Physical Activity Among Adults With a Disability—United States, 2005

doi:10.1001/jama.299.11.1255

JAMA

2008

DOI: 10.1001/jama.299.11.1255

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Physical Activity Among Adults With a Disability—United States, 2005

Abstract: REFERENCES 1. Advisory Committee on Immunization Practices. Preventing pneumococcal disease among infants and young children. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2000;49(No. RR-9). 2. Whitney CG, Farley MM, Hadler J, et al. Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine.

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Cited by 17 publications

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Retinopathy in systemic lupus erythematosus: Relationship to disease activity

Klinkhoff

Beattie

Chalmers

1986

Arthritis & Rheumatism

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Forty-three patients taking chloroquine for systemic lupus erythematosus were followed by one ophthalmologist over a 5-year period. Visual field testing, color vision testing, and fluorescein angiography were performed. Retinopathy was detected in 7 patients (16%1, none of whom had hypertension or diabetes melitus. Retinal abnormalities included cotton-wool spots in 4 patients, microaneurysms in 3, and vascular tortuosity in 4. In 4 patients, these abnormalities were associated with retinal dysfunction, measured in terms of abnormal hue discrimination. In 6 of the 7 patients, the finding of retinopathy coincided with a flare of lupus activity. In 5 patients, retinopathy improved when the disease was controlled.Retinopathy is a well-known complication of systemic lupus erythematosus (SLE). Before the advent of steroids, retinopathy was reported in 50% of SLE cases (1,2), However, the incidence of retinopathy in a predominantly outpatient population with milder disease has been reported to be relatively small (3). Between 1978 and 1983, 43 SLE patients treated with chloroquine were referred to one ophthalmologist. This has permitted us to follow the course of SLE retinopathy in a selected population. It became our

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Retinopathy in systemic lupus erythematosus: Relationship to disease activity

Klinkhoff

Beattie

Chalmers

1986

Arthritis & Rheumatism

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Bone Density Loss Is Associated With Blood Cell Counts

Valderrábano

Lui

Lee

et al. 2016

Journal of Bone and Mineral Research

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Hematopoiesis depends on a supportive microenvironment. Preclinical studies in mice have demonstrated that osteoblasts influence the development of blood cells, particularly erythrocytes, B lymphocytes, and neutrophils. However, it is unknown whether osteoblast numbers or function impact blood cell counts in humans. We tested the hypothesis that men with low BMD or greater BMD loss have decreased circulating erythrocytes and lymphocytes and increased myeloid cells. We performed a cross-sectional analysis and prospective analysis in the Osteoporotic Fractures in Men (MrOS), a multi-site longitudinal cohort study. 2571 community-dwelling men (≥65 years) who were able to walk without assistance, did not have a hip replacement or fracture and had complete blood counts (CBCs) at the third study visit were analyzed. Multivariable (MV)-adjusted logistic regression estimated odds of white blood cell subtypes (highest and lowest quintile vs middle), and anemia (clinically defined) associated with BMD by DXA scan (at visit 3), annualized percent BMD change (baseline to visit 3), and high BMD loss (>0.5%/year, from baseline to visit 3) at the femoral neck (FN) and total hip (TH). MV adjusted models included age, BMI, cancer history, smoking status, alcohol intake, corticosteroid use, self-reported health, thiazide use and physical activity. At visit 3 greater TH BMD loss (per standard deviation) was associated with increased odds of anemia, high neutrophils, and low lymphocytes. Annualized BMD loss of >0.5% was associated with increased odds of anemia, high neutrophils, and low lymphocytes. Similar results were observed for FN BMD regarding anemia and lymphocytes. We concluded that community-dwelling older men with declining hip BMD over about 7 years had increased risks of anemia, lower lymphocyte count, and higher neutrophil count, consistent with pre-clinical studies. Bone health and hematopoiesis may have greater interdependency than previously recognized.

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The Chitranjan Ranawat Award

Franklin

Ayers

2008

Clinical Orthopaedics &Amp; Related Research

167

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Physical Activity Among Adults With a Disability—United States, 2005

Cited by 17 publications

References 5 publications

Retinopathy in systemic lupus erythematosus: Relationship to disease activity

Retinopathy in systemic lupus erythematosus: Relationship to disease activity

Bone Density Loss Is Associated With Blood Cell Counts

The Chitranjan Ranawat Award

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