Phyllodes tumors of the breast: Analysis of 35 cases from a single institution

Demian, Gerges Attia; Fayaz, Salah; Eissa, Heba El-Sayed; Nazmy, Nashwa; Samir, Suzanne; George, Thomas J.; El-Sherify, Mustafa; Abuzalouf, Sadeq

doi:10.1016/j.jnci.2016.06.004

Cited by 30 publications

(26 citation statements)

References 24 publications

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“…After a thorough review of abstracts and exclusion of duplicated references, 46 studies were treated as candidates. Further examination of the manuscripts led to the inclusion of 17 radiotherapy studies for meta-analysis [3,9,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The literature search flow chart is displayed in Fig.…”

Section: Search Resultsmentioning

confidence: 99%

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Xue

Chen

Zeng³

et al. 2019

BMC Cancer

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Background: As the efficacy of radiotherapy and chemotherapy for treatment of phyllodes tumors (PTs) remains unclear, this study aimed to review all available data and evaluate the roles of radiotherapy and chemotherapy in PT treatment. Methods: We performed a comprehensive search of databases, including PubMed, Web of Science and the Cochrane Library. The outcomes of interest included the local recurrence (LR) rate, metastasis rate, disease-free survival rate and overall survival rate. Results: Seventeen studies enrolling 696 patients were included in this random effect meta-analysis. Subgroup analysis and meta-regression were also conducted to determine study heterogeneity. A pooled local recurrence rate of 8% (95% CI: 1-22%) was observed with a statistical heterogeneity of I 2 = 86.6% (p < 0.01) for radiotherapy. This was lower than the recurrence rate of 12% for simple surgical treatment (95% CI: 7-18%). Meta-regression analysis found that surgical margin status was the main source of heterogeneity (p = 0.04). The metastasis rate of 4% (95% CI: 0-11%) for patients receiving radiotherapy without significant heterogeneity was also lower than the rate for the simple surgery group (8, 95% CI: 3-15%). The available data for chemotherapy were too limited to support meta-analysis. Accordingly, we offer a pure review of these data. Conclusion: Our findings suggest that radiotherapy is effective in achieving local disease control and preventing metastasis.

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Section: Search Resultsmentioning

confidence: 99%

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Xue

Chen

Zeng³

et al. 2019

BMC Cancer

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“…8,18 They are more commonly found in upper outer quadrant, whereas huge lesions tend to involve more than one quadrant. 19 The side of tumour (left versus right breast) is not significantly different between benign, borderline and malignant tumours. 9 This is similar to the occurrence of infiltrative breast carcinoma.…”

Section: Clinical Featuresmentioning

confidence: 91%

Approaches to phyllodes tumour of the breast: a review article

et al. 2017

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Phyllodes tumours are rare entities of fibroepithelial diseases. The exact pathogenesis and their relationship with fibroadenomas are oblivious. Women aged between 35 to 55 years are commonly affected, even younger in Asian population. Triple assessment should be applied as a guide to management in any breast pathology. Clinical appearances are typically diagnostic for phyllodes tumours. Even though sometimes inconclusive, mammography and ultrasonography are the main imaging modalities. Although the role of cytology is debatable, presence of both epithelial and stromal elements supports the diagnosis especially in malignant type. Core biopsy is rather favored in view of higher accuracy for the diagnosis. Accurate preoperative assessment and histologic diagnosis allow correct surgical intervention and subsequent avoidance of reoperation. Surgical management can be either wide excision with more than 1 cm margins or mastectomy without axillary surgery. Local recurrence has been associated with inadequate excision of the pseudopod. Adjuvant radiotherapy is recommended for positive surgical margin and for local control of borderline and malignant phyllodes tumors. The role of chemotherapy and endocrine therapy has not been fully studied.

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“…Surgery is the main modality of treatment and usually involves wide local excision, sometimes necessitating mastectomy and resection of related structures and requiring either delayed or immediate reconstruction. Several recent reports have noted that it is locally destructive but patients have a good prognosis if a wide local excision is performed, because nodal and distant metastasis is rare 6–9. For our patient, the phyllodes tumour resection necessitated reconstruction of the anterior chest wall.…”

Section: Discussionmentioning

confidence: 79%

Combined bipedicled latissimus dorsi and groin flap for anterior chest wall reconstruction

Boonipat

Manrique³

et al. 2019

BMJ Case Rep

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We provide a case report of reconstruction of a massive chest wall defect after recurrent phyllodes tumour resections. The reconstruction used a bipedicled groin and latissimus dorsi flap, with composite rib autologous reconstruction. The patient successfully recovered from the operation. Our case illustrates the applicability of this flap in the armamentarium of anterior chest wall reconstructive options.

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Phyllodes tumors of the breast: Analysis of 35 cases from a single institution

Cited by 30 publications

References 24 publications

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Approaches to phyllodes tumour of the breast: a review article

Combined bipedicled latissimus dorsi and groin flap for anterior chest wall reconstruction

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