Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus

Teixeira, Marcus M.; Theodoro, Raquel Cordeiro; Carvalho, Maria J.A. de; Fernandes, Larissa; Paes, Hugo Costa; Hahn, Rosane Christine; Mendoza, Leonel; Bagagli, Eduardo; San-Blas, Gioconda; Felipe, Maria Sueli Soares

doi:10.1016/j.ympev.2009.04.005

Cited by 299 publications

(389 citation statements)

References 62 publications

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“…Suspected colonies were subjected to HSP70 gene amplification using the primers HSPMMT1 and PLMMT1 as described by Teixeira and others 4 to identify an exclusive indel region of P. lutzii. The clinical isolate (no.…”

Section: Resultsmentioning

confidence: 99%

“…These sequences were previously deposited at GenBank (http://www.ncbi.nlm.nih.gov/genbank/) and described by Matute and others, 3 Teixeira and others, 4 and Marquesda-Silva and others. 7 The nucleotide sequences were aligned using the Simultaneous Alignment and Tree Estimation software (SATé 2.2.2).…”

Section: Resultsmentioning

confidence: 99%

“…For a century, the etiological agent of PCM has been attributed to the species P. brasiliensis s.l., which was previously assumed to be a monotypic taxon, although recent publications 3,4 support the idea of several cryptic phylogenetically related species in a complex. The real incidence of each phylogenetic species and its implication on ecology and clinical practice is difficult to establish because of a lack of information in the literature in regards to the distribution of these entities.…”

mentioning

confidence: 91%

“…Recent studies revealed high genetic variability among isolates that were morphologically identified as Paracoccidioides brasiliensis, 3,4 which has led to the recognition and introduction of new pathogenic species. The phylogenetic species embedded in the P. brasiliensis complex include S1 (species 1), PS2 (phylogenetic species 2), PS3 (phylogenetic species 3), and PS4 (phylogenetic species 4), whereas the clade harboring the isolate Pb01 is placed at a relatively large distance from the P. brasiliensis complex and currently is refereed as a new biological species Paracoccidioides lutzii, which is prevalent in the central-west region of Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Fatal Fungemia due to Paracoccidioides lutzii

Hahn

Rodrigues

Fontes

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Fatal Fungemia due to Paracoccidioides lutzii

Hahn

Rodrigues

Fontes

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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“…In spite of the small number of patients observed and the limitations of this study, this observation could raise the hypothesis of the presence of different Pb strains or even Paracoccididoides species in this region which could be more prone to invade the CNS. In fact, there is a trend in the literature to define new Paracoccidioides species, with diverse geographical distributions and possibly different pathogenic patterns 21 .…”

Section: Conflict Of Interest Financial Supportmentioning

confidence: 99%

Paracoccidioidomycosis case series with and without central nervous system involvement

Pedroso

Lyon

Araújo

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Paracoccidioidomycosis (PCM) is the most important systemic mycosis in South America. Central nervous system involvement is potentially fatal and can occur in 12.5% of cases. This paper aims to contribute to the literature describing eight cases of neuroparacoccidioidomycosis (NPMC) and compare their characteristics with patients without neurological involvement, to identify unique characteristics of NPCM. Methods: A cohort of 213 PCM cases was evaluated at the Infectious Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, from October 1976 to August 2008. Epidemiological, clinical, laboratory, therapeutic and follow-up data were registered. Results: Eight patients presented NPCM. The observed NPCM prevalence was 3.8%. One patient presented the subacute form of PCM and the other seven presented the chronic form of the disease. The parenchymatous form of NPCM occurred in all patients. 60% of the patients who proceeded from the north/ northeast region of Minas Gerais State developed NPCM. The neurological involvement of a mother and her son was observed. NPCM patients exhibited demographical and clinical profiles similar to what is described in the literature. When NPCM cases were compared to PCM patients, there were differences in relation to origin and positive PCM family history. Conclusions: The results corroborate the clinical view that the neurological findings are extremely important in the evaluation of PCM patients. Despite the limitations of this study, the differences in relation to patient's origins and family history point to the need of further studies to determine the susceptibility factors involved in the neurological compromise.

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Paracoccidioidomycosis

2011

Fundamental Medical Mycology

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RESUMENLa paracoccidioidomicosis es una de las micosis profundas más prevalentes en América Latina, causada por el hongo dimófico Paracoccidioides brasiliensis. La enfermedad presenta gran variabilidad clínica y se divide en dos formas de presentación. La forma aguda, que es la menos frecuente (3%-5% de los casos). Y la crónica, la más frecuente (>90% de los casos), que afecta principalmente a hombres mayores de 20-30 años. El diagnóstico se basa en la clínica, visualización microscópica de elementos fúngicos sugestivos de P. brasiliensis, cultivo del hongo de especímenes clínicos, pruebas serológicas, y otros exámenes como rayos X/tomografía axial computarizada (TAC) de acuerdo con la forma y presentación clínica. Cuando se confirma el diagnóstico, todos los pacientes deben recibir tratamiento. Los más usados son el itraconazol y el trimetropim/sulfametoxazol (TMP/ SMX). La anfotericina B se reserva para casos más severos. Las tasas de recaídas son poco frecuentes en aquellos pacientes que reciben un tratamiento completo y adecuado. Sin embargo, estas aumentan si se trata de pacientes inmunocomprometidos o aquellos que suspenden el tratamiento antes de cumplir con los criterios de curación. Es importante realizar un diagnóstico oportuno para evitar las secuelas producidas por la enfermedad, las cuales son más comunes en los pacientes con paracoccidioidomicosis crónica. Palabras clave: micosis; paracoccidioidomicosis; diagnóstico diferencial. ABSTRACTParacoccidioidomycosis is one of the most prevalent systemic mycoses in Latin America. Caused by the dimorphic fungus Paracoccidioides brasiliensis, the disease may have a broad clinical spectrum, and is divided into two forms: the acute form, the least frequent (3%-5% of cases), and the chronic form, the most common (>90% of cases), which primarily affects men aged 20-30 years. The diagnosis is based on clinical presentation, microscopic visualization of the fungus suggestive of P. brasiliensis, culture of the fungus, serology, and other tests, such as X-ray or CT scan, depending on the clinical presentation. Upon diagnosis, all patients must receive treatment. The most common treatments are itraconazole and trimethoprim/sulfamethoxazole; amphotericin B is reserved for severe cases. Relapse rates are infrequent in those who receive the entire treatment. However, they may increase in patients who are immunocompromised or those who stop the treatment before meeting the cure criteria. Developments of sequelae are more common in the chronic form. Thus, early diagnosis is important in order to prevent disabling sequelae caused by the disease.

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Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus

Cited by 299 publications

References 62 publications

Fatal Fungemia due to Paracoccidioides lutzii

Fatal Fungemia due to Paracoccidioides lutzii

Paracoccidioidomycosis case series with and without central nervous system involvement

Paracoccidioidomycosis

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