Phylogenetic evidence of a new canine distemper virus lineage among domestic dogs in Colombia, South America

Espinal, Maria A.; Díaz, Francisco J.; Ruíz-Saenz, Julián

doi:10.1016/j.vetmic.2014.05.019

Cited by 45 publications

(45 citation statements)

References 30 publications

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“…They generally contain the CDV strains Rockborn, Snyder Hill, Onderstepoort, Lederle or others at various titres. There are many pathotypes of CDV (Kapil et al 2008, Espinal et al 2014 which can cause varying clinical signs in a wide variety of species. However, serological differences among the many isolates are insignificant, and vaccination with any one of the current vaccines should provide protective immunity against any pathotype.…”

Section: Types Of Vaccines Availablementioning

confidence: 99%

WSAVA Guidelines for the vaccination of dogs and cats

Day

Horzinek

Schultz

et al. 2016

J of Small Animal Practice

245

389

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Section: Types Of Vaccines Availablementioning

confidence: 99%

WSAVA Guidelines for the vaccination of dogs and cats

Day

Horzinek

Schultz

et al. 2016

J of Small Animal Practice

245

389

View full text Add to dashboard Cite

“…CDV has been classified into several genetic lineages based on diversity among strains from distinct geographic locations. There are 7 major CDV lineages, America-1, America-2, European, European Wildlife, Asia-1, Asia-2, and Arctic like [13], as well as some additional proposed ones that have been more recently discovered, including Asia-3 [14], Asia-4 [15], Africa [13], Europe/South America 1 (European), South America 2, and South America 3 [16][17][18][19]. The Onderstepoort and Snyder Hill strains, members of the America-1 lineage, were used widely to produce the distemper vaccines in the 1950s, and these are the same vaccines used today.…”

Section: Introductionmentioning

confidence: 99%

Rapid and sensitive detection of canine distemper virus by one-tube reverse transcription-insulated isothermal polymerase chain reaction

et al. 2014

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BackgroundCanine distemper virus (CDV) has been associated with outbreaks of canine infectious respiratory disease in shelters and boarding kennel environments. POCKITTM Nucleic Acid Analyzer is a field-deployable device capable of generating automatically interpreted insulated isothermal polymerase chain reaction (iiPCR) results from extracted nucleic acid within one hour. In this study, reverse transcription iiPCR (RT-iiPCR) was developed to facilitate point-of-need diagnosis of CDV infection.ResultsAnalytical sensitivity (limit of detection 95%) of the established CDV RT-iiPCR was about 11 copies of in vitro transcribed RNA per reaction. CDV RT-iiPCR generated positive signals from CDV, but not Bordetella bronchiseptica, canine parvovirus, canine herpesvirus, canine adenovirus 2, canine influenza virus (subtype H3N8), canine parainfluenza virus, and canine respiratory coronavirus. To evaluate accuracy of the established reaction in canine distemper clinical diagnosis, 110 specimens from dogs, raccoons, and foxes suspected with CDV infection were tested simultaneously by CDV RT-iiPCR and real-time RT-PCR. CDV RT-iiPCR demonstrated excellent sensitivity (100%) and specificity (100%), compared to real-time RT-PCR.ConclusionsThe results indicated an excellent correlation between RT-iiPCR and a reference real time RT-PCR method. Working in a lyophilized format, the established method has great potential to be used for point-of-care diagnosis of canine distemper in animals, especially in resource-limited facilities.

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“…However, the Brazilian CDVs varied over 4% compared to the strains belonging to South America 2 (PANZERA et al, 2012) and South America 3 lineages (ESPINAL et al, 2014), demonstrating that these CDVs are grouped with strains from different lineages. This finding is consistent with the report by Budaszewski et al (2014) and Panzera et al (2015), who considered the South America 1 and Europe 1 belonging to same clade and the same lineage.…”

mentioning

confidence: 96%

Caracterização genética do gene da hemaglutinina em vírus da cinomose canina de cães naturalmente infectados no Brasil

Cortéz

Heinemann

Fonseca

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

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Canine distemper is one of the major infectious diseases in dogs and wild animals, resulting in high morbidity and mortality. The H gene has the greatest genetic variability among the genes encoded by the canine distemper virus (CDV) genome, and it has been used to characterise field samples, allowing the identification of specific lineages. Variation in the H gene can allow the virus to evade recognition by vaccine-induced antibodies, resulting in vaccine failure. The purpose of this study was to characterise H gene in CDV strains from naturally infected dogs in the state of São Paulo. The phylogenetic analysis revealed that Brazilian CDV strains were genetically related to the circulating CDV strains in Uruguay, Argentina, and Europe. We found no evidence of South America 2 and 3 CDV lineages circulating in Brazilian dogs. The degree of genetic divergence between wild Brazilian CDV strains and vaccine strains may suggest the possibility of vaccine failures and consequently the occurrence of canine distemper outbreaks. Keywords: Brazil. South America. Canine distemper virus. Haemagglutinin (H) gene. Phylogenetic analysis. ResumoA cinomose canina é uma das principais doenças infecciosas em cães e animais selvagens, resultando em alta morbidade e mortalidade. O gene H tem uma das maiores variabilidades genéticas entre os genes codificados pelo vírus da cinomose canina (CDV), e tem sido utilizado para caracterizar as estirpes de CDV, permitindo a identificação de linhagens específicas. A variação no gene H pode permitir que o vírus evite o reconhecimento por anticorpos induzidos pela vacina, resultando em falha vacinal. O objetivo deste estudo foi caracterizar o gene H em estirpes de CDV de cães infectados naturalmente no estado de São Paulo. A análise filogenética revelou que as estirpes de CDV brasileiras estão geneticamente relacionadas as estirpes circulantes no Uruguai, na Argentina e na Europa. Não foi encontrada nenhuma evidência da circulação no estado de São Paulo das linhagens América do Sul 2 e 3. O grau de divergência genética entre linhagens selvagens de CDV brasileiras e as estirpes vacinais podem sugerir a possibilidade de falhas vacinais e consequentemente a ocorrência de surtos de cinomose canina. Palavras-chave: Brasil. América do Sul. Vírus da cinomose canina. Gene da hemaglutinina. Análise filogenética.Canine distemper is one of the major infectious diseases in dogs and wild animals, resulting in high morbidity and mortality. The canine distemper virus (CDV) belongs to the genus Morbillivirus of the Paramyxoviridae family. CDV is an enveloped negative single-stranded RNA virus, and its genome encodes six structural proteins; the Haemagglutinin (H) glycoprotein has been used to characterize field strains (MARTELLA

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Phylogenetic evidence of a new canine distemper virus lineage among domestic dogs in Colombia, South America

Cited by 45 publications

References 30 publications

WSAVA Guidelines for the vaccination of dogs and cats

WSAVA Guidelines for the vaccination of dogs and cats

Rapid and sensitive detection of canine distemper virus by one-tube reverse transcription-insulated isothermal polymerase chain reaction

Caracterização genética do gene da hemaglutinina em vírus da cinomose canina de cães naturalmente infectados no Brasil

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