Physical activity among HIV-positive patients receiving antiretroviral therapy in Hanoi and Nam Dinh, Vietnam: a cross-sectional study

Dang, Anh Kim; Nguyen, Long H.; Nguyen, Anh Q.; Tran, Bach Xuan; Tran, Tung Thanh; Latkin, Carl A.; Zhang, Melvyn; Ho, Roger

doi:10.1136/bmjopen-2017-020688

Cited by 27 publications

(47 citation statements)

References 60 publications

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“…In the current study, participants residing in urban areas had higher odds of low PA than those in rural areas. This nding is in line with the studies conducted in sub-Saharan Africa countries, Northern Tanzania and Vietnam [27,30,31]. In Ethiopia, people living in the rural area are more often involved in vigorous and moderate activities than urban people, because more manual labor and agricultural activities are found in the rural area than urban.…”

Section: Discussionsupporting

confidence: 88%

Physical activity level and associated factors among adult HIV patients in Ethiopia

Tegene¹,

Mengesha²,

Starre³

et al. 2021

Preprint

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Background: People living with HIV, who take Antiretroviral Therapy (ART), often enjoy long and healthy lives, but this therapy has well known metabolic adverse effects. Physical activity is found to be an important factor in improving these physiological parameters. This study aimed to determine physical activity level and associated factors among HIV patients in Ethiopia. Methods: An institutional based cross sectional study was conducted from May to June 2019. We selected a total of 422 adult HIV patients, attending antiretroviral therapy clinics in three selected hospitals in Southern Ethiopia. Data were collected at routine care consultations by nine trained nurses using a pre-tested structured questionnaire. The level of physical activity was measured by the international physical activity questionnaire (IPAQ). Result: The mean age of participants was 38.7±9.13 years. Of the participants, 68% were physically inactive, with a higher proportion of inactive women (74%) than men (61%) [(AOR=1.64, 95% CI: (1.07, 2.53)]. In addition, urban vs. rural residents [(AOR=2.57, 95% CI: (1.16, 5.72)] and patients who were on ART for ≥24 months [(AOR=1.1.88, 95% CI: (1.15, 3.08)] had higher odds of having a low physical activity level. Conclusion: Most people living with HIV and receiving ART have low physical activity levels. Especially female and urban living patients and those with longer treatment duration have low levels of physical activity. More insight is needed on the reasons for physical inactivity among HIV patients and physical activity programs for HIV patients in low-income countries need to be developed.

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Section: Discussionsupporting

confidence: 88%

Physical activity level and associated factors among adult HIV patients in Ethiopia

Tegene¹,

Mengesha²,

Starre³

et al. 2021

Preprint

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“…Although earlier study from Malawian adults on ART showed that lipid abnormalities were not significantly different between rural and urban patients on similar ART regimens [ 21 ], we found that living in urban areas is associated with lower plasma HDL-c levels. The observed alterations in the blood levels of HDL-c might be as a consequence of a less physically active life style in urban areas than those in rural settings perhaps due to more access to modern transportation systems and sedentary behaviours in the urban setting [ 24 , 25 ]. HDL-c is a lipoprotein of cardiovascular protection and, it can be suggested that low levels of HDL-c may be significant factor of cardiovascular risk in urban patients on ART.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of dyslipidaemia among HIV-infected patients receiving combination antiretroviral therapy in North Shewa, Ethiopia

et al. 2021

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Background Data on the burden of dyslipidaemia among people with HIV undergoing antiretroviral therapy (ART) in sub-Saharan Africa are limited and little is known about the factors contributing for poor lipid profiles. The aim of this study was to determine the prevalence of dyslipidaemia and factors associated with lipid levels among HIV-infected patients receiving first-line combination ART in North Shewa, Ethiopia. Methods A cross-sectional study was conducted between April and December 2018 among 392 HIV-infected adults receiving first-line ART for at least six months at the ART clinic of Mehal Meda Hospital in North Shewa, Ethiopia. Blood samples were collected for determination of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and CD4 counts. Logistic regression analysis was used to determine factors associated with lipid abnormalities. Results The prevalence of dyslipidaemia was 59.9% (95% CI 55.0–64.7%). High TC, high TG, low HDL-c, and high LDL-c were obtained in 47.3%, 30.9%, 19.4% and 29.6%, respectively. Fifty-four participants (13.8%) had high ratio of TC/HDL-c (TC/HDL-c ratio ≥ 5). Older age was independently associated with high TC (AOR = 2.51, 95% CI 1.64–3.84), high TG (AOR = 2.95, 95% CI 1.85–4.71), low HDL–c (AOR = 2.02, 95% CI 1.17–3.50), and high LDL–c (AOR = 3.37, 95% CI 2.08–5.47). Living in an urban area (AOR = 2.61, 95% CI 1.16–6.14) and smoking (AOR = 3.61, 95% CI 1.06–12.34) were associated with low HDL–c. Participants with longer duration of ART use were more likely to have high TG (AOR = 1.86, 95% CI: 1.13–3.07), low HDL–c (AOR = 3.47, 95% CI: 1.75–6.80), and high LDL–c (AOR = 2.20, 95% CI 1.30–3.71). High BMI was independently associated with higher TC (AOR = 2.43, 95% CI 1.19–4.97), high TG (AOR = 4.17, 95% CI 2.01–8.67) and high LDL–c (AOR = 6.53, 95% CI 3.05–13.98). Conclusions We found a high prevalence of dyslipidaemia among HIV-infected patients receiving first-line ART in North Shewa, Ethiopia. There is a need for monitoring of blood lipid levels in patients with HIV on long term first-line ART with a special attention to be focused on older age, urban residents, longer duration of ART use, high BMI and smokers.

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“…Some studies have proposed that T cell immunity involving CD4-positive T cells plays a role in defense against Strongyloides stercoralis [11, 12]. Hence, we hypothesized that the use of ART in HIV-infected patients protects against helminths such as S. stercoralis and that immune restoration after ART reduces the incidence and severity of parasitic diseases [13]. However, further follow-up was required to study the effect of ART on intestinal parasites in registered HIV carriers in Lao PDR.…”

Section: Introductionmentioning

confidence: 99%

Intestinal helminth infections in HIV-infected patients in Savannakhet after establishment of an HIV registration network in Lao People’s Democratic Republic

Kaneshiro

Sourinphoumy²,

Imaizumi

et al. 2019

Trop Med Health

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BackgroundIn Lao People’s Democratic Republic (PDR), which borders China, Vietnam, Cambodia, Thailand, and Myanmar, the number of HIV-infected patients has increased in recent years. HIV-infected patients diagnosed in Lao PDR are enrolled in a registration network and receive antiretroviral therapy (ART) covered by governmental financial support. Based on the registration network, we investigated intestinal helminth infections and coinfection with HTLV-1 in HIV-infected patients treated with an early intervention using ART in Lao PDR.MethodsThis cross-sectional study of all 252 HIV-infected patients at Savannakhet Provincial Hospital, located in the southern part of Lao PDR, was conducted between February and March 2018. Socioepidemiological information and clinical information were collected from a registration network database and by questionnaire administered to participants. Microscopic examination of intestinal helminth infections in stool samples and particle agglutination for anti-HTLV-1 antibody in plasma were performed.ResultsThe median age of all 252 participants was 39 years old (range, 18–59). Based on the registration network database, there were 156 (61.9%) HIV-infected patients with a CD4-positive cell count ≥ 200 cells/μL and 146 (57.9%) with an HIV viral load < 250 copies/mL. Among 212 stool samples, 75 (35.4%) were found to contain one or more intestinal helminth species, including Opisthorchis viverrini (16.5%), Strongyloides stercoralis (10.8%), hookworm (10.4%), and Taenia saginata (3.3%). This rate of intestinal helminth infections was lower than that of a previous report conducted before the establishment of the registration network for HIV-infected patients in Lao PDR. There was no significant association between intestinal helminth infections and a lower CD4-positive T cell count or higher HIV viral load. HIV-infected patients with anti-HTLV-1 antibody positivity were not found in this cohort.ConclusionThe registration network and an early intervention using ART may provide good medical care and improve the clinical course of HIV-infected patients in Lao PDR. However, the incidence of intestinal helminth infections remains high at 35.4%. The development of a specific medical care system for helminth infection for HIV-infected patients is necessary.

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Physical activity among HIV-positive patients receiving antiretroviral therapy in Hanoi and Nam Dinh, Vietnam: a cross-sectional study

Cited by 27 publications

References 60 publications

Physical activity level and associated factors among adult HIV patients in Ethiopia

Physical activity level and associated factors among adult HIV patients in Ethiopia

Prevalence of dyslipidaemia among HIV-infected patients receiving combination antiretroviral therapy in North Shewa, Ethiopia

Intestinal helminth infections in HIV-infected patients in Savannakhet after establishment of an HIV registration network in Lao People’s Democratic Republic

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