Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria

Mazet, Françoise; Yu, Jr-Kai; Liberles, David A.; Holland, Linda Z.; Shimeld, Sebastian M.

doi:10.1016/s0378-1119(03)00741-8

Cited by 105 publications

(110 citation statements)

References 30 publications

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“…Neighbor-joining (NJ) is a methodology for the construction of phylogenetic hypotheses that should be used only to produce a starting tree upon which more thorough searches can be performed (Swofford et al, 1996). Nevertheless, our more rigorous analyses share some features in common with those of past (Lee & Frasch, 2004;Mazet et al, 2003).…”

Section: Discussionmentioning

confidence: 84%

“…Similar searches resulted in the identification of 18 loci from the genome of the malaria mosquito An. gambiae (Mazet et al, 2003), and 16/17 loci from the genome of the fruit fly D. melanogaster (Lee & Frasch, 2004;Mazet et al, 2003). Of possible significance, the number of Fox factors predicted to occur in these three dipteran insects is less than half of that proposed for humans (40 Fox loci for humans are listed at the following web site: http://www.biology.pomona.edu/Fox.html) (Kaestner et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…The Fox subfamilies are a collection of orthologous and paralogous genes (Mazet et al, 2003), with the latter gene duplication events evident in both humans and insects. In Ae.…”

Section: Discussionmentioning

confidence: 99%

“…The nomenclature for the chordate forkhead transcription factors has been revised, and these genes, now termed 'Fox' (after 'Forkhead box'), are divided into seventeen subclasses, or clades, (A to Q), based on the amino acid (AA) sequence of their conserved forkhead domain (Kaestner et al, 2000). Invertebrates share several Fox genes that can be subgrouped according to the vertebrate subfamilies (Mazet et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Forkhead transcription factors regulate mosquito reproduction

Hansen

Sieglaff

Munro

et al. 2007

Insect Biochemistry and Molecular Biology

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Forkhead box (Fox) genes encode a family of transcription factors defined by a 'winged helix' DNAbinding domain. In this study we aimed to identify Fox factors that are expressed within the fat body of the yellow fever mosquito Aedes aegypti, and determine whether any of these are involved in the regulation of mosquito yolk protein gene expression. The Ae. aegypti genome contains eighteen loci that encode putative Fox factors. Our stringent cladistic analysis has profound implications for the use of Fox genes as phylogenetic markers. Twelve Ae. aegypti Fox genes are expressed within various tissues of adult females, six of which are expressed within the fat body. All six Fox genes expressed in the fat body displayed dynamic expression profiles following a blood meal. We knocked down the 'fat body Foxes' through RNAi to determine whether these "knockdowns" hindered amino acidinduced vitellogenin gene expression. We also determined the effect of these knockdowns on the number of eggs deposited following a blood meal. Knockdown of FoxN1, FoxN2, FoxL, and FoxO, had a negative effect on amino acid-induced vitellogenin gene expression and resulted in significantly fewer eggs laid. Our analysis stresses the importance of Fox transcription factors in regulating mosquito reproduction.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

“…The Fox subfamilies are a collection of orthologous and paralogous genes (Mazet et al, 2003), with the latter gene duplication events evident in both humans and insects. In Ae.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Forkhead transcription factors regulate mosquito reproduction

Hansen

Sieglaff

Munro

et al. 2007

Insect Biochemistry and Molecular Biology

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“…The FOX domain is also known as winged-helix domain with two wing-like loops and three α-helices structure (Kaestner et al, 2000). Genome-based bioinformatics analyses have showed that FOX proteins comprise a large family members identified in species ranging from yeasts to humans, and have been classified into different subfamilies (Kaestner et al, 2000;Mazet et al, 2003;Wotton et al, 2006;Tu et al, 2006;Benayoun et al, 2011). Animals appeared to have more FOX genes than fungi, for example, with 4 genes identified in Saccharomyces and Schizosaccharomyces, and over 50 members in the human (Wotton et al, 2006;Benayoun et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Expression Analysis Suggests Functional Overlapping of Human FOX Transcription Factors in Cancer

Zhang¹,

FengTing²,

Zhang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Forkhead-box (FOX) transcription factors comprise a large gene family that contains more than 50 members in man. Extensive studies have revealed that they not only have functions in control of growth and development, but also play important roles in different diseases, especially in cancer. However, biological functions for most of the members in the FOX family remain unknown. In the present study, the expression of 39 FOX genes in 48 kinds of cancer was mined from the Gene Expression Atlas database of European Bioinformatics Institute. The analysis results showed that some FOX genes demonstrate overlapping expression in various cancers, which suggests particular biological functions. The pleiotropic features of the FOX genes make them excellent candidates in efforts aimed to give medical treatment for cancers at the genetic level. The results also indicated that different FOX genes may have the synergy or antagonistics effects in the same cancers. The study provides clues for further functional analysis of FOX genes, especially for the pleiotropic biological functions and crosstalk of FOX genes in human cancers.

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Variation and Conservation of the Development of Animal Bodies: Evolutionary Developmental Biology

Mazet¹,

Shimeld²

2006

Encyclopedia of Molecular Cell Biology and Molecular Medicine

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Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria

Cited by 105 publications

References 30 publications

Forkhead transcription factors regulate mosquito reproduction

Forkhead transcription factors regulate mosquito reproduction

Comprehensive Expression Analysis Suggests Functional Overlapping of Human FOX Transcription Factors in Cancer

Variation and Conservation of the Development of Animal Bodies: Evolutionary Developmental Biology

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