Physalis peruviana L. inhibits ovalbumin‑induced airway inflammation by attenuating the activation of NF‑κB and inflammatory molecules

Abstract

Physalis peruviana L. (PP) is well known for its various properties, including its antioxidant property. In our previous study, the protective effects of PP against cigarette smoke-induced airway inflammation were confirmed. The purpose of the present study was to evaluate the anti-inflammatory effect of PP against ovalbumin (OVA)-induced airway inflammation. Treatment with PP inhibited the numbers of eosinophils and the levels of inflammatory cytokines, including interleukin (IL)-4, IL-5 and IL-13, in the bronchoalveolar lavage fluid (BALF) of animal models with OVA-induced allergic asthma. PP also significantly decreased the production of total immunoglobulin E in the serum. Lung sections stained with hematoxylin and eosin revealed that the influx of inflammatory cells was decreased in the lungs of mice treated with PP compared with cells in the OVA group. The increased expression levels of monocyte chemoattractant protein-1 (MCP-1) and T cell marker KEN-5 were also reduced following PP treatment in the lung tissues compared with those in the OVA group. The PAS staining results showed that PP attenuated the overproduction of mucus in the lung. Additionally, western blot analysis revealed that PP significantly downregulated the activation of nuclear factor-κB/p38 mitogen-activated protein kinase/c-Jun N-terminal kinase, and upregulated the expression of heme oxgenase-1 in the lungs. In an in vitro experiment, PP effectively reduced the levels of LPS-stimulated MCP-1 in a concentration-dependent manner. Taken together, these results indicate that PP has considerable potential in the treatment of allergic asthma.

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

“…Healthy female BALB/c mice (n=30, 6 weeks old; body weight, 16-18 g) were purchased from Koatech Co., Ltd., and used after 1 week of acclimatization with free access to food and water in specific pathogen-free conditions (22-23°C; 55-60% humidity; 12-h light/dark cycle). The experimental procedure was performed according to the methods described by Park et al (21). Briefly, the mice were sensitized twice intraperitoneally on day 0 and 14 with 30 µ g OVA and 3 mg Alums (Thermo Fisher Scientific, Inc.) dissolved in a solution of 0.2 ml PBS.…”

Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma

“…Sun et al have demonstrated that metformin, which is used for the treatment of diabetes type 2, reduces lipopolysaccharide-induced damage to bronchial epithelial cells by suppressing NF-κB signaling [74]. The inhibition of the NF-κB signaling pathway is associated with the antiinflammatory effect of Physalis peruvianaL., used in the model of allergic asthma in animals [75]. It is apparent that the study of NF-κB functions is necessary to search for new therapeutic approaches in asthma.…”

Lagerstroemia ovalifolia Exerts Anti- Inflammatory Effects in Mice of LPSInduced ALI via Downregulating of MAPK and NF-κB Activation

“…Plant extracts have been shown to exert protective effects against acute or chronic inflammatory lung diseases [ 16 - 18 ]. Lagerstroemia ovalifolia Teijsm.…”