Phylogenetic analysis of torque teno virus in Romania: possible evidence of distinct geographical distribution

Spandole-Dinu, Sonia; Cimponeriu, Danut; Stoica, Ileana; Apircioaie, Oana; Gogianu, Larisa; Berca, Lavinia Mariana; Nica, Silvia; Toma, M.; Nica, Remus

doi:10.1007/s00705-022-05559-8

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…TTV load is also significantly increased in patients with autoimmune inflammatory diseases [ 124 ]. People infected with TTV can probably get autoimmune diseases or have their severity affected due to the effect of this virus on the host’s immune system and its modulation [ 125 , 126 ]. Also, the increase in TTV DNA load in people with systemic lupus erythematosus, which is an autoimmune disease, is significant compared to healthy people.…”

Section: Immune System Diseasesmentioning

confidence: 99%

The mysterious anelloviruses: investigating its role in human diseases

Sabbaghian,

Gheitasi,

Shekarchi

et al. 2024

BMC Microbiol

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Anelloviruses (AVs) that infect the human population are members of the Anelloviridae family. They are widely distributed in human populations worldwide. Torque teno virus (TTV) was the first virus of this family to be identified and is estimated to be found in the serum of 80–90% of the human population. Sometime after the identification of TTV, Torque teno mini virus (TTMV) and Torque teno midi virus (TTMDV) were also identified and classified in this family. Since identifying these viruses, have been detected in various types of biological fluids of the human body, including blood and urine, as well as vital organs such as the liver and kidney. They can be transmitted from person to person through blood transfusions, fecal-oral contact, and possibly sexual intercourse. Recent studies on these newly introduced viruses show that although they are not directly related to human disease, they may be indirectly involved in initiating or exacerbating some human population-related diseases and viral infections. Among these diseases, we can mention various types of cancers, immune system diseases, viral infections, hepatitis, and AIDS. Also, they likely use the microRNAs (miRNAs) they encode to fulfill this cooperative role. Also, in recent years, the role of proliferation and their viral load, especially TTV, has been highlighted to indicate the immune system status of immunocompromised people or people who undergo organ transplants. Here, we review the possible role of these viruses in diseases that target humans and highlight them as important viruses that require further study. This review can provide new insights to researchers.

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Section: Immune System Diseasesmentioning

confidence: 99%

The mysterious anelloviruses: investigating its role in human diseases

Sabbaghian,

Gheitasi,

Shekarchi

et al. 2024

BMC Microbiol

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Detection and Genomic Characterization of Torque Teno Virus in Pneumoconiosis Patients in China

Yu,

Wang,

Liu

et al. 2024

Viruses

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Pneumoconiosis is a common occupational disease that can worsen with accompanying infection. Torque teno virus (TTV) is a prevalent human virus with multiple genotypes that can chronically and persistently infect individuals. However, the prevalence of TTV in pneumoconiosis patients is still unclear. This research aims to detect the presence and prevalence of TTV in the alveolar lavage fluid of pneumoconiosis patients in the Hunan Province of China using PCR. As a result, a 65.5% positive rate (19 out of 29) of TTV was detected. The TTV detection rate varies among different stages of silicosis and different pneumoconiosis patient ages. Nine novel TTV genomes ranging in size from 3719 to 3908 nt, named TTV HNPP1, HNPP2, HNPP3, HNPP4, HNPP5, HNPP6-1, HNPP6-2, HNPP7-1 and HNPP7-2, were identified. A genomic comparison and phylogenetic analysis indicated that these nine TTVs represent five different species with high genetic diversity which belong to the genus Alphatorquevirus. HNPP6-1 and HNPP6-2 belong to TTV3, HNPP5 belongs to TTV13, HNPP1 belongs to TTV24, HNPP4 belongs to TTV20, and the others belong to TTV19. The genomes of TTV HNPP1, HNPP6-1, and HNPP6-2 contain three putative open reading frames (ORFs) coding for proteins, ORF1, ORF2, and ORF3, while the other six TTV genomes contain two ORFs coding for proteins, ORF1 and ORF2. These results provide the first description of TTV epidemiology in pneumoconiosis patients in China. The newly identified TTV genome sequences reveal the high genetic diversity of TTV in pneumoconiosis patients and could contribute to a deeper understanding of TTV retention and infection in humans.

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Investigating the Role of Dopamine Signaling Gene Polymorphisms and Prevalence of Human Anelloviruses Infection in Substance Abuse

Spandole-Dinu,

Radu,

Andone

2023

Roum Arch Microbiol Immunol

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The dopaminergic system plays a major role in consolidating the effects and dependence of abused substances. Unlike monogenic diseases, psychiatric disorders – including substance abuse and addiction – are multifactorial disorders in which genetic factors, with varying contributions to the phenotype, and environmental factors are involved. This study aimed to investigate the association between polymorphisms in genes involved in the dopaminergic signaling pathway and substance abuse, as well as to assess the prevalence of human anelloviruses. Individuals hospitalized for substance abuse (n = 15) and healthy subjects (n = 15) were recruited for the study. Blood samples were collected and used for isolating DNA and genotyping two polymorphisms in dopamine signaling genes (i.e., DRD2 TaqI A, DAT1 VNTR) using PCR-RFLP. Anelloviral DNA was detected using hemi-nested PCR. The distribution of polymorphisms did not differ from Hardy-Weinberg equilibrium in the investigated groups. A slightly higher frequency of the A1 allele of DRD2 TaqI A polymorphism was found in the substance abuse group, consistent with literature. The DAT1 VNTR 12R allele associated with lower expression of DAT1 and slower dopamine reuptake at the synapse level, appears to be protective against this type of behavior. Additionally, anelloviral DNA was present in all study participants, in line with previous reports. DAT1 VNTR genotypes might be associated with substance abuse. However, replication of results in larger groups, study of other genes, environmental factors, and their interactions are important to obtain a broader understanding of this behavior.

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Phylogenetic analysis of torque teno virus in Romania: possible evidence of distinct geographical distribution

Cited by 3 publications

References 49 publications

The mysterious anelloviruses: investigating its role in human diseases

The mysterious anelloviruses: investigating its role in human diseases

Detection and Genomic Characterization of Torque Teno Virus in Pneumoconiosis Patients in China

Investigating the Role of Dopamine Signaling Gene Polymorphisms and Prevalence of Human Anelloviruses Infection in Substance Abuse

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