Physical Activity and Blood Lead Concentration in Korea: Study Using the Korea National Health and Nutrition Examination Survey (2008–2013)

Rhie, Jeongbae; Lee, Hye-Eun

doi:10.3346/jkms.2016.31.6.852

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…In this way, an increase could be possible in toxic metals ingested [18]. Previous studies have reported a high probability of sportsmen presenting higher serum concentrations of Pb than sedentary individuals, because of pollution [31]. In relation to time effect, the ANOVA showed significant differences in Pb (p < 0.05), similar to those previously obtained [32].…”

Section: Discussionsupporting

confidence: 86%

Serum and urinary concentrations of arsenic, beryllium, cadmium and lead after an aerobic training period of six months in aerobic athletes and sedentary people

Muñoz

Grijota

Bartolomé

et al. 2020

Journal of the International Society of Sports Nutrition

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Aim: The aim of the present study was to evaluate the possible effect of a period of 6 months of aerobic physical training on serum and urinary concentrations of arsenic (As), beryllium (Be), cadmium (Cd) and lead (Pb), potentially toxic minerals. Methods: Twenty-four well-trained, long distance runners (AG), were recruited at the start of their training period. They had been performing training regularly for the previous 2 years, recording an average volume of 120 km per week of rigorous aerobic exercise aimed at high-level competitions (1500 and 5000 m race modalities). Twenty-six untrained, sedentary participants constituted the control group (CG). All participants had been living in the same geographic area for at least 2 years before the start of the survey. Serum and urine samples were obtained from each participant at the beginning and at the end of the 6 months of the training program. The values of each mineral were determined by inductively coupled plasma mass spectrometry (ICP-MS). Additionally, the daily intake of each mineral was evaluated at both moments in time. Results: The daily concentrations of trace elements in the diet were similar at the start and the end of the training period without differences between groups. In serum, significant differences between groups were observed in As, Cd and Pb (p < 0.05). Attending to time effects, a significant difference was obtained in Pb (p < 0.05). In urine, significant differences between groups were obtained in all minerals (p < 0.05). According to training period, significant differences were observed in As, Be and Pb (p < 0.05). Finally, the group x time interaction revealed significant differences in As and Be (p < 0.05). Conclusions: Aerobic training may constitute a possibly effective method for increasing the elimination of Cd and Pb potentially toxic minerals from the body, especially among highly trained individuals.

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Section: Discussionsupporting

confidence: 86%

Serum and urinary concentrations of arsenic, beryllium, cadmium and lead after an aerobic training period of six months in aerobic athletes and sedentary people

Muñoz

Grijota

Bartolomé

et al. 2020

Journal of the International Society of Sports Nutrition

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“…The significantly high blood level of Cd in females than in males was observed beginning in the 30s. Human exposure to Pb could be affected by individual outdoor physical activities in school-aged subjects and individual behaviors including smoking habits and occupation 2039. Blood Hg level in the general population could be affected by individual lifestyle aspects like smoking and alcoholic drinking, and by diet, especially seafood consumption.…”

Section: Discussionmentioning

confidence: 99%

“…Human exposure to Pb could be affected by individual outdoor physical activities in school-aged subjects and individual behaviors including smoking habits and occupation. 20 39 Blood Hg level in the general population could be affected by individual lifestyle aspects like smoking and alcoholic drinking, and by diet, especially seafood consumption. The latter could vary in Korea depending on whether a person lived near the coast or inland.…”

Section: Discussionmentioning

confidence: 99%

Lead, Mercury, and Cadmium Exposure in the Korean General Population

Eom

Lee

et al. 2018

J Korean Med Sci

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BackgroundLead (Pb), mercury (Hg), and cadmium (Cd) are well-known environmental pollutants. They are unnecessary in the biological processes of humans. This study was performed to estimate the representative background exposure levels to the metals by measuring concentrations in whole blood of the Korean general population.MethodsThis population-based cross-sectional study included 4,000 subjects (1,886 males and 2,114 females) 0–83 years of age in 2010 and 2011. Adult subjects (≥ 19 years of age) were collected by sex- and age-stratified probability method, and preschool- and school-aged subjects were recruited by a cluster sampling method. Written consent was provided prior to blood sampling. Pb and Cd blood concentrations were determined by a flameless atomic absorption spectrophotometry, and blood Hg was analyzed by a direct Hg analyzer.ResultsThe geometric mean, median and 95th percentile of blood Pb was 1.82 µg/dL, 1.83 µg/dL, and 3.78 µg/dL, respectively. The respective values were 2.92 µg/L, 2.87 µg/L, 9.12 µg/L for Hg, and 0.56 µg/L, 0.59 µg/L, 2.20 µg/L for Cd. Blood Pb and Hg were higher in males than in females, but no sex difference was observed, respectively, in subjects 0–4 years of age for Pb and in subjects less than 20 years for Hg. However, blood Cd was higher in females than in males and no sex difference was observed in subjects < 30 years of age.ConclusionThis study provides representative data of human exposure to Pb, Hg, and Cd covering whole age groups of the general population in Korea.

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“…Inter-individual variation in blood Pb level is affected by various lifestyle and behavioral factors (i.e., smoking, drinking, dietary intake, and physical activity), as well as exposure dose [ 7 , 9 , 12 – 14 ]. In addition, genetic differences related to Pb toxicokinetics and toxicodynamics influence the body burden and toxic effects of this metal [ 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

et al. 2017

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BackgroundLead (Pb) is a ubiquitous toxic metal present in the environment that poses adverse health effects to humans. Inter-individual variation in blood Pb levels is affected by various factors, including genetic makeup. However, limited data are available on the association between genetic variation and blood Pb levels. The purpose of this study was to identify the genetic markers associated with blood Pb levels in the Korean population.MethodsThe study subjects consisted of 1,483 healthy adults with no history of occupational exposure to Pb. We measured blood Pb levels and calculated probable daily intake of Pb according to dietary data collected using 24-hour recall. We conducted exome-wide association screening using Illumina Human Exome-12v1.2 platform (n = 500) and a replication analysis using VeraCode Goldengate assay (n = 1,483).ResultsAmong the 244,770 single nucleotide polymorphisms (SNPs) tested, 12 SNPs associated with blood Pb level were identified, with suggestive significance level (P < 1 × 10−4). In the Goldengate assay for replication, three SNPs (C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671) were associated with statistically suggestively significant differences in blood Pb levels. When stratified by drinking status, a potential association of C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671 with blood Pb level was observed only in drinkers. A marginally significant gene-environment interaction between ALDH2 rs671 and alcohol consumption was observed in relation to blood Pb levels. The effects of the three suggestively significant SNPs on blood Pb levels was dependent on daily calcium intake amounts.ConclusionsThis exome-wide association study indicated that C12orf51 rs11066280, MYL2 rs12229654, and ALDH2 rs671 polymorphisms are linked to blood Pb levels in the Korean population. Our results suggest that these three SNPs are involved in the determination of Pb levels in Koreans via the regulation of alcohol drinking behavior, and that their negative effects may be compensated by appropriate calcium intake.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0220-x) contains supplementary material, which is available to authorized users.

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Physical Activity and Blood Lead Concentration in Korea: Study Using the Korea National Health and Nutrition Examination Survey (2008–2013)

Cited by 5 publications

References 33 publications

Serum and urinary concentrations of arsenic, beryllium, cadmium and lead after an aerobic training period of six months in aerobic athletes and sedentary people

Serum and urinary concentrations of arsenic, beryllium, cadmium and lead after an aerobic training period of six months in aerobic athletes and sedentary people

Lead, Mercury, and Cadmium Exposure in the Korean General Population

Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

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