Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes
Lu Liu,
Sen Sun,
Xiaohua Li
Abstract:Context
The effect of the active ingredients in traditional Chinese medicines on the activity of cytochrome P450 enzymes (CYP450s) is a critical factor that should be considered in TCM prescriptions. Physcion, the major active ingredient of
Rheum
spp. (Polygonaceae), possesses wide pharmacological activities.
Objectives
The effect of physcion on CYP450 activity was investigated to provide a theoretical basis for use.
Materials a… Show more
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