Physical abuse during childhood predicts IL-2R levels in adult panic disorder patients

Quagliato, Laiana A.; Coelho, Danielle A.; Matos, Ursula M.A. de; Nardi, Antônio Egídio

doi:10.1016/j.jad.2021.09.022

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…The link between EDys and hypersexuality is dual. First of all, EDys seems to determine hypersexual behavior due to an uncontrolled and excessive involvement in sexual activities characterized by a persistent desire or unsuccessful efforts to stop, reduce, or control sexual behaviors, and by cognitive salience, mood regulation, withdrawal, and functional impairment [49]. The second link is, instead, characterized by the tendency of individuals to adopt hypersexuality in the attempt to cope with intense negative emotions, such as stress, dysphoric mood, or high anxiety [50], or to face adverse life events [51].…”

Section: Evidencementioning

confidence: 99%

Hypersexuality as a tip of the iceberg of a primary psychopathology: a joined position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) and of the Italian Society of Psychopathology (SOPSI)

Limoncin

Ciocca

Castellini

et al. 2022

J Endocrinol Invest

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In the last years, hypersexual behavior has been broadly scientifically studied. The interest in this topic, belonging to psycho-sexology and sexual medicine, has been due to its still unclear aetiology, nature, and its manifestation in relationship with several organic and psychopathological conditions. So, the specialist (the psychologist, psychiatrist, endocrinologist, neurologist) may encounter some difficulties in diagnosing and managing this symptom. The first main objective of this position statement, which has been developed in collaboration between the Italian Society of Andrology and Sexual Medicine (SIAMS) and the Italian Society of Psychopathology (SOPSI) is to give to the reader evidence about the necessity to consider hypersexuality as a symptom related to another underlying condition. Following this consideration, the second main objective is to give specific statements, for the biopsychosocial assessment and the diagnosis of hypersexual behavior, developed on the basis of the most recent literature evidence. To develop a psycho-pharmacological treatment tailored on patients' needs, our suggestion is to assess the presence of specific comorbid psychopathological and organic conditions, and the impact of pharmacological treatments on the presence of an excess of sexual behavior. Finally, a suggestion of a standardized psychometric evaluation of hypersexuality will be given.

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Section: Evidencementioning

confidence: 99%

Hypersexuality as a tip of the iceberg of a primary psychopathology: a joined position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) and of the Italian Society of Psychopathology (SOPSI)

Limoncin

Ciocca

Castellini

et al. 2022

J Endocrinol Invest

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“…In recent years, childhood maltreatment has aroused widespread concern in the social and scientific fields. In addition to being highly prevalent, it has also been confirmed as a powerful and important predictor of poor health outcomes in adulthood ( Copeland et al, 2018 ; Appelmann et al, 2021 ), such as borderline personality disorder ( Marchetti et al, 2021 ), posttraumatic stress disorder ( Bremner et al, 1997 ), major depression ( Medeiros et al, 2020 ), anxiety ( King, 2021 ), panic disorder ( Quagliato et al, 2021 ), and alcoholism ( Fenton et al, 2013 ). Much evidence indicates neurobiological mechanisms by which childhood maltreatment increases the vulnerability to psychopathology ( McCrory et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Genetic influence on brain volume alterations related to self-reported childhood abuse

Tian

et al. 2022

Front. Neurosci.

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As an important predictor of adulthood psychopathology, self-reported childhood abuse appears heritable and is associated with brain abnormalities. However, the specific genetic mechanisms behind these brain alterations remain largely unknown. This study recruited young adults who reported different degrees of childhood abuse from the community. In order to fully understand the influence of genes on brain changes related to self-reported childhood abuse, various experiments were conducted in this study. Firstly, volume changes of gray matter and white matter related to childhood abuse were investigated by using advanced magnetic resonance imaging techniques. After sequencing the whole exons, we further investigated the relationship between polygenic risk score, brain volume alterations, and childhood abuse score. Furthermore, transcription-neuroimaging association analysis was used to identify risk genes whose expressions were associated with brain volume alterations. The gray matter volumes of left caudate and superior parietal lobule, and white matter volumes of left cerebellum and right temporal lobe-basal ganglia region were significantly correlated with the childhood abuse score. More importantly, brain volume changes mediated the influence of polygenic risk on self-reported childhood abuse. Additionally, transcription-neuroimaging association analysis reported 63 risk genes whose expression levels were significantly associated with childhood abuse-related brain volume changes. These genes are involved in multiple biological processes, such as nerve development, synaptic transmission, and cell construction. Combining data from multiple perspectives, our work provides evidence of brain abnormalities associated with childhood abuse, and further indicates that polygene genetic risk and risk gene expression may affect the occurrence of childhood abuse by brain regulation, which provides insights into the molecularpathology and neuromechanism of childhood adversity. Paying attention to the physical and mental health of high-risk children may be a fundamental way to prevent childhood abuse and promote lifelong mental health.

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A cross-sectional healthy-control study of serum inflammatory biomarkers interleukin (IL)-1B and IL-2R in panic disorder patients and their offspring

Quagliato

Nardi

2022

Journal of Psychiatric Research

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Physical abuse during childhood predicts IL-2R levels in adult panic disorder patients

Cited by 5 publications

References 44 publications

Hypersexuality as a tip of the iceberg of a primary psychopathology: a joined position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) and of the Italian Society of Psychopathology (SOPSI)

Hypersexuality as a tip of the iceberg of a primary psychopathology: a joined position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) and of the Italian Society of Psychopathology (SOPSI)

Genetic influence on brain volume alterations related to self-reported childhood abuse

A cross-sectional healthy-control study of serum inflammatory biomarkers interleukin (IL)-1B and IL-2R in panic disorder patients and their offspring

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