Phylogenetic Comparison Between Archetypal and Disease-Associated Jc Virus Isolates in Japan

Kato, Kenzo; Guo, Jing; Taguchi, Fumiaki; Daimaru, Osami; Tajima, Makoto; Haibara, Hideyuki; Matsuda, Juzo; Sumiya, M; Yogo, Yoshiaki

doi:10.7883/yoken1952.47.167

Cited by 23 publications

(12 citation statements)

References 19 publications

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“…Furthermore, none of the clones carried both a deletion and a duplication. Accordingly, we concluded that JCVs with PML type regulatory sequences which have extensive sequence rearrangements (Martin et al, 1985;Matsuda et al, 1987;Loeber & Domes, 1988;Takahashi et al, 1992;Ault & Stoner, 1993;Yogo et al, 1994;Kato et al, 1994) do not circulate in the human population.…”

Section: Regulatory Sequences Of Cloned Jc V Dnasmentioning

confidence: 90%

“…There are two forms of JCV regulatory sequences, one (archetype) that can be detected in isolates from the urine as well as the kidney of non-PML individuals (Yogo et al, , 1991aFlaegstad et al, 1991;Markowitz et al, 1991;Tominaga et al, 1992) and one (PML type) that can be detected in isolates from the brains of PML patients (Martin et al, 1985;Matsuda et al, 1987, Loeber & D6rries, 1988Takahashi et al, 1992;Ault & Stoner, 1993;Yogo et al, 1994;Kato et al, 1994). The former may have generated the latter during the course of persistence in patients (Yogo et al, , 1991Iida et al, 1993;Ault & Stoner, 1993).…”

Section: Regulatory Sequences Of Cloned Jc V Dnasmentioning

confidence: 99%

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Geographical distribution of the human polyomavirus JC virus types A and B and isolation of a new type from Ghana

Guo

Kitamura

Ebihara

et al. 1996

Journal of General Virology

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The JC polyomavirus (JCV) is ubiquitous in humans, infecting children asymptomatically, then persisting in renal tissue. Since JCV DNA can be readily isolated from urine, it should be a useful tool with which to study the evolution of DNA viruses in humans. We showed that JCV DNA from the urine of Japanese, Taiwanese, Dutch and German patients can be classified into A and B types, based upon restriction fragment length polymorphisms (RFLPs). This work was extended in the present study. We established multiple JCV DNA clones from the UK, Spain, Italy, Sweden, South Korea, People's Republic of China, Malaysia, Indonesia, Mongolia, India, Sri Lanka, Saudi Arabia, Ethiopia, Kenya, Zambia, South Africa and Ghana. Using typespecific RFLPs, most clones except the four clones from Ghana were classified as either type A or B. We constructed a molecular phylogenetic tree for the Ghanaian clones and several representative type A and B clones. According to the phylogenetic tree, the Ghanaian clones constituted a major new group, tentatively named type C. From the findings presented here and elsewhere, the following conclusions were drawn: (i) type A is prevalent only in Europe; (ii) type B is found mainly in Asia and Africa; and (iii) type C is localized to part of Africa. Our findings should help to clarify how JCV evolved in humans.

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Section: Regulatory Sequences Of Cloned Jc V Dnasmentioning

confidence: 90%

Section: Regulatory Sequences Of Cloned Jc V Dnasmentioning

confidence: 99%

Geographical distribution of the human polyomavirus JC virus types A and B and isolation of a new type from Ghana

Guo

Kitamura

Ebihara

et al. 1996

Journal of General Virology

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“…The viruses appear to be latent in the medulla of the kid ney [79]. Comparing virus isolates obtained from the brain and kidney of a PML case, significant differences in the OR I have been described, resulting in the loss of one of the two tandem repeat sequences in the kidney [80], Based on the sequence analysis two major groups of JCV isolates may be distinguished [81 ]. Variations in the ORI found in various patients have led to the concept of an archetypal ORI which evolves by deletion and amplification into the ORI types found in PML brain tissue [82],…”

Section: Latency and Persistencementioning

confidence: 99%

Progressive Multifocal Leukoencephalopathy: Molecular Biology, Pathogenesis and Clinical Impact

1997

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The human polyomaviruses JC virus (JCV) and BK virus (BKV) have long been known as onco- and neurooncogenic. Interest in their oncogenic potential has reemerged with the discovery of simian virus 40 DNA in human brain tumors including the pituitary as well as in bone tumors and mesotheliomas. The only human disease caused by an infection with the human polyomavirus JCV is progressive multifocal leukoencephalopathy (PML) characterized by a lytic infection of oligodendrocytes with consecutive demyelination. Malignant transformation of cell lines appears to be caused by a complex interaction of the viral large T (tumor) antigen with several transcription factors and tumor suppressor proteins such as p53 and the retinoblastoma protein. PML, once an extremely rare disease, has become much more frequent in the western world owing to the AIDS pandemic. An exceedingly complicated, cell-, tissue- and species-specific pattern of protein-DNA interaction and negative as well as positive feedback regulation by at least a dozen proteins and possibly mutations in the JC viral promoter-enhancer region govern host range and development of PML. The intricate molecular and immunological prerequisites ultimately leading to PML in humans have not yet been completely elucidated.

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“…PML-type regulatory regions are generated from the archetype by deletions and/or duplications in infected individuals after the primary infection, and they differ from patient to patient (12,13). Representative recombinant JC virus DNA clones detected in each patient were sequenced as described previously (12,14). A comparison of the regulatory region sequences revealed that they were distinct from each other, and the positions and patterns of the deletions and duplications were case specific, since each had its own specific progenitor clones (Figure 2).…”

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confidence: 99%

Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus

Itoh

Kano

Nagashio

et al. 2006

Arthritis & Rheumatism

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Phylogenetic Comparison Between Archetypal and Disease-Associated Jc Virus Isolates in Japan

Cited by 23 publications

References 19 publications

Geographical distribution of the human polyomavirus JC virus types A and B and isolation of a new type from Ghana

Geographical distribution of the human polyomavirus JC virus types A and B and isolation of a new type from Ghana

Progressive Multifocal Leukoencephalopathy: Molecular Biology, Pathogenesis and Clinical Impact

Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus

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