Phylogenetic Comparison between Italian and Worldwide Hericium Species (Agaricomycetes)

Cesaroni, Valentina; Brusoni, Maura; Cusaro, Carlo Maria; Girometta, Carolina Elena; Perini, Claudia; Picco, Anna Maria; Rossi, Paola; Salerni, Elena; Savino, Elena

doi:10.1615/intjmedmushrooms.2019032561

Cited by 9 publications

(10 citation statements)

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“…The strain obtained from the WT was confirmed to belong to H. erinaceus [28] and is maintained in the Fungal Research Culture Collection of Pavia University (MicUNIPV) as H.e.2.…”

Section: Resultsmentioning

confidence: 99%

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Array of Metabolites in Italian Hericium erinaceus Mycelium, Primordium, and Sporophore

et al. 2019

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Hericium erinaceus is a medicinal mushroom that contains many molecules promising a plethora of therapeutic properties. In this study, the strain H.e.2 (MicUNIPV, University of Pavia, Italy) was isolated from a sporophore collected in Tuscany (Italy). Mycelium, primordium, and wild type and cultivated sporophores were analyzed by HPLC-UV-ESI/MS. Erinacine A in the mycelium and hericenones C and D in the sporophores were quantified by comparison with their standard molecules. For the first time, H. erinaceus primordium was also investigated for the presence of these molecules. Comparing with the literature data, hericenes, molecules structurally similar to hericenones, were present in all our samples. The highest contents of hericenones C and D were detected in cultivated sporophores, compared to the wild type. The comparison of these data with those of another Italian H. erinaceus strain (H.e.1 MicUNIPV) was discussed. The results led us to select H. erinaceus strains more suitable for mycelium production or sporophore cultivation to obtain extracts with a higher content of bioactive compounds. This work provides a further step towards standardizing the procedures in the development of dietary supplements made from mushrooms.

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“…The strain obtained from the WT was confirmed to belong to H. erinaceus [28] and is maintained in the Fungal Research Culture Collection of Pavia University (MicUNIPV) as H.e.2.…”

Section: Resultsmentioning

confidence: 99%

“…In MicUNIPV, the Fungal Research Culture Collection at the University of Pavia (Italy), two strains of H. erinaceus collected in Italy are present to date: H.e.1 and H.e.2 [10,28]. The content of erinacine A in H.e.2 (105 µg/g) is slightly less compared to H.e.1 mycelium (150 µg/g) [10].…”

Section: Discussionmentioning

confidence: 99%

Array of Metabolites in Italian Hericium erinaceus Mycelium, Primordium, and Sporophore

et al. 2019

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“…The He1 (strain 1 of H. erinaceus ) was isolated from a basidioma collected in 2013 in Siena province (Region Tuscany, Italy) from a live specimen of Quercus ilex [38]. The basidioma was aseptically cut in small portions (about 1 mm 3 ) that were placed into Petri dishes with 2% malt extract agar as a culture medium (MEA, Biokar Diagnostics).…”

Section: Methodsmentioning

confidence: 99%

Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging

et al. 2019

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Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests and by studying the dynamic change during aging, we demonstrated that the two form of vulnerability, locomotor and recognition memory decline, develop in parallel and therefore, integration of the motoric and cognitive evaluations are imperative. We developed an integrated frailty index based on both phenotypic and recognition memory performances. Hericium erinaceus (H. erinaceus) is a medicinal mushroom that improves recognition memory in mice. By using HPLC-UV-ESI/MS analyses we obtained standardized amounts of erinacine A and hericenones C and D in H. erinaceus extracts, that were tested in our animal model of physiological aging. Two-month oral supplementation with H. erinaceus reversed the age-decline of recognition memory. Proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunohistochemistry in the hippocampus and cerebellum in treated mice supported a positive effect of an H. erinaceus on neurogenesis in frail mice.

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“…The He1 (strain 1 of H. erinaceus) was isolated from a wildtype sporophore collected in 2013 in Siena province (Tuscany, Italy) from a Quercus ilex [97]. The sporophore was aseptically cut and placed in 2% malt extract agar as a culture medium (MEA, Biokar Diagnostics) [14].…”

Section: H Erinaceusmentioning

confidence: 99%

Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging

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et al. 2021

IJMS

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Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., inflammaging. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of H. erinaceus, containing a known amount of Erinacine A, Hericenone C, Hericenone D, and L-ergothioneine, on locomotor frailty and cerebellum of aged mice. Locomotor performances were monitored comparing healthy aging and frail mice. Cerebellar volume and cytoarchitecture, together with inflammatory and oxidative stress pathways, were assessed focusing on senescent frail animals. H. erinaceus partially recovered the aged-related decline of locomotor performances. Histopathological analyses paralleled by immunocytochemical evaluation of specific molecules strengthened the neuroprotective role of H. erinaceus able to ameliorate cerebellar alterations, i.e., milder volume reduction, slighter molecular layer thickness decrease and minor percentage of shrunken Purkinje neurons, also diminishing inflammation and oxidative stress in frail mice while increasing a key longevity regulator and a neuroprotective molecule. Thus, our present findings demonstrated the efficacy of a non-pharmacological approach, based on the dietary supplementation using H. erinaceus extract, which represent a promising adjuvant therapy to be associated with conventional geriatric treatments.

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Phylogenetic Comparison between Italian and Worldwide Hericium Species (Agaricomycetes)

Cited by 9 publications

References 0 publications

Array of Metabolites in Italian Hericium erinaceus Mycelium, Primordium, and Sporophore

Array of Metabolites in Italian Hericium erinaceus Mycelium, Primordium, and Sporophore

Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging

Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging

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