Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases

Rezende, Leandro F. M.; Sá, Thiago Hérick de; Markozannes, Georgios; Rey-López, Juan Pablo; Lee, I-Min; Tsilidis, Konstantinos K.; Ioannidis, John P. A.; Eluf‐Neto, José

doi:10.1136/bjsports-2017-098391

Cited by 195 publications

(138 citation statements)

References 46 publications

(24 reference statements)

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“…[37][38][39][40] In our study, one of the most investigated (7 systematic reviews) types of exercise was strength training. [37][38][39][40] In our study, one of the most investigated (7 systematic reviews) types of exercise was strength training.…”

Section: Strength Exercisesmentioning

confidence: 86%

Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses

2019

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Haemophilia is a genetic X-linked congenital haemorrhagic disorder characterized by a deficiency in the production of coagulation factors VIII and IX corresponding to haemophilia types A and B, respectively. 1,2 Although rare, with a frequency of 1 in 10 000 births, haemophilia can be found in about 400 000 people worldwide. 3 Approximately 85% of haemorrhagic episodes occur in the musculoskeletal system, hemarthroses and intramuscular haematomas, resulting in the main complications of haemophilia: pain, muscle atrophy and functional limitations that, in the long term, directly affect the performance of activities of daily living. 4,5 As a result, people with haemophilia (PWH) experience a more sedentary lifestyle, with lower muscle strength, aerobic and anaerobic endurance, and proprioception compared with healthy individuals. 6,7 A few decades ago, exercise was contraindicated for PWH due to low clotting factor concentrations and the high risk of bleeding.However, with the advent of concentrates for coagulation factor replacement as a form of treatment and prophylaxis to haemorrhages, Abstract Introduction: There is considerable evidence to indicate that exercise can have a positive impact on the treatment of people with haemophilia (PWH). However, there is a requirement for in-depth and comprehensive studies.Aim: This study aimed to analyse the evidence regarding the effects of exercise in PWH through an umbrella review of existing systematic reviews and meta-analyses.The secondary objective was to analyse the quality of the evidence.Methods: This umbrella review followed the PRISMA guidelines and was documented in the PROSPERO registry (CRD42019140785). We searched the PubMed, Web of Science, SPORTDiscus, Scopus, CINAHL and Cochrane Library databases.The methodological quality of the systematic reviews was assessed using AMSTAR 2.Results: Out of a total of 1030 systematic reviews, 10 fulfilled the criteria. Only one study was classified as high quality, and half of the selected studies were classified as low or critically low quality according to AMSTAR 2. Furthermore, most reviews investigated the effects of strength training and aquatic training, with positive results associated with low adverse events. Range of motion, strength and pain were the most investigated variables. All reviews showed overlapping studies. Conclusion:Exercise is an effective way to treat haemophilia and has a low incidence of related adverse events. However, caution is needed in the interpretation of the results due to half of the selected reviews showed low or critically low quality and only one have high quality. K E Y W O R D Sbleeding disorders, evidence-based practice, exercise, haemophilia, haemophilic arthropathy | 929 SIQUEIRA Et Al.

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Section: Strength Exercisesmentioning

confidence: 86%

Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses

2019

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“…Several meta-analyses and epidemiological studies seem to support this assumption [14,18,19]. After the cancer diagnosis, physical inactivity is raised in cancer patients due to the effect of main treatments on functional capacities that could be increased by psychological components such as anxiety, depression and reduced self-esteem [20].…”

Section: Introductionmentioning

confidence: 98%

Role of physical activity in cancer survival and recurrence: A narrative review from relationship evidence to crucial research perspectives

Maury¹,

Sénesse²,

Ninot³

2018

J Sports Med Ther

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Purpose:The benefi ts of Physical Activity (PA) considered as a major supportive care in cancer patients, on survival, and recurrence risk is largely disseminated in public communication. However, these data must be taken with caution. The main objectives were to review the evidence and limits of studies reported regarding the post-diagnosis PA role on cancer survival and recurrence risk to secondly discuss of research perspectives on PA programs. Method:The narrative review included all published or ongoing studies in English during the last 20 years related to PA, survival and recurrence risk with a systematic search on main databases. Results and discussion:The current evidences regarding the PA role on survival and recurrence risk were only based on cohort studies, mainly in breast cancer. The major methodological limits identifi ed as the lack of PA change assessment, PA level assessed largely by self-reported methods and the signifi cant inter-but also intra-variability make the interpretation of data very. Beyond the use of rigorous RCT, the major issue is to develop adapted and personalized interventions to progressively increase PA level overtime in cancer survivors. Conclusion:Despite the lack of causal relationship between post-diagnosis PA, survival and recurrence risk, the review underlines several interesting research perspectives. The future PA interventions, using innovative tools and integrated to the "real-life" will argued for the potential antitumoral PA role growing in literature.

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“…Deciphering the role of physical activity on cancer prevention is of high interest . Currently, convincing evidence from epidemiological studies supports the association between physical activity and cancers of the colon and breast, and possibly endometrium . Recently, findings from a pooled data from 12 prospective cohort studies including 1.44 million participants suggested a protective effect of physical activity on 13 types of cancers .…”

Section: Introductionmentioning

confidence: 99%

Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response

Lee

Rezende

Eluf‐Neto

et al. 2019

Intl Journal of Cancer

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Several biological mechanisms linking physical activity with cancer have been proposed. However, the influence of specific components of physical activity (volume, type and intensity), and their interaction with adiposity and diet, on cancer‐related biomarkers remain unclear. We used cross‐sectional data on 7,219 men in the Health Professionals Follow‐up Study (1992–1994) with C‐reactive protein (CRP), interleukin‐6 (IL6), tumor necrosis factor alpha receptor 2 (TNFαR2), adiponectin, C‐peptide and triglycerides/high‐density lipoprotein cholesterol ratio (TG/HDL). Details on physical activity, diet and adiposity were assessed by questionnaires. We used multivariable‐adjusted linear regression analyses to estimate relative concentrations of biomarkers by physical activity. Total physical activity was favorably associated with all biomarkers in a fairly linear manner. Comparing the highest (63+ metabolic equivalent (MET)‐hr/week) to the lowest (0‐8.9 MET‐hr/week) physical activity groups, the percent relative difference in concentration of biomarkers was −31% for CRP, −22% for IL6, −8% for TNFαR2, +9% for adiponectin, −22% for C‐peptide, and −20% for TG/HDL. These differences were modestly attenuated after adjustment for adiposity. For the same total MET‐hours of physical activity, the association was stronger for men engaging in both aerobic and resistance exercises compared to those engaging in aerobic only. However, no difference was found between those engaging in vigorous activities (≥20% of total MET‐hours) compared to those who did smaller amount of vigorous activities. Physical activity showed similar associations for these biomarkers regardless of adiposity and dietary pattern. In conclusion, high physical activity, preferably aerobic plus resistance training, was associated with favorable cancer‐related biomarkers.

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Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases

Cited by 195 publications

References 46 publications

Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses

Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses

Role of physical activity in cancer survival and recurrence: A narrative review from relationship evidence to crucial research perspectives

Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response

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