Phylogeny of lymphocyte heterogeneity. IV. Evidence for T-like and B-like cells in reptiles

Cuchens, Marvin A.; Clem, L. William

doi:10.1016/s0145-305x(79)80042-7

Cited by 42 publications

(26 citation statements)

References 8 publications

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“…Miller & Clem (1984) have shown, using channel catfish, that temperature has an e#ect on the kinetics of the immune response to antigens that do not require the participation of T lymphocytes (T-independent antigens; TI) and was characterized by a Q 10 =2. Similar findings have been reported using carp (Avtalion, 1981), bluegill (Lepomis macrochirus Rafinesque) (Cuchens & Clem, 1977), and salmonids (Fryer et al, 1976). In this study, small temperature di#erences (3 C) had a measurable e#ect on the early kinetics of the response to a TI antigen, TNP-LPS.…”

Section: Discussionsupporting

confidence: 85%

Immunological assessment of hybrid striped bass at three culture temperatures

Carlson

Baker

Fuller

1995

Fish & Shellfish Immunology

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Section: Discussionsupporting

confidence: 85%

Immunological assessment of hybrid striped bass at three culture temperatures

Carlson

Baker

Fuller

1995

Fish & Shellfish Immunology

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“…However, several descriptive reports have described the presence of cellular components of the immune system in the American alligator. Cuchens and Clem (1979) have reported the presence of B-like and T-like lymphocytes in the alligator. In addition, Mateo and coworkers (1984) described the morphological and cytochemical characteristics, and relative abundance of various types of alligator peripheral blood cells.…”

Section: Discussionmentioning

confidence: 99%

Annual and seasonal survival of adult female Mottled Ducks in southern Florida, USA

Varner¹,

Hepp²,

Bielefeld³

2014

The Condor

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“…However, he did not score the severity of disease nor did he clarify whether comparisons of tumored versus non-tumored animals was done with turtles from the same region. Mitogen stimulation of PBMC with PHA and ConA is used as an indicator of T cell-mediated mechanisms of immunity in a wide range of species, and there is considerable evidence for the existence of T and B like cells in reptiles and amphibians (Cuchens and Clem, 1979b;Manickasundari et al, 1984;Negm and Mansour, 1982;El Deeb et al, 1986;El Deeb and Saad, 1987). The correlation between proliferative responses to PHA and ConA for green turtle mono-nuclear cells suggested we were working with a single subpopulation of cells analogous to PHA-inducible T-like lymphocytes of alligators (Cuchens and Clem, 1979a) or thymus dependent ConA-or PHA-inducible cells in frogs (Green and Cohen, 1979).…”

Section: Discussionmentioning

confidence: 99%

“…We used phytohaemagglutinin (PHA) and concanavalin A (ConA) (Sigma) as T-cell mitogens (Benjamini and Leskowitz, 1994;Cuchens and Clem, 1979a;Green and Cohen, 1979). We were primarily interested in evaluating T-like cell response because T-cells are thought to play a major role in tumor immunology (Greenberg, 1994).…”

Section: Methodsmentioning

confidence: 99%

Immune Status of Free-Ranging Green Turtles With Fibropapillomatosis From Hawaii

Work

Rameyer

Balazs

et al. 2001

Journal of Wildlife Diseases

100

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Cell-mediated and humoral immune status of free-ranging green turtles (Chelonia mydas) in Hawaii (USA) with and without fibropapillomatosis (FP) were assessed. Tumored and non-tumored turtles from Kaneohe Bay (KB) on the island of Oahu and from FP-free areas on the west (Kona/Kohala) coast of the island of Hawaii were sampled from April 1998 through February 1999. Turtles on Oahu were grouped (0-3) for severity of tumors with 0 for absence of tumors, 1 for light, 2 for moderate, and 3 for most severe. Turtles were weighed, straight carapace length measured and the regression slope of weight to straight carapace length compared between groups (KB0, KB1, KB2, KB3, Kona). Blood was assayed for differential white blood cell count, hematocrit, in vitro peripheral blood mononuclear cell (PBMC) proliferation in the presence of concanavalin A (ConA) and phytohaemagglutinin (PHA), and protein electrophoresis. On Oahu, heterophil/lymphocyte ratio increased while eosinophil/monocyte ratio decreased with increasing tumors score. Peripheral blood mononuclear cell proliferation indices for ConA and PHA were significantly lower for turtles with tumor scores 2 and 3. Tumor score 3 turtles (KB3) had significantly lower hematocrit, total protein, alpha 1, alpha 2, and gamma globulins than the other four groups. No significant differences in immune status were seen between non-tumored (or KB1) turtles from Oahu and Hawaii. There was no significant difference between groups in regression slopes of body condition to carapace length. We conclude that turtles with severe FP are imunosuppressed. Furthermore, the lack of significant difference in immune status between non-tumored (and KB1) turtles from Oahu and Kona/Kohala indicates that immunosuppression may not be a prerequisite for development of FP.

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Phylogeny of lymphocyte heterogeneity. IV. Evidence for T-like and B-like cells in reptiles

Cited by 42 publications

References 8 publications

Immunological assessment of hybrid striped bass at three culture temperatures

Immunological assessment of hybrid striped bass at three culture temperatures

Annual and seasonal survival of adult female Mottled Ducks in southern Florida, USA

Immune Status of Free-Ranging Green Turtles With Fibropapillomatosis From Hawaii

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