Phylogenetic diversity of stress signalling pathways in fungi

Nikolaou, Elissavet; Agrafioti, Ino; Stumpf, Michael; Quinn, Janet; Stansfield, Ian; Brown, Alistair J. P.

doi:10.1186/1471-2148-9-44

Cited by 177 publications

(202 citation statements)

References 154 publications

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“…but many upstream sensors and downstream transcriptional regulators have diverged substantially 9 . On this basis one might have expected the heat shock response to have diverged in fungi that inhabit thermally buffered niches, such as the clinically important pathogen C. albicans 10 , which is obligately associated with warm-blooded animals 11 .…”

Section: Introductionmentioning

confidence: 99%

Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs

et al. 2012

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Preface Hsp90 is an essential, abundant, and ubiquitous eukaryotic chaperone that has crucial roles in protein folding and modulates the activities of key regulators. The fungal Hsp90 interactome, which includes numerous client proteins such as receptors, protein kinases and transcription factors, displays a surprisingly high degree of plasticity that depends on environmental conditions. Furthermore, although Hsp90 levels increase following environmental challenges, Hsp90 activity is tightly controlled via post-translational regulation and an autoregulatory loop involving the heat shock transcription factor, Hsf1. In this review, we discuss the roles and regulation of Hsp90. We propose that Hsp90 acts as a biological transistor that modulates the activity of fungal signalling networks in response to environmental cues via this Hsf1-Hsp90 autoregulatory loop.

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Section: Introductionmentioning

confidence: 99%

Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs

et al. 2012

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“…However, studies designed to elucidate the cellular mechanisms that trigger toxicity and cell death have been reported in this yeast system (Braun et al, 2009). In the current investigation, we chose C. albicans strain CC504 as a test organism since in previous studies strains of C. albicans appeared Manen et al 71 to be more resistance to oxidative stress induced by different chemicals tested and hyphal filaments were readily demonstrable under defined growth conditions (Chandra et al, 2001;Whiteway et al, 2007;Nikoloau et al, 2009;Jamieson et al, 1996). We have demonstrated in control experiments, that parental cells and the CC504-CMV derivative strain did not exhibit immunolabeling with anti-tau antibody, which suggests that C. albicans does not contain a protein with epitopes similar to the human tau protein.…”

Section: Discussionmentioning

confidence: 99%

Expression of neuronal protein Tau in Candida albicans

Manen¹,

Guariglia²,

Alonso³

et al. 2014

J. Yeast Fungal Res.

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Candida albicans is a dimorphic, opportunist fungal pathogen in which cell adhesion and filamentation contribute to host tissue invasiveness and fungal pathogenicity. Morphogenesis in C. albicans which involves yeast to hyphae transition is dependent on temperature, the growth media composition, and is regulated by quorum sensing. In yeasts, filament formation and polarized growth are associated with the actin cytoskeletal network and microtubule interactions. The microtubule associated protein (MAP), Tau (tau), is a neuronal protein in mammals that participates in microtubule binding, microtubule assembly, bundling and stabilization. In the current study, we generated an electroporated tau derivative of a strain of C. albicans. We have observed that tau expression accelerates and increases the extent of medium dependent filamentation. We have also noted tau interacts mainly with actin filaments and to some extent, microtubules. We believe that these interactions are involved in the temporal control of filament formation in tau-containing cells.

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“…While we have earlier commented on the evolutionary conservation of stress response elements, a comparative study of fungal stress responses by Nikolaou et al (2009) has revealed a more nuanced situation. When stress response pathways are compared across several fungal species, it is found that there is extensive, niche-specific divergence of sensory and response elements, whereas core components of pathways (especially multifunctional components) are phylogenetically conserved.…”

Section: Future Perspectivesmentioning

confidence: 99%