Physical activity and antibody persistence 6 months after the second dose of CoronaVac in immunocompromised patients

Abstract

This prospective cohort study within an open‐label, single‐arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698) aimed to investigate the association between physical activity and persistent anti‐SARS‐CoV‐2 antibodies 6 months after two‐dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients (n = 748). Persistent immunogenicity 6 months after the full‐course vaccination was assessed using seroconversion rates of total anti‐SARS‐CoV‐2 S1/S2 IgG, geometric mean titers of anti‐S1/S2 IgG (GMT), and frequency of positive neutralizing antibodies (NAb). Physical activity was assessed trough questionnaire. Adjusted point estimates from logistic regression models indicated that physically active patients had greater odds of seroconversion rates (OR: 1.5 [95%CI: 1.1 to 2.1]) and NAb positivity (OR: 1.5 [95%CI: 1.0 to 2.1]), and approximately 43% greater GMT (42.8% [95%CI: 11.9 to 82.2]) than inactive ones. In conclusion, among immunocompromised patients, being physically active was associated with an increment in antibody persistence through 6 months after a full‐course of an inactivated SARS‐CoV‐2 vaccine.

Association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case–control study

“…In an open-label, single-arm, phase IV vaccination trial using two doses of the inactivated CoronaVac in immunocompromised patients, being physically active (self-reported via questionnaire) was associated with enhanced antibody persistence through 6 months 29…”