Phylogeny and ontogeny of fish leucocytes

Rombout, J.H.W.M.; Huttenhuis, Heidi B.T.; Picchietti, Simona; Scapigliati, Giuseppe

doi:10.1016/j.fsi.2005.03.007

Cited by 204 publications

(111 citation statements)

References 110 publications

(134 reference statements)

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“…The CK is considered an organ that is similar in terms of function to the mammalian bone marrow (Tomonaga et al, 1973), since it is the principal hematopoietic organ in teleosts (Rombout et al, 2005). Presumably, the wide range of hematopoietic cells observed is not only due to its correspondence with distinct cell lineageserythrocyte, granulocyte, lymphocyte and thrombocyte -but also with differences in their degree of maturation.…”

Section: The Interrenal Gland and Its Contextmentioning

confidence: 99%

The interrenal gland in males of the cichlid fish Cichlasoma dimerus: Relationship with stress and the establishment of social hierarchies

Morandini¹,

Honji²,

Ramallo³

et al. 2014

General and Comparative Endocrinology

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Section: The Interrenal Gland and Its Contextmentioning

confidence: 99%

The interrenal gland in males of the cichlid fish Cichlasoma dimerus: Relationship with stress and the establishment of social hierarchies

Morandini¹,

Honji²,

Ramallo³

et al. 2014

General and Comparative Endocrinology

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“…However, systematic understanding is needed for the changes that occur at the molecular level in different tissues of grass carp during hemorrhagic disease. Innate immunity in fish is investigated mainly because of its importance in the early stages of embryogenesis and of the fundamental defense mechanisms against pathogens (Uribe et al, 2011;Magnadottir, 2006;Rombout et al, 2005). In fact, fish occupy an apparent crossroads between the innate immune response and the evolution of the adaptive immune response (Tort et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

RNA-seq profiles from grass carp tissues after reovirus (GCRV) infection based on singular and modular enrichment analyses

Shi

Huang

et al. 2014

Molecular Immunology

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“…In evolutionary terms, teleosts possess one of the earliest recognizable adaptive immune systems, containing B and T lymphocytes with somatically rearranged antigen receptors, the major histocompatibility complex (MHC), and immunological memory (8,9). Therefore, the presence of DCs in bony fish would provide key information regarding the ontogeny of specific immunity in vertebrates.…”

mentioning

confidence: 99%

Identification of dendritic antigen-presenting cells in the zebrafish

Lugo-Villarino

Balla

Stachura

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

228

157

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In mammals, dendritic cells (DCs) form the key link between the innate and adaptive immune systems. DCs act as immune sentries in various tissues and, upon encountering pathogen, engulf and traffic foreign antigen to secondary lymphoid tissues, stimulating antigenspecific T lymphocytes. Although DCs are of fundamental importance in orchestrating the mammalian immune response, their presence and function in nonmammalian vertebrates is largely unknown. Because teleosts possess one of the earliest recognizable adaptive immune systems, we sought to identify antigen-presenting cells (APCs) in the zebrafish to better understand the potential origins of DCs and their evolutionary relationship to lymphocytes. Here we present the identification and characterization of a zebrafish APC subset strongly resembling mammalian DCs. Rare DCs are present in various adult tissues, and can be enriched by their affinity for the lectin peanut agglutinin (PNA). We show that PNA hi myeloid cells possess the classical morphological features of mammalian DCs as revealed by histochemical and ultrastructural analyses, phagocytose-labeled bacterial preparations in vivo, and exhibit expression of genes associated with DC function and antigen presentation, including il12, MHC class II invariant chain iclp1, and csf1r. Importantly, we show that PNA hi cells can activate T lymphocytes in an antigendependent manner. Together, these studies suggest that the cellular constituents responsible for antigen presentation are remarkably conserved from teleosts to mammals, and indicate that the zebrafish may serve as a unique model to study the origin of APC subsets and their evolutionary role as the link between the innate and adaptive immune systems.

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Phylogeny and ontogeny of fish leucocytes

Cited by 204 publications

References 110 publications

The interrenal gland in males of the cichlid fish Cichlasoma dimerus: Relationship with stress and the establishment of social hierarchies

The interrenal gland in males of the cichlid fish Cichlasoma dimerus: Relationship with stress and the establishment of social hierarchies

RNA-seq profiles from grass carp tissues after reovirus (GCRV) infection based on singular and modular enrichment analyses

Identification of dendritic antigen-presenting cells in the zebrafish

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