Phyllodes tumor of the breast with nipple discharge

Abstract

Rationale:Phyllodes tumors (PTs) of the breast are rare biphasic fibroepithelial neoplasms which usually present with unilateral palpable breast lumps. Here we reported a case of borderline PTs with multifocal intraductal lesions whose primary clinical manifestation was nipple discharge.Patient concerns:A rare case of PT with nipple discharge in a 26-year-old young lady accepted a wide local excision on her left breast, and the pathological examination turned out to be a malignant phyllodes tumor. After a 12-month follow-up, no local or distant recurrence was observed.Diagnosis:Borderline PTs with multifocal intraductal lesionsInterventions:The patient received wide local excision with clear margin. After the operation, the patient is undergoing surveillance through ultrasonography and physical examination every 3 months.Outcomes:After a follow-up of 12 months, no local or distant recurrence was observed.Lessons:The lesions of the PTs are often manifested with unilateral, palpable masses in the breast. There are very few case reports of PTs manifested with nipple discharge in the literature. We should improve the understanding of the multiple clinical manifestations of PTs.

Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature

“…Nipple retraction, ulceration, chest wall fixation, and bilateral diseases are rare (33%), but have been described for phyllodes tumors. The most frequent location is in the right breast, being multicentric in a third of cases; 35% are in the upper external quadrant, 15% in the upper internal quadrant, 10–25% in the lower external quadrant, and fewer than 10% in the lower internal quadrant [3, 10, 16, 44, 51, 52]. Although palpable axillary lymphadenopathy can be identified in up to 20% of patients, most cases are reactive; metastatic involvement of lymph nodes with phyllodes tumor is rare [51-53].…”

“…Microscopically, the characteristic leaf-like architecture consists of elongated cleft-like spaces that contain papillary projections of epithelial-lined stroma with varying degrees of hyperplasia and atypia. The stromal elements are a key component in differentiating phyllodes tumors from fibroadenomas and in differentiating a benign tumor from a malignant one [16, 47, 54, 58]. Phyllodes tumor is classified as benign, borderline, or malignant according to the WHO classification of 2012 [59] (Table 1).…”

Case Report: Mitral valve obstruction by metastatic malignant phyllodes tumor

“…Phyllodes tumors (PTs) represent a rare category of breast neoplasm, with a prevalence accounting for <1% of all breast tumors. 1 PTs predominantly occur in women aged 35-50 years, 2 and they range from benign to malignant forms according to the histological features. 3 Malignant PTs account for 16% to 30% of all PTs and they have an inherent recurrence and/or metastasis potential.…”

Malignant Phyllodes Tumor by the Example of a Clinical Case

“…Природа их не совсем понятна, но эндотелин1, стимулятор роста фибро бластов молочной железы, может быть сопутству ющим фактором [4]. Листовидная опухоль диагно стируется у пациентов разного возраста от 10 до 70 лет, но пик заболеваемости приходится на лиц в возрасте от 40 до 50 лет [5].…”