Physical activation of innate immunity by spiky particles

Wang, Ji; Chen, Hui‐Jiuan; Tian, Huawei; Yu, Yang; Liu, Gui-Shi; He, Gen; Xiao, Shuai; Yang, Bo‐Ru; Yang, Chengduan; Liu, Fanmao; Tao, Jun; Wu, Minxian; Xie, Xi

doi:10.1038/s41565-018-0274-0

Cited by 168 publications

(180 citation statements)

References 49 publications

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“…t is now clear that man-made nanoscale objects are processed by the whole range of endogenous biological machinery, in part via their in situ biomolecular corona surface [1][2][3][4][5][6] . The idea that "biology sees nanoscale shape" and that certain shape features could also specifically regulate (or even target) given biological pathways is an intriguing but still emerging concept [7][8][9][10][11][12][13] . Various aspects of shape at different length scales have always been implicitly involved in nanoscience [14][15][16][17][18][19][20] ; nanostructures are never smooth and spherical (on an atomic or few-atom scale) by virtue of their synthetic or other origin, and also some highly non-spherical (for example rod-like) objects are quite well studied [21][22][23][24][25][26][27][28] .…”

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confidence: 99%

Classification and biological identity of complex nano shapes

et al. 2020

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Everywhere in our surroundings we increasingly come in contact with nanostructures that have distinctive complex shape features on a scale comparable to the particle itself. Such shape ensembles can be made by modern nano-synthetic methods and many industrial processes. With the ever growing universe of nanoscale shapes, names such as "nanoflowers" and "nanostars" no longer precisely describe or characterise the distinct nature of the particles. Here we capture and digitise particle shape information on the relevant size scale and create a condensed representation in which the essential shape features can be captured, recognized and correlated. We find the natural emergence of intrinsic shape groups as well-defined ensemble distributions and show how these may be analyzed and interpreted to reveal novel aspects of our nanoscale shape environment. We show how these ideas may be applied to the interaction between the nanoscale-shape and the living universe and provide a conceptual framework for the study of nanoscale shape biological recognition and identity.

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confidence: 99%

Classification and biological identity of complex nano shapes

et al. 2020

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“…However, the physical cues of the microbes that trigger the immune system are still unclear. Wang et al ( 2018b ) showed that TiO 2 nanoparticles decorated with nanospikes activated innate immunity by physical stimulation. During their phagocytosis by APCs, mechanical stress induced by the spiky particles disrupted the cell membrane resulting in K + efflux, which activated the inflammasome and subsequently stimulated innate immunity.…”

Section: Emerging Adjuvantsmentioning

confidence: 99%

Emerging Adjuvants for Cancer Immunotherapy

2020

Front. Chem.

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Cancer is a life-threatening disease, and immunotherapies have been developed as a novel, potent treatment for cancer. Adjuvants, used alone or in combination with other agents, play crucial roles in immune activation. This is necessary for cancer immunotherapy, particularly in the construction of therapeutic cancer vaccines. Adjuvants activate antigen-presenting cells and promote the presentation of antigen epitopes on major histocompatibility complex molecules, further enhancing adaptive immune responses, including cytotoxic T lymphocytes, to elicit cancer-cell death. However, the applications of adjuvants are limited by their poor efficacy or insufficient safety. In recent studies, researchers attempted to develop safe, efficacious adjuvants for cancer immunotherapy, and many compounds (including inorganic compounds, organic molecules, polymers, and colloids) have been identified and optimized as agonists of various pathways. In this review, we focus on the discovery and structural design of emerging adjuvants and discuss how these findings benefit healthcare.

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“…NPs have been used to deliver immunostimulatory agents, antigens, cytokines, chemokines, nucleotides, and toll-like receptor (TLR) agonists that target various immune cells (Fan and Moon, 2015 ; Da Silva et al, 2016 ). In other cases, NP design has been carefully modulated to help mount anti-tumor immune responses through their material compositions, geometries, or surface modifications (Moon et al, 2012 ; Wang J. et al, 2018 ).…”

Section: Nanomedicine Approaches In Immunotherapymentioning

confidence: 99%