Phylogenetic variation of Aggregatibacter actinomycetemcomitans serotype e reveals an aberrant distinct evolutionary stable lineage

Identification of the Pangenome and Its Components in 14 Distinct Aggregatibacter actinomycetemcomitans Strains by Comparative Genomic Analysis

“…Dogan et al [20] distinguished three groups of serotype e strains by AP-PCR typing and by sugar fermentation profiling or two genotypes based on the restriction analysis of the apaH amplification product. Also, two groups of serotype e strains of A. actinomycetemcomitans were identified (e and e′) based on 16S rRNA gene sequence similarity and amplified fragment length polymorphism typing [21]. In this study, strain SC1083 could be assigned to the serotype e′ and the strain SCC393 to the conventional serotype e group based on the signature sequences of the 16S rRNA genes described by Reijden et al [21].…”

“…Also, two groups of serotype e strains of A. actinomycetemcomitans were identified (e and e′) based on 16S rRNA gene sequence similarity and amplified fragment length polymorphism typing [21]. In this study, strain SC1083 could be assigned to the serotype e′ and the strain SCC393 to the conventional serotype e group based on the signature sequences of the 16S rRNA genes described by Reijden et al [21]. It is tempting to speculate that each subtype of serotype e strains may represent a distinct clonal lineage.…”

Serotype‐dependent response of human dendritic cells stimulated with Aggregatibacter actinomycetemcomitans

“…In A. actinomycetemcomitans, six different serotypes are recognized based on the composition and antigenicity of the O-polysaccharide component of the LPS (Page et al 1991, Gmur et al 1993, Kaplan et al 2001, being the serotypes a, b and c, which were analysed in this study, the most prevalent in the oral cavity in humans (Chen et al 2010, van der Reijden et al 2010, Roman-Torres et al 2010, Sakellari et al 2011, Aberg et al 2012, Bandhaya et al 2012, Cortelli et al 2012, Jentsch et al 2012). The polysaccharide portion consists of a core oligosaccharide region and the O-antigen, which constitutes a chain of O-polysaccharide repeating units that stimulate a wide range of immunological and cell responses in the host, which may have important patho-physiological consequences.…”

“…Serotype b has been found more frequently associated with patients with chronic and aggressive periodontitis when compared with healthy individuals and these patients exhibit elevated serum anti-body levels to serotype b-specific antigen (Chen et al 2010, van der Reijden et al 2010, Roman-Torres et al 2010, Sakellari et al 2011, Aberg et al 2012, Bandhaya et al 2012, Cortelli et al 2012, Jentsch et al 2012). Serotype b has been found more frequently associated with patients with chronic and aggressive periodontitis when compared with healthy individuals and these patients exhibit elevated serum anti-body levels to serotype b-specific antigen (Chen et al 2010, van der Reijden et al 2010, Roman-Torres et al 2010, Sakellari et al 2011, Aberg et al 2012, Bandhaya et al 2012, Cortelli et al 2012, Jentsch et al 2012).…”

“…Currently, six A. actinomycetemcomitans serotypes (a-f) are recognized based on the antigenicity of the O-polysaccharide component of the lipopolysaccharide (LPS) (Page et al 1991, Gmur et al 1993, Kaplan et al 2001. Serotypes a, b and c are the most frequent in Caucasians, Asians, Africans and Latin-Americans, being serotype b the most frequently associated with periodontitis (Chen et al 2010, van der Reijden et al 2010, Roman-Torres et al 2010, Sakellari et al 2011, Aberg et al 2012, Bandhaya et al 2012, Cortelli et al 2012, Jentsch et al 2012.…”