Phyre 2 and I-Tasser web portal for Protein modeling, Prediction and Validation of gel Q and gel K genes from gellan gum producing bacterial strain <i>Sphingomonas paucimobilis</i> ATCC 31461

Manjusha, C. M.; Santhiagu, A.; Soumiya, S; Adarsh, V. K.; Prakash, S. Jaya

doi:10.5958/0974-360x.2019.00006.4

Cited by 3 publications

(1 citation statement)

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“…As a result, it served as a starting point for creating a 3D model of the human ZFP42 protein. Software packages like SWISS-MODEL [43], I-TESSAR [44], and Phyre2 (https://www.sbg.bio.ic.ac.uk/phyre2/html) [45] were used for protein modeling.…”

Section: Conservation Analyses Consurfmentioning

confidence: 99%

Positive Selection in Zinc Finger Protein Reveals Genetic Signatures of Adaptive Evolution in Undifferentiated Stem Cells during Evolution in Mammals

Ali¹,

Khan

Mahmood³

et al. 2023

Journal of Zoological Systematics and Evolutionary Research

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Positive selection refers to the process by which certain genetic variations are more likely to be passed on to future generations because they confer some advantage in terms of survival or reproduction. Zinc finger proteins are a type of transcription factor that plays a role in regulating gene expression, particularly in undifferentiated stem cells. Suppose it has been found that certain zinc finger proteins show genetic signatures of positive selection in mammals. In that case, it suggests that these proteins may have played a role in adaptive evolution in undifferentiated stem cells. This could mean that the specific genetic changes in these zinc finger proteins gave an advantage to the organisms that possessed them, helping them survive and reproduce more effectively. These genetic changes may have allowed the organisms to adapt to changing environments or to develop new abilities, such as increased resistance to disease or faster growth. Undifferentiated stem cells that underwent adaptive evolution during the evolution of mammals can be identified genetically by the outcomes of positive selection on zinc finger proteins. Because of selection pressures like environmental shifts or the introduction of novel pathogens, it is plausible that some zinc finger proteins have experienced fast evolution. The emergence of novel activities or higher expression levels of these proteins as a result of this quick evolution may have given the creatures that possessed them a survival edge. Another possible outcome of positive selection in zinc finger proteins is the emergence of new genetic variations that allow for increased diversity and plasticity in stem cells. This increased diversity and plasticity could have allowed for more efficient adaptation to changing environments and could have played a role in the evolution of new organisms or new characteristics in existing organisms. Overall, the results of positive selection in zinc finger proteins can provide insight into how adaptive evolution occurred in undifferentiated stem cells during the evolution of mammals and how this evolution may have contributed to the development of new organisms and new characteristics and adaptations to changing environments.

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Section: Conservation Analyses Consurfmentioning

confidence: 99%

Positive Selection in Zinc Finger Protein Reveals Genetic Signatures of Adaptive Evolution in Undifferentiated Stem Cells during Evolution in Mammals

Ali¹,

Khan

Mahmood³

et al. 2023

Journal of Zoological Systematics and Evolutionary Research

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Viral genomics

Mahmoud,

Khalil

2024

Microbial Genomics: Clinical, Pharmaceutical, and Industrial Applications

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An intelligent web-based point of sales management system for small and medium scale businesses

Mishack

Essiaw

Razak

et al. 2021

IJT

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The increase in population globally has caused organisations and businesses to move from square rooms, table-top and containers into supermarkets, malls and more. With this expansion in businesses, the traditional pen and paperwork system for keeping records are becoming more difficult for salespersons and shop owners everywhere. However, the introduction of the point-of-sales management system and advancement in technologies have elevated the challenges facing shop owners in managing their daily sales and balance sheet. Despite the overwhelming number of POS systems available, wholesalers and retailers' in low-income counties such as Ghana see some challenges with the existing POS, cost-effectiveness, and user-friendliness. Thus, the cultural difference makes it difficult for easy adaptation of shop owners to off-the-shell POS system. Hence, the current study sought to design and develop a user-friendly, low-cost intelligent web-based point of sales management system for small and medium scale business in the Bono region of Ghana, based on a user-centred approach. Using a waterfall model, we implement a POS system based on XAMP server and MySQL database as backend and PHP for server-side scripting. At the same time, HTML and CSS were used for front end development. Our experimental setup with ten students shows that the proposed system is easy to use and robust. Thus, it has a user-friendly interface for even novice to learn it with ease.

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Phyre 2 and I-Tasser web portal for Protein modeling, Prediction and Validation of gel Q and gel K genes from gellan gum producing bacterial strain Sphingomonas paucimobilis ATCC 31461

Cited by 3 publications

References 0 publications

Positive Selection in Zinc Finger Protein Reveals Genetic Signatures of Adaptive Evolution in Undifferentiated Stem Cells during Evolution in Mammals

Positive Selection in Zinc Finger Protein Reveals Genetic Signatures of Adaptive Evolution in Undifferentiated Stem Cells during Evolution in Mammals

Viral genomics

An intelligent web-based point of sales management system for small and medium scale businesses

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