Physalis alkekengi L. Extract Reduces the Oxidative Stress, Inflammation and Apoptosis in Endothelial Vascular Cells Exposed to Hyperglycemia

Vicaş, Laura; Jurca, Tünde; Bâldea, Ioana; Filip, Gabriela Adriana; Olteanu, Diana; Clichici, Simona; Pallag, Annamária; Marian, Eleonora; Micle, Otilia; Crivii, Carmen; Suciu, Tudor; Craciun, Izabela; Gligor, Felicia Gabriela; Mureşan, Mariana

doi:10.3390/molecules25163747

Cited by 16 publications

(5 citation statements)

References 72 publications

(89 reference statements)

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“…The finding was in agreement with antioxidant activity measured for Physalis alkekengi fruit extract by Vicas et [30,31].…”

Section: Antioxidant Activity Evaluated By Spectrophotometric Assayssupporting

confidence: 93%

Metabolite Profiling, through LC-ESI/LTQOrbitrap/MS Analysis, of Antioxidant Extracts from Physalis alkekengi L.

Crescenzi,

Serreli,

Deiana

et al. 2023

Antioxidants

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Due to the increasing use of Physalis alkekengi L. as a food supplement and starting material for tea preparation, a comprehensive analysis of green extracts was performed. Two different extraction methods were applied to yellow Physalis alkekengi L. fruit and calyx and compared: hydroalcoholic extraction and decoction. Characterization of the metabolome of the calyx and fruit of yellow Physalis alkekengi L. was performed by LC-ESI/LTQOrbitrap/MS followed by LC-ESI/LTQOrbitrap/MS/MS to identify 58 phytocompounds using the two different extraction techniques. Subsequently, through preliminary spectrophotometric assays followed by cell studies, the antioxidant activity of the different Physalis alkekengi L. extracts were evaluated. It was found that Physalis alkekengi L. extracts are a good source of metabolites such as flavonoids, organic acids, phenylpropanoids, physalins and carotenoids, with various biological activities, in particular, antioxidant activity capable of reducing the production of free radicals in intestinal Caco-2 cells. For the first time, an integrated approach (metabolomics approach and antioxidant evaluation) was applied to the study of Physalis alkekengi green extracts and decoctions, the green extraction method mostly used in herbal preparations. An interesting finding was the high antioxidant activity shown by these extracts.

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“…The finding was in agreement with antioxidant activity measured for Physalis alkekengi fruit extract by Vicas et [30,31].…”

Section: Antioxidant Activity Evaluated By Spectrophotometric Assayssupporting

confidence: 93%

Metabolite Profiling, through LC-ESI/LTQOrbitrap/MS Analysis, of Antioxidant Extracts from Physalis alkekengi L.

Crescenzi,

Serreli,

Deiana

et al. 2023

Antioxidants

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“…Hematoma compression can lead to hypothalamus-pituitary-adrenal axis injury and reduce the biological uptake and utilization of glucose in peripheral tissues [ 13 , 14 ]. In contrast, hyperglycemic state can affect brain tissue energy metabolism, leading to acidosis due to lactic acid accumulation and can induce oxidative stress, which aggravates neuronal cell damage and is detrimental to the prognosis of patients with cerebral hemorrhage [ 15 , 16 ]. Therefore, clinical attention has been paid to the treatment of stress hyperglycemia in neurosurgical patients.…”

Section: Discussionmentioning

confidence: 99%

Influence of Optimal Management of Hyperglycemia and Intensive Nursing on Blood Glucose Control Level and Complications in Patients with Postoperative Cerebral Hemorrhage

Sun

2022

Computational and Mathematical Methods in Medicine

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Background. Cerebral hemorrhage, also known as hemorrhagic stroke, is a common clinical cerebrovascular disease, accounting for about 10%-30% of stroke, with high morbidity and mortality. Objective. To observe the effect of optimal management of hyperglycemia and intensive nursing on blood glucose control level and complications in patients with postoperative cerebral hemorrhage. Methods. One hundred and eight patients with postoperative cerebral hemorrhage comorbid with stress hyperglycemia admitted to our neurosurgery department from February 2019 to February 2022 were selected and divided into a general group of 54 cases and an optimized group of 54 cases by simple random method. The general group was managed with conventional care, while the optimized group developed optimized management of hyperglycemia for intensive care. The indexes related to blood glucose control, electrolytes, National Institutes of Health Stroke Scale (NIHSS) scores, Barthel Index (BI) scores, and time to achieve blood glucose standard, insulin pumping time, patient satisfaction, and prognosis were compared between the two groups. Results. Before intervention, there was no statistical significance in the comparison of blood glucose control-related indicators and electrolytes between the two groups ( P > 0.05 ). After 7 d and 14 d of intervention, the fasting blood glucose and 2 h postprandial blood glucose in the two groups were lower than before, while K+ and Na+ were higher than before ( P < 0.05 ). The blood glucose indexes at the same time point in the optimized group were found to be lower than those in the general group by statistical analysis, but electrolytes were not statistically significant when compared with the general group ( P > 0.05 ). In the optimized group, the time to achieve blood glucose standard ( 6.59 ± 1.94 ) d and insulin pumping time ( 7.14 ± 1.89 ) d were shorter than those in the general group [( 7.48 ± 2.12 ) d and ( 8.58 ± 2.14 ) d], insulin dosage ( 748.85 ± 63.61 ) U was less than that in the general group ( 923.54 ± 84.14 ) U, and the incidence of hypoglycemia (3.70%) was lower than that in the general group (16.67%), and the satisfaction rate (92.59%) was higher than that of the general group (77.78%), which was statistically significant ( P < 0.05 ). Before intervention, there was no significant difference in NIHSS score and BI score between the two groups ( P > 0.05 ). After 7 d and 14 d of intervention, the NIHSS scores of the two groups were lower than before, while the BI scores were higher than before, and the NIHSS scores of the optimized group at the same time point were all lower than those of the general group, and the BI scores were higher than those of the general group ( P < 0.05 ). The incidence of pulmonary infection (11.11%) and rebleeding (7.41%) in the optimized group were lower than those in the general group (25.93% and 22.22%), while deep vein thrombosis, multiple organ dysfunction syndrome (MODS), and death within 28 d was not statistically significant when compared with the general group ( P > 0.05 ). Conclusion. Optimal management of hyperglycemia and intensive nursing can effectively control the blood sugar level of patients after cerebral hemorrhage, reducing insulin dosage, and the occurrence of hypoglycemia, pulmonary infection, and rebleeding.

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“…For example, resveratrol is able to increase Gly-LDLinduced vascular endothelial cell apoptosis (29). Similarly, Physalis alkekengi L. extract can reduce the apoptosis of ECs after exposing to hyperglycemia (30). Overall, angiogenic factors secreted by tumor cells (Figure 1) and EC apoptosis (Figure 2) are of significance in triggering and processing vessel formation in tumor microenvironment.…”

Section: Activated Factors and Ecs Apoptosis In Tumor Angiogenesismentioning

confidence: 97%

Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis

Song

Guo

et al. 2021

Front. Oncol.

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Tumor-associated angiogenesis is a key target for anti-cancer therapy. The imbalance between pro-angiogenic and anti-angiogenic signals elicited by tumor cells or tumor microenvironment always results in activating “angiogenic switch”. Tumor angiogenesis functions in multi-aspects of tumor biology, including endothelial cell apoptosis, tumor metastasis, and cancer stem cell proliferation. Numerous studies have indicated the important roles of inexpensive and less toxic natural products in targeting tumor angiogenesis-associated cytokines and apoptotic signaling pathways. Our current knowledge of tumor angiogenesis is based mainly on experiments performed on cells and animals, so we summarized the well-established models for angiogenesis both in vitro and in vivo. In this review, we classified and summarized the anti-angiogenic natural agents (Polyphenols, Polysaccharides, Alkaloids, Terpenoids, Saponins) in targeting various tumor types according to their chemical structures at present, and discussed the mechanistic principles of these natural products on regulating angiogenesis-associated cytokines and apoptotic signaling pathways. This review is to help understanding the recent progress of natural product research for drug development on anti-tumor angiogenesis.

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Physalis alkekengi L. Extract Reduces the Oxidative Stress, Inflammation and Apoptosis in Endothelial Vascular Cells Exposed to Hyperglycemia

Cited by 16 publications

References 72 publications

Metabolite Profiling, through LC-ESI/LTQOrbitrap/MS Analysis, of Antioxidant Extracts from Physalis alkekengi L.

Metabolite Profiling, through LC-ESI/LTQOrbitrap/MS Analysis, of Antioxidant Extracts from Physalis alkekengi L.

Influence of Optimal Management of Hyperglycemia and Intensive Nursing on Blood Glucose Control Level and Complications in Patients with Postoperative Cerebral Hemorrhage

Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis

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