Physaliphorous cells

Pandiar, Deepak; Thammaiah, Smitha

doi:10.4103/jomfp.jomfp_265_18

Cited by 8 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Pathognomonic physaliphorous (vacuolated appearance) cells within myxoid stroma are typically observed in the conventional subtype. 5 Our case belongs to the chondroid subtype, which is characterized by the presence of a chondroid differentiation area within the conventional chordoma tissue. 6 The findings of previous studies suggest no notable difference in survival rate between the conventional and chondroid subtypes.…”

Section: Discussionmentioning

confidence: 93%

An experience in treatment of neurologically silent clival chordoma mimicking a nasopharyngeal tumor

Lin

Hsu

2021

Ear Nose Throat J

View full text Add to dashboard Cite

Cranial chordoma is a rare neoplasm that is challenging to both diagnose and manage. We present our experience in treating a case of clival chordoma mimicking a nasopharyngeal mass without any signs of cranial deficits or intracranial insult. Management was comprised of endoscopic transnasal debulking surgery followed by radiotherapy. However, we failed to achieve an oncologic outcome due to the development of lethal central nervous system and respiratory infections 1 month after the surgery.

show abstract

Section: Discussionmentioning

confidence: 93%

An experience in treatment of neurologically silent clival chordoma mimicking a nasopharyngeal tumor

Lin

Hsu

2021

Ear Nose Throat J

View full text Add to dashboard Cite

show abstract

“…Upon further workup, pathology showed physaliphorous cells, which are pathognomonic of chordoma. 12 Interestingly a Korean study of 52 patients with chordomas found that there were histopathological differences depending on the site of chordoma, specifically clival/intradural chordomas tend to present more with diffuse growth pattern and chondroid matrix whereas spinal/sacral chordomas demonstrate lobulating pattern. 13 Clear cell carcinoma of the lung is an exceedingly rare diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…6 Physaliphorous cells are cells with vacuolated or bubbly appearance that correspond with the notochord consisting of chordocytes with prominent vacuoles. 12 An additional histologic feature that favored chordoma was the presence of abundant fibrillary myxoid stroma. Stroma within clear cell carcinoma would be unusual, but clear cell carcinoma has been reported to rarely contain benign smooth muscle stroma which is histologically distinct from the stroma seen in Figure 4.…”

Section: Discussionmentioning

confidence: 99%

A rare case of chordoma presenting as a Pancoast tumor

et al. 2021

View full text Add to dashboard Cite

The notochord is the defining structure of all chordate embryos. It is a midline structure ventral to the ectoderm, neural plates, and neural arch. Remnants of the notochord ultimately give rise to the nucleus pulposus. The function of the notochord is to organize the surrounding structures. Chordoma is a rare malignant bone tumor arising from remnants of the notochord. These tumors are indolent and can present as incidental or locally advanced involving adjacent structures. These tumors typically present at the skull base and sacral spine but more rarely can be seen on the cervical and thoracic spine. Rare cases of chordoma invading the brachial plexus have been recorded. Surgical resection is the mainstay of treatment for chordomas. We would like to discuss a novel presentation of a chordoma as a Pancoast tumor, and aim to highlight the clinical importance of accurate diagnosis and planning therapy along with poor prognosis of incomplete surgical resection.

show abstract

“…For reference to the histomorphology of human disc tissue, please consult the studies cited here (Boos et al, 2002;Rutges et al, 2013). Notochordal NP cells are large and vacuolated, often forming groups and clusters and described as a physaliforous cell type (Pandiar and Thammaiah, 2018). They are relatively quiescent with regards to proteoglycan metabolism, but have a marked influence on the metabolism of proteoglycans within the NP (Aguiar et al, 1999).…”

Section: Intervertebral Disc Structure and Comparative Anatomymentioning

confidence: 99%

Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology

Melrose¹,

Tessier²,

Risbud

2021

eCM

View full text Add to dashboard Cite

Disc degeneration and associated back and neck pain elicits a substantial burden on healthcare systems and the individuals affected, necessitating the development of novel therapeutic strategies. This goal can only be achieved by a better understanding of intervertebral disc development, homeostasis and pathogenesis. A number of genetic and in-bred murine models are reviewed to underscore the importance of the mouse as an animal model of choice for the assessment of intervertebral disc pathobiology. Appraisals of the differences between mouse and human musculoskeletal systems and proteoglycan structures are also included. A number of important target pathways and molecules have been identified, many of which are worthy of further examination, requiring that the activity of these be confirmed in large animal models and assessed in the context of therapeutic intervention.

show abstract

Physaliphorous cells

Cited by 8 publications

References 5 publications

An experience in treatment of neurologically silent clival chordoma mimicking a nasopharyngeal tumor

An experience in treatment of neurologically silent clival chordoma mimicking a nasopharyngeal tumor

A rare case of chordoma presenting as a Pancoast tumor

Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology

Contact Info

Product

Resources

About