“…Previous research on Lendenfeldia sponges revealed a rich diversity of secondary metabolites, with sesterterpenoids being particularly prominent [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. These sesterterpenoids exhibit a broad spectrum of biological activities, including cytotoxicity [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ], anti-inflammatory properties [ 5 , 7 , 18 , 32 , 33 , 34 , 35 , 36 ], anti-HIV effects [ 3 , 37 ], anti-microbial [ 15 , 16 , 22 , 38 , 39 , 40 , 41 ] and anti-neurofibroma activity [ 42 ]. Anti-n...…”