]; P = .03). Discussion: Physical activity is favorably associated with executive function among older adults with diabetes, but this association was attenuated after controlling for physical function and chronic illness.

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Physical Activity and Cognitive Function among Older Adults with Congestive Heart Failure Patients

Cited by 2 publications

References 20 publications

Physical Activity and Cognitive Function among Older Adults with an Elevated Gamma Gap

Physical Activity and Cognitive Function among Older Adults with an Elevated Gamma Gap

Association Between Physical Activity and Cognitive Function Among a National Sample of Adults With Diabetes

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