Phylogenetic inference identifies two eumetazoan TRPM clades and an 8^th family of TRP channel, TRP soromelastatin (TRPS)

Abstract

1TRP melastatins (TRPMs) are most well-known as cold and menthol sensors, but are in fact 2 broadly critical for life, from ion homeostasis to reproduction. Yet the evolutionary relationship 3 between TRPM channels remains largely unresolved, particularly with respect to the placement 4 of several highly divergent members. To characterize the evolution of TRPM and like channels, 5 we performed a large-scale phylogenetic analysis of >1,300 TRPM-like sequences from 14 phyla 6