Physical activity and childhood cancer

Winter, Corinna; Müller, Carsten; Hoffmann, Christiane; Boos, Joachim; Rosenbaum, Dieter

doi:10.1002/pbc.22271

Cited by 83 publications

(111 citation statements)

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“…In addition, relevant child-specific outcomes and appropriate assessments must be determined to evaluate the holistic effects of therapeutic exercise specifically on childhood cancer patients. Consequently, as presented in other reviews, the current literature not only provides promising results but also reveals challenges to be faced in the future (3,12,13,15,16).…”

Section: Review Baumann Et Almentioning

confidence: 89%

“…However, there is still a lack of comprehensive and evidence-based data in the field of exercise interventions in pediatric oncology. Therefore, evidence-based exercise recommendations for childhood cancer patients are still missing (15,16).By contrast, systematic reviews in adult oncology have already been available for some years (17) and have even focused on specific entities such as prostate cancer (18). In pediatric oncology, three reviews (3,15,16) provided an overview of current research with promising results, but to our knowledge, no systematic review on exercise interventions including evidence levels has yet been published.…”

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confidence: 99%

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confidence: 99%

“…In pediatric oncology, three reviews (3,15,16) provided an overview of current research with promising results, but to our knowledge, no systematic review on exercise interventions including evidence levels has yet been published. However, this information would be important to establish evidencebased exercise recommendations particularly for childhood cancer patients.…”

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Clinical exercise interventions in pediatric oncology: a systematic review

2013

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Studies in pediatric oncology have shown a positive effect of physical activity on disease-and treatment-related side effects. Although several reviews have approved the benefits of therapeutic exercise for adult cancer patients, no systematic review exists summarizing the evidence of physical activity in pediatric oncology. We identified a total of 17 studies using the PubMed database and Cochrane library. To evaluate the evidence, we used the evaluation system of the Oxford Center for Evidence-Based Medicine 2001. The findings confirm that clinical exercise interventions are feasible and safe, especially with acute lymphoblastic leukemia (ALL) patients and during medical treatment. No adverse effects have been reported. Positive effects were found on fatigue, strength, and quality of life. Single studies present positive effects on the immune system, body composition, sleep, activity levels, and various aspects of physical functioning. Child-specific aspects such as cognitive abilities, growth, adolescence, and reintegration into peer-groups, school, and sports have barely been taken into consideration. The evidence for exercise interventions in pediatric oncology is rated level "3. " Although the results are very promising, future research of high methodological quality and focusing on child-specific aspects is needed to establish evidence-based exercise recommendations, particularly for childhood cancer patients.A s a result of improved treatment regimes in pediatric oncology, the survival rates of children with cancer have risen to ~80% for 5-y survival (1-4). Therefore, the population of childhood cancer survivors is constantly growing. Despite these positive developments, childhood cancer is associated with a wide spectrum of various disease-and treatment-related side effects that may develop into chronic diseases and therefore result in long-term consequences. A negative impact on social, psychological, and physiological levels can be observed. Inactivity (5-7), impaired cardiopulmonary and musculoskeletal function, as well as reduced motor performance levels (8,9) and cognitive abilities (10) have been detected. Current studies also examined a negative impact on psychological well-being, satisfaction, and social functioning (11). Taken together, an impaired quality of life can thus be determined (8,12).During the past few years, several studies have generated first hints describing holistic, positive effects of clinical exercise interventions in pediatric oncology. First results present an association between increased physical activity levels in childhood cancer patients and an improvement in quality of life (13). In particular, physical functioning is increased, anxiety is reduced, and social integration is encouraged (14). Considering the fact that physical activity plays a vital role in the physiological and psychosocial development of children, therapeutic exercise in pediatric oncology is particularly important. However, there is still a lack of comprehensive and evidence-based data in the field o...

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Section: Review Baumann Et Almentioning

confidence: 89%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Clinical exercise interventions in pediatric oncology: a systematic review

2013

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“…3 In addition, they typically have post-treatment physical impairments, particularly reduced motor performance 4 and reduced physical function, as measured with the 6-minute walk test (6MWT). [5][6][7][8] PA is essential for children to facilitate normal growth and development and particularly to promote general health and disease prevention, 9 as well as motor 10 and psychosocial 11 development.…”

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confidence: 99%

Associating Physical Activity Levels with Motor Performance and Physical Function in Childhood Survivors of Acute Lymphoblastic Leukemia

Hung

Rankin

Virji‐Babul

et al. 2017

Physiotherapy Canada

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Purpose: This cross-sectional, observational study investigated whether physical activity (PA) levels are associated with motor performance and physical function in children after treatment for acute lymphoblastic leukemia (ALL). Method: Participants aged 8-13 years who had completed treatment for ALL (3-36 months post-treatment) were tested at their oncology long-term follow-up appointment at the British Columbia Children's Hospital. PA level was measured using the Physical Activity Questionnaire for Older Children (PAQ-C). Motor performance was measured using the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition, Short Form (BOT-2 SF), and physical function was measured using the 6-minute walk test (6MWT). Results: Thirteen children completed testing. PAQ-C scores were not associated with BOT-2 SF or 6MWT performance. Eleven children (85%) performed below the norm for the 6MWT. Children with elevated body mass index had poorer 6MWT but similar PAQ-C scores. Conclusion: PA was not found to be associated with motor performance and physical function. Participants who were overweight or obese had poorer 6MWT performance, which may indicate the need for closer monitoring of post-treatment weight status and physical function in the oncology follow-up setting.Key Words: acute lymphoblastic leukemia; body mass index; motor skills; physical activity; physical fitness. RÉ SUMÉObjectif : cette é tude observationnelle à mé thodologie transversale portait sur le lien potentiel entre le niveau d'activité physique (AP) et la capacité motrice et physique des enfants ayant reç u un traitement contre la leucé mie lymphoblastique aiguë (LLA). Mé thode : des participants â gé s de 8 à 13 ans ayant reç u un traitement contre la LLA (de 3 à 36 mois aprè s le traitement) ont é té é valué s lors de leur rendez-vous de suivi à long terme en oncologie au British Columbia Children's Hospital. Le niveau d'AP a é té mesuré à l'aide du Questionnaire de mesure de l'activité physique chez les enfants (PAQ-C). La capacité motrice a é té mesuré e à l'aide du Bruininks-Oseretsky Test of Motor Proficiency, Deuxiè me é dition, Formulaire court (BOT-2 SF) et la capacité physique a é té mesuré e à l'aide du test de marche de 6 minutes (6MWT). Ré sultats : treize enfants ont effectué les tests. Aucun lien n'a é té observé entre les scores du PAQ-C et les ré sultats du BOT-2 SF ni ceux du 6MWT. Onze enfants (85 %) ont obtenu un ré sultat infé rieur à la norme au 6MWT. Les enfants ayant un indice de masse corporelle é levé ont obtenu des ré sultats plus faibles au 6MWT, mais des ré sultats similaires au PAQ-C. Conclusion : le niveau d'AP ne semble pas avoir de lien avec la capacité motrice ou physique. Les participants en surpoids et obè ses ont obtenu des ré sultats plus faibles au 6MWT, ce qui peut indiquer un besoin de surveillance plus é troit du poids et de la capacité physique aprè s le traitement lors des rendez-vous de suivi en oncologie.Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy in Canada, a...

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Efficacy of Mobile Instant Messaging–Delivered Brief Motivational Interviewing for Parents to Promote Physical Activity in Pediatric Cancer Survivors

Cheung

Chan

et al. 2022

JAMA Netw Open

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Key Points Question Can brief motivational interviewing delivered via mobile instant messaging promote regular physical activity in children who have survived cancer? Findings In this randomized clinical trial involving 161 children who survived cancer and their caregivers, brief motivational interviewing delivered via instant messaging significantly increased physical activity levels, reduced cancer-related fatigue, and improved handgrip strength and quality of life during a 12-month study period. Moderate to vigorous physical activity levels in intervention participants increased by 72.8%, compared with 6.3% in controls. Meaning The intervention used in this randomized clinical trial was effective in promoting regular physical activity in children who survived cancer; further investigation is warranted to enhance long-term sustainability of the intervention effect.

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Physical activity and childhood cancer

Cited by 83 publications

References 50 publications

Clinical exercise interventions in pediatric oncology: a systematic review

Clinical exercise interventions in pediatric oncology: a systematic review

Associating Physical Activity Levels with Motor Performance and Physical Function in Childhood Survivors of Acute Lymphoblastic Leukemia

Efficacy of Mobile Instant Messaging–Delivered Brief Motivational Interviewing for Parents to Promote Physical Activity in Pediatric Cancer Survivors

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